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Antioxidants (Basel). 2024 Mar 30;13(4):425. doi: 10.3390/antiox13040425. ABSTRACT Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also k

J Cutan Med Surg. 2024 Jun 7:12034754241260023. doi: 10.1177/12034754241260023. Online ahead of print. ABSTRACT There has been a call to action to enhance representation of non-white individuals in dermatology clinical trials. Investigations in differential response to treatment across populations are limited, particularly in conditions of commonality, impact, distinct presentation, and diagnosis in non-white participants, such as atopic dermatitis and psoriasis. This systematic review summarize

Dermatology. 2024 Apr 8. doi: 10.1159/000536366. Online ahead of print. ABSTRACT BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and dis

J Am Acad Dermatol. 2024 Apr 6:S0190-9622(24)00568-1. doi: 10.1016/j.jaad.2024.03.041. Online ahead of print. ABSTRACT BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferas

Arch Dermatol Res. 2024 Jun 7;316(7):347. doi: 10.1007/s00403-024-03147-1. NO ABSTRACT PMID:38849678 | DOI:10.1007/s00403-024-03147-1 Den ganzen Artikel lesen

Rheumatol Adv Pract. 2024 Apr 10;8(2):rkae052. doi: 10.1093/rap/rkae052. eCollection 2024. NO ABSTRACT PMID:38698954 | PMC:PMC11065474 | DOI:10.1093/rap/rkae052 Den ganzen Artikel lesen

Int J Surg. 2024 May 3. doi: 10.1097/JS9.0000000000001514. Online ahead of print. ABSTRACT BACKGROUND: Glucagon-like peptide-1 receptor (GLP1R) agonists have been approved by Food and Drug Administration for management of obesity. However, the causal relationship of GLP1R agonists (GLP1RA) with cancers still unclear. METHODS: The available cis-eQTLs for drugs target genes (GLP1R) were used as proxies for exposure to GLP1RA. Mendelian randomizations (MR) were performed to reveal the association o

J Rheumatol. 2024 Jun 7:jrheum.2024-0330. doi: 10.3899/jrheum.2024-0330. Online ahead of print. ABSTRACT The 78th Annual Meeting of the Canadian Rheumatology Association was held at the RBC Convention Centre in Winnipeg, Manitoba, Canada, and virtually on February 28-March 2, 2024. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2024 Award Winners: Distinguished Rheumatologist, John M. Esdaile; Dis

Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831. ABSTRACT Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histo

J Clin Aesthet Dermatol. 2024 May;17(5 Suppl 2):S7-S10. NO ABSTRACT PMID:38726208 | PMC:PMC11078528 Den ganzen Artikel lesen

Front Immunol. 2024 Mar 26;15:1374763. doi: 10.3389/fimmu.2024.1374763. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated disorder influenced by environmental factors on a genetic basis. Despite advancements, challenges persist, including the diminishing efficacy of biologics and small-molecule targeted agents, alongside managing recurrence and psoriasis-related comorbidities. Unraveling the underlying pathogenesis and identifying valuable biomarkers remain pivotal for diagn

Cureus. 2024 May 10;16(5):e60051. doi: 10.7759/cureus.60051. eCollection 2024 May. ABSTRACT Psoriasis is a chronic dermatologic condition that oftentimes requires extensive trial and error with various topical and systemic therapies until improvement is achieved. Interleukin-17 inhibitors (IL-17i), such as secukinumab, have been utilized in the treatment of psoriasis due to their mechanism of action. As with all medications, IL-17 inhibitors possess adverse effects, the most common being infecti

Front Oncol. 2024 Mar 28;14:1331419. doi: 10.3389/fonc.2024.1331419. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fonc.2023.1185389.]. PMID:38606107 | PMC:PMC11008677 | DOI:10.3389/fonc.2024.1331419 Den ganzen Artikel lesen

J Clin Med. 2024 Mar 27;13(7):1940. doi: 10.3390/jcm13071940. ABSTRACT Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evid

Ital J Dermatol Venerol. 2024 May 10. doi: 10.23736/S2784-8671.24.07664-3. Online ahead of print. ABSTRACT SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of the present guideline on the systemic treatment of chronic plaque psoriasis. With the permission of EuroGuiDerm, SIDeMaST adapted the guideline to the Italian healthcare context to supply a reliable and affordable tool to Italian physicians who t

Front Immunol. 2024 May 23;15:1410540. doi: 10.3389/fimmu.2024.1410540. eCollection 2024. ABSTRACT Psoriasis is a common, life-long skin disease with a significant negative health and societal impact. Data on rates of disease control and treatment strategies are lacking in Central and Eastern European countries. We aimed to describe the real-world disease severity, control, and treatment strategies for psoriasis in patients from Central and Eastern European countries. CRYSTAL (EUPAS36459) was a

Arch Dermatol Res. 2024 May 17;316(5):176. doi: 10.1007/s00403-024-02886-5. ABSTRACT Psoriasis is a chronic immune mediated inflammatory skin disease with systemic manifestations. It has been reported that caloric restriction could improve severity of psoriasis patients. However, the mechanism of intermittent fasting effects on psoriasis has not been investigated. Caloric restriction is known to reduce the number of circulating inflammatory monocytes in a CCL2-dependent manner. However, it is st

Int J Mol Sci. 2024 Mar 23;25(7):3617. doi: 10.3390/ijms25073617. ABSTRACT Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin

Arch Dermatol Res. 2024 May 18;316(5):181. doi: 10.1007/s00403-024-02978-2. ABSTRACT Background An increasing body of observational studies has indicated a potential link between allergic diseases, namely atopic dermatitis (AD), allergic rhinitis (AR), allergic asthma (AA), and psoriasis (PSO) as well as psoriatic arthritis (PSA). However, the presence and causal direction of this association remain uncertain. Methods We conducted two-sample Mendelian randomization (TSMR) analyses utilizing summ

Int J Mol Sci. 2024 Mar 29;25(7):3823. doi: 10.3390/ijms25073823. ABSTRACT Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace elements are zinc, copper, and iron. A deficiency or excess of trace elements can be associated with an increased risk of skin diseases, so increasing their supplementation or limiting intake can be helpful in dermatological treatment. In addition, determinati

Mil Med. 2024 Apr 11:usae139. doi: 10.1093/milmed/usae139. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis and atopic dermatitis are chronic, immune-mediated skin disorders that are disqualifying for entrance into the military. Both conditions can cause difficulty wearing body armor and other protective equipment when poorly controlled, limiting a service member's ability to train and deploy worldwide. In addition, these conditions may be exacerbated by military service because of increa

J Clin Med. 2024 Apr 12;13(8):2250. doi: 10.3390/jcm13082250. ABSTRACT Background/Objectives: Treating psoriasis patients requires the consideration of potential underlying complications like latent viral infections and chronic kidney disease, which may influence therapy selection. Case presentation: A patient with end-stage kidney disease (ESKD) undergoing hemodialysis (HD) was successfully treated with bimekizumab, an IgG1 humanized monoclonal antibody inhibiting interleukin (IL)-17A and IL-17

Curr Med Res Opin. 2024 Apr 10:1-13. doi: 10.1080/03007995.2024.2340720. Online ahead of print. ABSTRACT OBJECTIVE: Effective health communication is critical for understanding and acting on health information. This cross-sectional study explored participants' understanding of their health condition, their preferences for receiving health communications, and their interest in receiving clinical trial results across several therapeutic areas. METHODS: The study recruited participants via social m

Macromol Rapid Commun. 2024 Apr 9:e2400136. doi: 10.1002/marc.202400136. Online ahead of print. ABSTRACT In the work, we designed a natural medicine baicalin for the treatment of psoriasis with the aid of hyaluronic acid (HA)-based MNs patches. In order to improve the solubility of baicalin and increase its residence time in infected part, which was made into nanoparticles by complexation with humic acid and Eu2+. The baicalin nanoparticles loaded-MNs exhibited satisfactory rigidity, minimum inj

Arch Dermatol Res. 2024 Jun 8;316(7):369. doi: 10.1007/s00403-024-03074-1. NO ABSTRACT PMID:38850288 | DOI:10.1007/s00403-024-03074-1 Den ganzen Artikel lesen