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J Dermatolog Treat. 2025 Dec;36(1):2474507. doi: 10.1080/09546634.2025.2474507. Epub 2025 Mar 6. ABSTRACT BACKGROUND: Emerging research suggests that Janus kinase-signal transducer and activator of transcription (JAK-STAT) inhibitors may be associated with a higher risk of serious infection for patients with rheumatoid arthritis. However, there is no consensus on whether JAK inhibitors increase the risk of serious infection in patients with Immune-mediated inflammatory skin diseases (IMISDs). OB

BMC Womens Health. 2025 Mar 6;25(1):101. doi: 10.1186/s12905-025-03625-2. ABSTRACT BACKGROUND: Skin diseases are a category of chronic conditions that often impact patients' appearance, potentially leading to psychological issues, including sexual dysfunction. The present study is an attempt to determine the global prevalence of female sexual dysfunction (FSD) in women with skin diseases. METHODS: For this systematic review and meta-analysis, databases including PubMed, Web of Science, Scopus, S

Gut Microbes. 2025 Dec;17(1):2473524. doi: 10.1080/19490976.2025.2473524. Epub 2025 Mar 6. ABSTRACT This review explores the emerging term "gut-skin axis" (GSA), describing the bidirectional signaling that occurs between the skin and the gastrointestinal tract under both homeostatic and disease conditions. Central to GSA communication are the gut and skin microbiota, the microbial communities that colonize these barrier surfaces. By influencing diverse host pathways, including innate immune, vit

Dermatol Ther (Heidelb). 2025 Mar 6. doi: 10.1007/s13555-025-01370-w. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disease affecting over 60 million people worldwide, often linked to comorbidities such as psoriatic arthritis and cardiovascular disease. Beyond physical symptoms, psoriasis can significantly impact major life-changing decisions (MLCDs), leading to long-term consequences and missed opportunities. This study focused on assessing MLCDs and the

Adv Ther. 2025 Mar 6. doi: 10.1007/s12325-025-03138-2. Online ahead of print. ABSTRACT INTRODUCTION: Biosimilars allow more patients access to affordable treatment options and help reduce the financial burden on healthcare systems. This multicentre trial compared the efficacy, safety, and immunogenicity of the approved biosimilar ustekinumab FYB202 with reference ustekinumab. METHODS: Eligible patients were ≥ 18 years old with stable moderate-to-severe plaque psoriasis for ≥ 6 months and inadequ

Dermatol Ther (Heidelb). 2025 Mar 6. doi: 10.1007/s13555-024-01317-7. Online ahead of print. NO ABSTRACT PMID:40048065 | DOI:10.1007/s13555-024-01317-7 Den ganzen Artikel lesen

Curr Nutr Rep. 2025 Mar 6;14(1):42. doi: 10.1007/s13668-025-00632-5. ABSTRACT PURPOSE OF REVIEW: In this narrative review, we provide an overview of how adherence to a Mediterranean dietary pattern can complement traditional treatment strategies for psoriasis, acne, and hidradenitis suppurativa. We emphasize the importance of an integrated approach, with dietary interventions as a key component of holistic patient care. RECENT FINDINGS: Psoriasis, acne, and hidradenitis suppurativa are immune-me

Dermatol Reports. 2025 Feb 6;17(1). doi: 10.4081/dr.2024.9999. Epub 2024 Aug 9. ABSTRACT Psoriasis is an inflammatory chronic disease of the skin, typically located on the extensor surfaces of the body and the trunk. Patients with psoriasis can often present multiple characteristics, such as lesions located in difficult-to-treat (DTT) areas or high severity of the disease, which can negatively affect their quality of life. There is a lack of consensus in identifying the best therapy for these co

Dermatol Reports. 2025 Mar 5. doi: 10.4081/dr.2025.10239. Online ahead of print. ABSTRACT Infantile hemangiomas are the most common soft-tissue tumors in children, with propranolol, a non-cardioselective β-blocker, considered the first-line treatment for complicated cases. β-blockers have been reported to be the most common causative agents for drug-induced psoriasis in adults. In the pediatric population, only one previous case exists. We report the case of a 12-month-old girl who developed a p

J Insur Med. 2025 Jul 1;52(1):3-5. doi: 10.17849/insm-52-1-3-5.1. ABSTRACT OBJECTIVE.—: To analyze a published study on all-cause mortality between psoriatic arthritis and matched population comparator-subjects to derive comparative mortality statistics applicable to life insurance underwriting. METHOD.—: The pixel method was employed for extracting cumulative survivals. It was chosen for its capability to extract data from published graphs despite potential precision and reliability limitations

Ital J Dermatol Venerol. 2024 Dec;159(6):684-685. doi: 10.23736/S2784-8671.24.08051-4. NO ABSTRACT PMID:39898382 | DOI:10.23736/S2784-8671.24.08051-4 Den ganzen Artikel lesen

Ital J Dermatol Venerol. 2024 Dec;159(6):663-675. doi: 10.23736/S2784-8671.24.08083-6. ABSTRACT The introduction of systemic biologic therapies marked a significant advancement in the treatment of moderate to severe psoriasis. However, the high cost associated with these treatments has considerably restricted their widespread utilization. The expiration of biologic patents has allowed the development of biosimilars - medications that are highly similar to approved biologics. Biosimilars hold the

Ital J Dermatol Venerol. 2024 Dec;159(6):599-606. doi: 10.23736/S2784-8671.24.07914-3. ABSTRACT BACKGROUND: Biologic drugs have revolutionized the treatment of psoriasis and other chronic inflammatory diseases. In recent years, numerous biosimilar molecules that target cytokines such as TNF-alpha or its receptors have been developed. The approval of biosimilars has made it possible to reduce the costs of biologic drugs, thereby increasing access to these therapies for more patients and enhancing

Int J Med Sci. 2025 Jan 1;22(3):558-564. doi: 10.7150/ijms.102434. eCollection 2025. ABSTRACT Background: Recent studies suggest a potential link between HS and renal dysfunction. Our objective is to assess the correlation between hidradenitis suppurativa (HS) and renal consequences, specifically focusing on acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). Methods: This study was performed based on retrospective cohort design. Electronic medical record

JAAD Int. 2024 Nov 14;19:12-20. doi: 10.1016/j.jdin.2024.09.015. eCollection 2025 Apr. ABSTRACT BACKGROUND: There is limited evidence on treating psoriasis patients with skin of color (SOC), contributing to disparities in accessing appropriate care for these patients. OBJECTIVES: This study aimed to develop consensus statements defining SOC terminology and addressing needs to optimize the clinical management of psoriasis in patients with SOC. METHODS: Using the modified Delphi methodology 16 Can

SAGE Open Med Case Rep. 2025 Jan 31;13:2050313X251317763. doi: 10.1177/2050313X251317763. eCollection 2025. ABSTRACT Palmoplantar plaque psoriasis is more resistant to therapy compared to other phenotypes of psoriasis. To our knowledge, there are no reports of the efficacy of Janus kinase (JAK) inhibitors for palmoplantar plaque psoriasis. Two adult females presented with more than 6-year histories of severe palmoplantar plaque psoriasis. The first patient had failed topical therapies, photother

Ther Adv Musculoskelet Dis. 2025 Jan 31;17:1759720X251315138. doi: 10.1177/1759720X251315138. eCollection 2025. ABSTRACT BACKGROUND: Randomized clinical trials have demonstrated the efficacy of secukinumab (SECU) in reducing disease activity in psoriatic arthritis (PsA), while real-world studies prove a broader perspective on SECU's usefulness in everyday clinical practice. OBJECTIVES: To assess the effectiveness of SECU by evaluating drug survival and identifying potential predictors of clinica

Cureus. 2025 Jan 3;17(1):e76869. doi: 10.7759/cureus.76869. eCollection 2025 Jan. ABSTRACT While topical steroids are an invaluable tool used for the treatment of pruritic rashes, they can also complicate attempts at a definitive diagnosis. The temporal association between steroid use and biopsy must be taken into account when investigating the underlying etiology of such rashes. In patients with a history of dermatologic disease with the onset of a new rash, management should include a biopsy,

Indian J Dermatol. 2025 Jan-Feb;70(1):42-46. doi: 10.4103/ijd.ijd_719_24. Epub 2024 Dec 30. ABSTRACT Behçet's disease is a chronic inflammatory condition that affects multiple organs and systems. It is characterized by recurrent oral and genital ulcers. A previous study reported that the IL-17A inhibitor secukinumab can improve the skin and mucosal manifestations in patients with refractory Behçet's disease. Additionally, secukinumab has been shown to effectively improve neurological symptoms wh

J Dermatol. 2025 Feb 3. doi: 10.1111/1346-8138.17645. Online ahead of print. ABSTRACT The association between psoriasis and streptococcal infection has been widely explored in both children and adults. However, the exact impact of Streptococcus pharyngeal infection on the course of psoriasis is not fully comprehended. This study explored the impact of Streptococcus pharyngeal infection on psoriasis and investigated the effectiveness of systemic antibiotic therapy in conjunction with standard top

Arch Dermatol Res. 2025 Jan 18;317(1):291. doi: 10.1007/s00403-024-03786-4. ABSTRACT This study aims to explore the measurement agreement between direct and indirect health utility measures in four chronic dermatological conditions (atopic dermatitis, hidradenitis suppurativa, pemphigus, psoriasis). Outpatients survey data collected between 2015 and 2021 were analysed. Health-related quality of life (HRQoL) outcome measures included time trade-off (TTO), EQ-5D-5L and Dermatology Life Quality Ind

Arch Dermatol Res. 2025 Jan 18;317(1):282. doi: 10.1007/s00403-024-03676-9. ABSTRACT One of the most frequently impacted locations by psoriasis is the scalp. It is seen in about 80% of psoriasis cases worldwide, and its treatment is challenging. To compare the efficacy and safety of excimer light versus topical methotrexate (MTX) 1% hydrogel in treatment of scalp psoriasis. This randomized prospective intra-patient comparative study was carried out on 30 patients with scalp psoriasis. Lesions we

Arch Dermatol Res. 2025 Jan 18;317(1):286. doi: 10.1007/s00403-025-03818-7. ABSTRACT Atherosclerosis, in which chronic inflammation is also effective in it's pathogenesis, is an important cause of morbidity and mortality in psoriasis patients. Early diagnosis and management of atherosclerosis is important. Measurement of carotid intima media thickness is a method used to determine subclinical atherosclerosis. Our aim in this study is to evaluate subclinical atherosclerosis in psoriasis patients

FEBS Open Bio. 2025 Jan 17. doi: 10.1002/2211-5463.13969. Online ahead of print. ABSTRACT Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory medication used to treat multiple sclerosis (MS) and psoriasis. Its skin sensitization property precludes its topical use, which is unfortunate for the treatment of psoriasis. Isosorbide di-(methyl fumarate) (IDMF), a novel derivative of DMF, was synthesized to circumvent this adverse reaction and unlock the potential of topical delivery,

Prim Care Companion CNS Disord. 2025 Jan 9;27(1):24cr03803. doi: 10.4088/PCC.24cr03803. NO ABSTRACT PMID:39823455 | DOI:10.4088/PCC.24cr03803 Den ganzen Artikel lesen