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J Clin Aesthet Dermatol. 2024 May;17(5 Suppl 2):S7-S10. NO ABSTRACT PMID:38726208 | PMC:PMC11078528 Den ganzen Artikel lesen

J Pediatr. 2024 Dec 12:114436. doi: 10.1016/j.jpeds.2024.114436. Online ahead of print. ABSTRACT OBJECTIVES: To examine pediatrician diagnostic skill development of dermatology image-based cases via a web-based tool and to determine case-level variables that were associated with diagnostic error. STUDY DESIGN: This was a multi-center, prospective, cross-sectional study. A convenience sample of pediatric trainees and attendings were eligible for participation. Using a web-based tool, physicians p

J Am Acad Dermatol. 2024 Apr 25:S0190-9622(24)00654-6. doi: 10.1016/j.jaad.2024.03.048. Online ahead of print. NO ABSTRACT PMID:38677338 | DOI:10.1016/j.jaad.2024.03.048 Den ganzen Artikel lesen

J Cutan Med Surg. 2024 Dec 14:12034754241302827. doi: 10.1177/12034754241302827. Online ahead of print. ABSTRACT BACKGROUND: Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis. OBJECTIVES: To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada. METHODS: A multicenter, retrospective study was conducted in Canada in adults with moderate-to-seve

Dermatol Ther (Heidelb). 2024 May 10. doi: 10.1007/s13555-024-01164-6. Online ahead of print. ABSTRACT INTRODUCTION: Real-world data on the efficacy of risankizumab (RZB) in clinical moderate-to-severe plaque psoriasis (PsO) are limited. The RAPID study assessed real-world clinical and patient-reported outcomes in RZB-treated PsO patients using data collected from dermatologists in Canada, the Czech Republic, Germany, Japan, and Poland. METHODS: This ongoing, retrospective chart review collected

J Med Econ. 2025 Jan 14:1-21. doi: 10.1080/13696998.2025.2452054. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is a chronic, systemic, inflammatory skin disease, with increasing prevalence; however, few studies have reported real-world prescription patterns and healthcare burden. OBJECTIVES: This retrospective, observational cohort study used statutory health insurance claims data (January 2014-December 2019) to estimate prevalence/incidence of moderate-to-severe psoriasis in Germany. P

J Nippon Med Sch. 2024;91(6):534-540. doi: 10.1272/jnms.JNMS.2024_91-613. ABSTRACT BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is positively associated with the prevalence and severity of psoriasis. The fibrosis-4 (FIB-4) index was developed to predict significant liver fibrosis. Using the FIB-4 index, the present study evaluated screening data for liver fibrosis, including MASLD, in patients with refractory psoriasis treated with biologics. METHODS: All adult pa

Mil Med. 2024 Apr 11:usae139. doi: 10.1093/milmed/usae139. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis and atopic dermatitis are chronic, immune-mediated skin disorders that are disqualifying for entrance into the military. Both conditions can cause difficulty wearing body armor and other protective equipment when poorly controlled, limiting a service member's ability to train and deploy worldwide. In addition, these conditions may be exacerbated by military service because of increa

Pharmaceutics. 2024 Mar 25;16(4):449. doi: 10.3390/pharmaceutics16040449. ABSTRACT Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessiv

Arch Dermatol Res. 2024 Oct 5;316(9):661. doi: 10.1007/s00403-024-03410-5. ABSTRACT Psoriasis, an inflammatory disease, is largely mediated by T-helper 17 cytokines. We have previously identified the immune system-released activating agent (Israa) as a novel gene that connects the nervous and immune systems. This research aims to investigate the role of the Israa gene in psoriasis in vivo using the imiquimod-induced psoriasis model. We established the model in C57BL/6 wildtype mice, which were t

Sci Rep. 2024 Jul 2;14(1):15121. doi: 10.1038/s41598-024-65902-8. ABSTRACT Interleukin-17A therapeutic inhibitors are among the most effective treatment methods for moderate-to-severe plaque psoriasis (PP). Reflectance confocal microscopy is a non-invasive imaging technique already documented to be beneficial in evaluating the follow-up of PP under treatment with topical actives and phototherapy. This study aimed to assess the epidermal and dermal changes associated with psoriasis and its treatm

Clin Rheumatol. 2025 Jan 14. doi: 10.1007/s10067-024-07267-x. Online ahead of print. ABSTRACT Psoriatic arthritis (PsA) is a chronic and progressive inflammatory arthritis associated with psoriasis, mainly affecting the axial and peripheral joints, characterized by a wide range of complex phenotypes, significant heterogeneity, and a multifactorial etiology. To effectively address the distinct challenges in managing PsA, a pivotal emphasis is placed on clarifying the concept of refractory PsA. He

Int J Med Sci. 2025 Jan 1;22(3):558-564. doi: 10.7150/ijms.102434. eCollection 2025. ABSTRACT Background: Recent studies suggest a potential link between HS and renal dysfunction. Our objective is to assess the correlation between hidradenitis suppurativa (HS) and renal consequences, specifically focusing on acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). Methods: This study was performed based on retrospective cohort design. Electronic medical record

Psoriasis (Auckl). 2024 Dec 31;14:195-206. doi: 10.2147/PTT.S493315. eCollection 2024. ABSTRACT Psoriasis is a chronic inflammatory disease with a complex pathogenesis. Hyperplasia of glycolytic-dependent epidermal keratinocytes (KCs) is a new hallmark of psoriasis pathogenesis. Meanwhile, immune cells undergo metabolic reprogramming similar to KCs. Glycolysis provides energy for the proliferation of KCs, while it also releases lactic acid to facilitate the differentiation of immune cells. In tu

J Cutan Med Surg. 2024 Jun 7:12034754241260023. doi: 10.1177/12034754241260023. Online ahead of print. ABSTRACT There has been a call to action to enhance representation of non-white individuals in dermatology clinical trials. Investigations in differential response to treatment across populations are limited, particularly in conditions of commonality, impact, distinct presentation, and diagnosis in non-white participants, such as atopic dermatitis and psoriasis. This systematic review summarize

J Am Acad Dermatol. 2024 Oct 10:S0190-9622(24)02997-9. doi: 10.1016/j.jaad.2024.09.060. Online ahead of print. NO ABSTRACT PMID:39395444 | DOI:10.1016/j.jaad.2024.09.060 Den ganzen Artikel lesen

An Bras Dermatol. 2025 Jan 9:S0365-0596(24)00252-6. doi: 10.1016/j.abd.2024.05.005. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies. OBJECTIVES: In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week treatment period. METHODS: A double-center retrospective cohort study was conducted, enrolling

Int J Dermatol. 2024 Jun 7. doi: 10.1111/ijd.17303. Online ahead of print. NO ABSTRACT PMID:38847446 | DOI:10.1111/ijd.17303 Den ganzen Artikel lesen

J Dermatolog Treat. 2025 Dec;36(1):2474507. doi: 10.1080/09546634.2025.2474507. Epub 2025 Mar 6. ABSTRACT BACKGROUND: Emerging research suggests that Janus kinase-signal transducer and activator of transcription (JAK-STAT) inhibitors may be associated with a higher risk of serious infection for patients with rheumatoid arthritis. However, there is no consensus on whether JAK inhibitors increase the risk of serious infection in patients with Immune-mediated inflammatory skin diseases (IMISDs). OB

Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May. ABSTRACT Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in th

Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May. ABSTRACT Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in th

Psoriasis (Auckl). 2024 Sep 23;14:115-120. doi: 10.2147/PTT.S490982. eCollection 2024. ABSTRACT The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition known as medication-related osteonecrosis of the jaw (MRONJ). In this article, we present a unique case of MRONJ in a patient with no history of antiresorptive or antiangiogenic drug

Biostatistics. 2024 Oct 27:kxae039. doi: 10.1093/biostatistics/kxae039. Online ahead of print. ABSTRACT In life history analysis of data from cohort studies, it is important to address the process by which participants are identified and selected. Many health studies select or enrol individuals based on whether they have experienced certain health related events, for example, disease diagnosis or some complication from disease. Standard methods of analysis rely on assumptions concerning the inde

J Low Genit Tract Dis. 2024 Sep 2. doi: 10.1097/LGT.0000000000000839. Online ahead of print. ABSTRACT OBJECTIVE: We present a case series of severe vulvovaginal candidiasis in postmenopausal women using sodium-glucose cotransporter-2 inhibitor (SGLT2i) medications for the management of their diabetes mellitus. MATERIALS AND METHODS: Twenty-four cases from a private vulvovaginal specialist clinic are described. RESULTS: All 24 patients were referred with severe and persistent vulvar pruritus, pai

Psoriasis (Auckl). 2025 Jan 10;15:9-22. doi: 10.2147/PTT.S486338. eCollection 2025. ABSTRACT PURPOSE: Patients' treatment expectations significantly influence the effectiveness of medical and pharmacological treatments. This clinical proof-of-concept study aimed to enhance treatment outcomes by targeting positive treatment expectations of psoriasis patients beginning systemic anti-psoriatic therapy with secukinumab, an interleukin (IL)-17A antagonist. PATIENTS AND METHODS: We randomly assigned p