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Balkan Med J. 2024 May 3;41(3):174-185. doi: 10.4274/balkanmedj.galenos.2024.2024-1-96. ABSTRACT BACKGROUND: Psoriasis is a chronic inflammatory skin disease that has no cure. While the specific cause of psoriasis is unknown, interactions between immune cells and inflammatory cytokines are believed to be important in its pathogenesis. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells that profoundly affects dendritic cells (DCs) and is involved in allergy and inflamm

Clin Exp Dermatol. 2024 May 3:llae152. doi: 10.1093/ced/llae152. Online ahead of print. ABSTRACT BACKGROUND: Dysregulated interleukin (IL)-17/IL-23 signaling contributes to psoriasis pathogenesis. Cedirogant is an inverse agonist of retinoic acid-related orphan receptor gamma thymus (RORγt), a key transcription factor responsible for IL-17 synthesis and a regulator of the T helper 17 cell lineage program. OBJECTIVE: To evaluate the efficacy and safety of cedirogant to treat moderate-to-severe ps

Expert Opin Drug Saf. 2024 May 3. doi: 10.1080/14740338.2024.2351462. Online ahead of print. ABSTRACT INTRODUCTION: Nowadays, despite the wide availability of biological drugs and apremilast for psoriasis management, there is always a need for new therapies to customize the therapeutic approach on the basis of the patient's clinical features and comorbidities, especially in order to achieve a prolonged therapeutic response. Thus, new treatment strategies are required to offer patients a personal

J Clin Periodontol. 2024 May 3. doi: 10.1111/jcpe.13996. Online ahead of print. ABSTRACT AIM: To investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature- and imiquimod-induced diseases on murine models. MATERIALS AND METHODS: Thirty-two C57/BL6J mice were randomly allocated to four experimental groups: control (P- Pso-), ligature-induced periodontitis (P+ Pso-), imiquimod-induced psoriasis (P- Pso+) and periodontitis and p

Front Genet. 2024 Apr 18;15:1365273. doi: 10.3389/fgene.2024.1365273. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis represents a multifaceted and debilitating immune-mediated systemic ailment afflicting millions globally. Despite the continuous discovery of biomarkers associated with psoriasis, identifying lysosomal biomarkers, pivotal as cellular metabolic hubs, remains elusive. METHODS: We employed a combination of differential expression analysis and weighted gene co-expression network ana

Rheumatol Adv Pract. 2024 Apr 10;8(2):rkae052. doi: 10.1093/rap/rkae052. eCollection 2024. NO ABSTRACT PMID:38698954 | PMC:PMC11065474 | DOI:10.1093/rap/rkae052 Den ganzen Artikel lesen

Pharmaceutics. 2024 Mar 26;16(4):458. doi: 10.3390/pharmaceutics16040458. ABSTRACT The aim of this review is to provide a summary of the botany, phytochemistry and dermatological effects of Punica granatum (PG), with special emphasis on therapeutic mechanisms in various skin conditions. PG peel contains the highest levels of chemical compounds. Due to the high abundance of polyphenolic compounds, including phenolic acids, anthocyanins and flavonoids, exhibiting strong antioxidant properties, PG

Pharmaceutics. 2024 Mar 25;16(4):449. doi: 10.3390/pharmaceutics16040449. ABSTRACT Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessiv

Genes (Basel). 2024 Mar 22;15(4):393. doi: 10.3390/genes15040393. ABSTRACT Autoimmunity is defined as the inability to regulate immunological activities in the body, especially in response to external triggers, leading to the attack of the tissues and organs of the host. Outcomes include the onset of autoimmune diseases whose effects are primarily due to dysregulated immune responses. In past years, there have been cases that show an increased susceptibility to other autoimmune disorders in pati

Medicina (Kaunas). 2024 Mar 31;60(4):579. doi: 10.3390/medicina60040579. ABSTRACT Background and Objectives: Tuberculosis is caused by Mycobacterium tuberculosis (MTB), while nontuberculous mycobacteria (NTM) encompass a group of mycobacterial species that are distinct from the MTB complex and leprae. Spondyloarthritis (SpA) is a group of chronic inflammatory diseases with shared clinical characteristics and is treated with biological agents; however, their use may elevate the risk of MTB and NT

Int J Mol Sci. 2024 Apr 21;25(8):4545. doi: 10.3390/ijms25084545. ABSTRACT IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is member of the IQGAP family of scaffold proteins, which are essential for assembling multiprotein complexes that coordinate various intracellular signaling pathways. Previous research has shown that IQGAP3 is overexpressed in psoriatic skin lesions. Given its involvement in processes like cell proliferation and chemokine signaling, we sought to explore its molecul

J Clin Med. 2024 Apr 22;13(8):2441. doi: 10.3390/jcm13082441. ABSTRACT Background: The care of psoriatic patients requires a multidisciplinary approach that addresses not only skin involvement but also cardiovascular risk factors. Coordination between dermatology and internal medicine departments, with a specific focus on treatment and long-term follow-up, can substantially improve the course of a disease and its associated complications. Objective: to evaluate the effects of the holistic manage

J Clin Med. 2024 Apr 12;13(8):2250. doi: 10.3390/jcm13082250. ABSTRACT Background/Objectives: Treating psoriasis patients requires the consideration of potential underlying complications like latent viral infections and chronic kidney disease, which may influence therapy selection. Case presentation: A patient with end-stage kidney disease (ESKD) undergoing hemodialysis (HD) was successfully treated with bimekizumab, an IgG1 humanized monoclonal antibody inhibiting interleukin (IL)-17A and IL-17

J Pers Med. 2024 Apr 17;14(4):427. doi: 10.3390/jpm14040427. ABSTRACT (1) Background: Although the association between psoriasis and atopic dermatitis (AD) is reported in the literature, scarce data are known about the efficacy of biologic therapy (including TNF and IL-17 inhibitors) in patients with psoriatic arthritis (PsA) and concomitant AD. (2) Objective: We aimed to explore AD in patients with PsA undergoing biologics for their active disease, focusing on prevalence and clinical and potent

Life (Basel). 2024 Apr 16;14(4):516. doi: 10.3390/life14040516. ABSTRACT Immuno-correlated dermatological pathologies refer to skin disorders that are closely associated with immune system dysfunction or abnormal immune responses. Advancements in the field of artificial intelligence (AI) have shown promise in enhancing the diagnosis, management, and assessment of immuno-correlated dermatological pathologies. This intersection of dermatology and immunology plays a pivotal role in comprehending an

Life (Basel). 2024 Apr 10;14(4):492. doi: 10.3390/life14040492. ABSTRACT Skin conditions are numerous and often have a major impact on patients' quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial products that can induce various side effects, especially with long-term use, which is why researchers are studying alternatives, especially biologically active natural products. Three products

Sci Rep. 2024 Apr 27;14(1):9715. doi: 10.1038/s41598-024-60526-4. ABSTRACT The tendency of skin diseases to manifest in a unique and yet similar appearance, absence of enough competent dermatologists, and urgency of diagnosis and classification on time and accurately, makes the need of machine aided diagnosis blatant. This study is conducted with the purpose of broadening the research in skin disease diagnosis with computer by traversing the capabilities of deep Learning algorithms to classify t

J Am Acad Dermatol. 2024 Apr 25:S0190-9622(24)00654-6. doi: 10.1016/j.jaad.2024.03.048. Online ahead of print. NO ABSTRACT PMID:38677338 | DOI:10.1016/j.jaad.2024.03.048 Den ganzen Artikel lesen

Biomolecules. 2024 Apr 11;14(4):469. doi: 10.3390/biom14040469. ABSTRACT Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous research demonstrated the effectiveness of small spleen peptides (SSPs) in inhibiting psoriatic arthritis progression, even in the presence of the pro-inflammatory cytokine TNFα, by transfo

Biomedicines. 2024 Mar 25;12(4):732. doi: 10.3390/biomedicines12040732. ABSTRACT Psoriasis, a prevalent inflammatory skin disorder affecting a significant percentage of the global population, poses challenges in its management, necessitating the exploration of novel cost-effective and widely accessible therapeutic options. This study investigates the potential of ursolic acid (UA), a triterpenoid known for its anti-inflammatory and pro-apoptotic properties, in addressing psoriasis-related inflam

Antioxidants (Basel). 2024 Mar 30;13(4):425. doi: 10.3390/antiox13040425. ABSTRACT Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also k

Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831. ABSTRACT Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histo

Int J Mol Sci. 2024 Mar 29;25(7):3823. doi: 10.3390/ijms25073823. ABSTRACT Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace elements are zinc, copper, and iron. A deficiency or excess of trace elements can be associated with an increased risk of skin diseases, so increasing their supplementation or limiting intake can be helpful in dermatological treatment. In addition, determinati

Int J Mol Sci. 2024 Mar 23;25(7):3617. doi: 10.3390/ijms25073617. ABSTRACT Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin

Molecules. 2024 Mar 29;29(7):1540. doi: 10.3390/molecules29071540. ABSTRACT Aquaporin 3 (AQP3) channels are tetrameric membrane-bound channels that facilitate the transport of water and other small solutes across cell membranes in the skin. Decreased AQP3 expression is associated with skin dryness, skin aging, psoriasis, and delayed wound healing. Thus, our study focused on a novel combination based on Aloe barbadensis leaf extract and trimethylglycine for targeted AQP3 regulation in skin kerati