Aus Pubmed

Pharmaceutics. 2024 Mar 26;16(4):458. doi: 10.3390/pharmaceutics16040458. ABSTRACT The aim of this review is to provide a summary of the botany, phytochemistry and dermatological effects of Punica granatum (PG), with special emphasis on therapeutic mechanisms in various skin conditions. PG peel contains the highest levels of chemical compounds. Due to the high abundance of polyphenolic compounds, including phenolic acids, anthocyanins and flavonoids, exhibiting strong antioxidant properties, PG

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17470. Online ahead of print. NO ABSTRACT PMID:39349977 | DOI:10.1111/1346-8138.17470 Den ganzen Artikel lesen

Clin Cosmet Investig Dermatol. 2024 Sep 23;17:2111-2115. doi: 10.2147/CCID.S482555. eCollection 2024. ABSTRACT The patient, a 77-year-old Asian male presented with herpes zoster in the left lumbar and abdominal regions 9 weeks before presentation. The infection dried up after 2 weeks but was followed by an erythematous scaly rash in the same region with left-sided abdominal elevation. Pathological examination revealed continuous parakeratosis and Munro microabscesses. Abdominal computer tomograp

JAAD Case Rep. 2024 Sep 12;53:90-92. doi: 10.1016/j.jdcr.2024.08.027. eCollection 2024 Nov. NO ABSTRACT PMID:39823051 | PMC:PMC11736156 | DOI:10.1016/j.jdcr.2024.08.027 Den ganzen Artikel lesen

Cureus. 2024 May 9;16(5):e60008. doi: 10.7759/cureus.60008. eCollection 2024 May. ABSTRACT Methotrexate is an anti-inflammatory and immunomodulatory drug, widely used for moderate to severe psoriasis and other rheumatological conditions such as rheumatoid arthritis, besides some types of malignancies. Side effects are more prevalent in high acute doses but can also be seen in low-dose chronic use, especially in cases of drug-dosing errors. Possible symptoms of toxicity include gastrointestinal,

Arch Dermatol Res. 2024 Jun 7;316(7):340. doi: 10.1007/s00403-024-03075-0. ABSTRACT Psoriasis (PsO) is a chronic inflammatory skin condition, often accompanied by psoriatic arthritis (PsA) and linked to various comorbidities and increased mortality rates. This study aimed to explore the relationship between PsO and accelerated biological aging, specifically focusing on epigenetic DNA methylation clocks. Using a matched case-control design, 20 PsO cases were selected along with age, race, and sex

BMC Cancer. 2024 Apr 12;24(1):458. doi: 10.1186/s12885-024-12188-8. ABSTRACT BACKGROUND: The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to predict prognosis for acute myeloid leukemia (AML). METHODS: 952 patients with pathologically-confirmed AML were retrospectively enrolled between 2010 and 2020. CT-derived features (including body composit

Cureus. 2024 May 8;16(5):e59878. doi: 10.7759/cureus.59878. eCollection 2024 May. ABSTRACT Background Psoriasis is a papulosquamous disease with variable morphology, distribution, severity, and course. Chronic plaque psoriasis, or psoriasis vulgaris, is the most common form of psoriasis. Present available preparations for mild to moderate chronic plaque psoriasis for topical use are local corticosteroids, coal tar, dithranol, tazarotene, calcipotriol, tapinarof, and calcineurin inhibitors. Howev

Diagnostics (Basel). 2024 Dec 28;15(1):55. doi: 10.3390/diagnostics15010055. ABSTRACT Background: Psoriasis is a chronic, immune-mediated skin disease characterized by lifelong persistence and fluctuating symptoms. The clinical similarities among its subtypes and the diversity of symptoms present challenges in diagnosis. Early diagnosis plays a vital role in preventing the spread of lesions and improving patients' quality of life. Methods: This study proposes a hybrid model combining multiple tr

Int J Mol Sci. 2025 Jan 4;26(1):394. doi: 10.3390/ijms26010394. ABSTRACT Inflammatory skin diseases comprise a group of skin conditions characterized by damage to skin function due to overactive immune responses. These disorders not only impair the barrier function of the skin but also deteriorate the quality of life and increase the risk of psychiatric issues. Here, a low-modulus phosphatidylserine-exposing microvesicle (deformed PSV, D-PSV) was produced, characterized, and evaluated for its po

Autoimmun Rev. 2024 Oct 21:103671. doi: 10.1016/j.autrev.2024.103671. Online ahead of print. ABSTRACT AIM: To produce a unique metric 'autoimmune disease (ADs)' based on various single autoimmune disorder and estimate its case number and age-standardized rate of incidence for each stage in life cycle of women from 1990 to 2019, and to further explore their temporal trends at global, regional, and national levels. METHODS: A comprehensive classification for life cycle of women was proposed. The e

J Dermatol. 2025 Jan 11. doi: 10.1111/1346-8138.17623. Online ahead of print. NO ABSTRACT PMID:39797588 | DOI:10.1111/1346-8138.17623 Den ganzen Artikel lesen

Br J Health Psychol. 2025 Feb;30(1):e12778. doi: 10.1111/bjhp.12778. ABSTRACT OBJECTIVES: Skin conditions carry a substantial psychological burden but support for patients is limited. Digital technology could support patient self-management; we found preliminary evidence for the effectiveness and acceptability of digital psychological interventions for adults living with skin conditions. We have, therefore, developed a complex digital intervention called MiDerm with patients. This qualitative st

Adv Ther. 2025 Mar 6. doi: 10.1007/s12325-025-03138-2. Online ahead of print. ABSTRACT INTRODUCTION: Biosimilars allow more patients access to affordable treatment options and help reduce the financial burden on healthcare systems. This multicentre trial compared the efficacy, safety, and immunogenicity of the approved biosimilar ustekinumab FYB202 with reference ustekinumab. METHODS: Eligible patients were ≥ 18 years old with stable moderate-to-severe plaque psoriasis for ≥ 6 months and inadequ

Cureus. 2024 Dec 4;16(12):e75105. doi: 10.7759/cureus.75105. eCollection 2024 Dec. ABSTRACT Erythrodermic psoriasis (EP) is a rare and challenging-to-diagnose severe form of psoriasis. Its presentation can have similarities with other inflammatory skin conditions, complicating subsequent management. We present a case of a 76-year-old woman with EP who presented with fever, tachycardia, leg swelling with pain and redness, and reduced consciousness. Her imaging revealed characteristic features of

Sci Rep. 2025 Jan 17;15(1):2346. doi: 10.1038/s41598-025-86976-y. ABSTRACT Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, the strict inclusion and exclusion criteria may not fully reflect its safety profile in real-world settings. As its use becomes more widespread in clinical practice, understanding its safety in

Arch Dermatol Res. 2024 Jun 7;316(7):347. doi: 10.1007/s00403-024-03147-1. NO ABSTRACT PMID:38849678 | DOI:10.1007/s00403-024-03147-1 Den ganzen Artikel lesen

Best Pract Res Clin Rheumatol. 2024 Sep 1:101982. doi: 10.1016/j.berh.2024.101982. Online ahead of print. ABSTRACT Spondyloarthropathies (SpA), including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have been shown to have a substantial genetic predisposition based on heritability estimates derived from family studies and genome-wide association studies (GWAS). GWAS have uncovered numerous genetic loci associated with susceptibility to SpA, with significant associations to human le

World Allergy Organ J. 2024 Dec 19;18(1):101014. doi: 10.1016/j.waojou.2024.101014. eCollection 2025 Jan. ABSTRACT BACKGROUND: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. METHODS: This study conducted a phenome-wide association study (PheWAS) using known AR risk

Phenomics. 2023 Aug 21;4(1):46-50. doi: 10.1007/s43657-023-00110-4. eCollection 2024 Feb. ABSTRACT Commonly affected in early-life population, the impact of allergic phenotypes on mid- or late-life health is less discussed. This study is to explore the association of allergic phenotypes including atopic dermatitis (AD), asthma, eosinophils count (EC), and sarcopenia. We conducted observational studies and mendelian randomization (MR) analysis based on UK Biobank (UKB), the China Health and Retir

Arch Dermatol Res. 2024 Dec 14;317(1):115. doi: 10.1007/s00403-024-03550-8. ABSTRACT Psoriasis is a chronic, relapsing, inflammatory skin disease that is caused by the immune system. Amygdalin possesses immune-modulating and anti-inflammatory effects. To explore the possible effects of amygdalin on psoriasis and its pathogenesis of action, we examined the effects of amygdalin on imiquimod-induced psoriasis, tape-stripping-induced skin barrier disruption, and investigated the potential mechanism

Cureus. 2024 Sep 3;16(9):e68556. doi: 10.7759/cureus.68556. eCollection 2024 Sep. ABSTRACT Psoriasis is a chronic inflammatory skin condition characterized by well-demarcated, erythematous plaques. Certain medications, including Angiotensin-Converting Enzyme (ACE) inhibitors, have been implicated as potential triggers for psoriasis flare-ups. We report the case of a 48-year-old Indian male with a history of well-controlled plaque psoriasis who experienced severe flare-ups after initiating ACE in

Macromol Rapid Commun. 2024 Apr 9:e2400136. doi: 10.1002/marc.202400136. Online ahead of print. ABSTRACT In the work, we designed a natural medicine baicalin for the treatment of psoriasis with the aid of hyaluronic acid (HA)-based MNs patches. In order to improve the solubility of baicalin and increase its residence time in infected part, which was made into nanoparticles by complexation with humic acid and Eu2+. The baicalin nanoparticles loaded-MNs exhibited satisfactory rigidity, minimum inj

Arch Dermatol Res. 2024 Jun 8;316(7):363. doi: 10.1007/s00403-024-03051-8. ABSTRACT Streptococcal infections may contribute to psoriasis development, and antistreptococcal treatments are considered potential therapies, but their effectiveness remains uncertain due to limited systematic evidence. Our objective was to analyze antistreptococcal therapies' effectiveness in improving psoriasis. We conducted a systematic review following PRISMA guidelines, evaluating antistreptococcal treatment effica

J Eur Acad Dermatol Venereol. 2024 Oct 24. doi: 10.1111/jdv.20400. Online ahead of print. NO ABSTRACT PMID:39445679 | DOI:10.1111/jdv.20400 Den ganzen Artikel lesen