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Antioxidants (Basel). 2024 Mar 30;13(4):425. doi: 10.3390/antiox13040425. ABSTRACT Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also k

Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831. ABSTRACT Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histo

Int J Mol Sci. 2024 Mar 29;25(7):3823. doi: 10.3390/ijms25073823. ABSTRACT Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace elements are zinc, copper, and iron. A deficiency or excess of trace elements can be associated with an increased risk of skin diseases, so increasing their supplementation or limiting intake can be helpful in dermatological treatment. In addition, determinati

Int J Mol Sci. 2024 Mar 23;25(7):3617. doi: 10.3390/ijms25073617. ABSTRACT Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin

Molecules. 2024 Mar 29;29(7):1540. doi: 10.3390/molecules29071540. ABSTRACT Aquaporin 3 (AQP3) channels are tetrameric membrane-bound channels that facilitate the transport of water and other small solutes across cell membranes in the skin. Decreased AQP3 expression is associated with skin dryness, skin aging, psoriasis, and delayed wound healing. Thus, our study focused on a novel combination based on Aloe barbadensis leaf extract and trimethylglycine for targeted AQP3 regulation in skin kerati

J Clin Med. 2024 Mar 27;13(7):1940. doi: 10.3390/jcm13071940. ABSTRACT Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evid

Nanomaterials (Basel). 2024 Mar 29;14(7):610. doi: 10.3390/nano14070610. ABSTRACT Psoriasis, a chronic inflammatory skin disease induced by various factors, including genetic factors, immune factors, environmental factors, and psychological factors, is characterized by thickening of the epidermis, excessive proliferation of keratinocytes, abnormal differentiation, and an excessive inflammatory response. Traditional treatments for psoriasis still face challenges because of limited curative effect

Front Pharmacol. 2024 Mar 28;15:1369805. doi: 10.3389/fphar.2024.1369805. eCollection 2024. ABSTRACT Dose reduction (DR) of first-generation biologics for plaque psoriasis (TNF-alpha inhibitors (i) and interleukin (IL)-12/23i) has been described in a previous scoping review. The literature on the DR of the newest generation of biologics (IL-17/23i) was scarce. The current review provides a literature update on the previous scoping review on the DR of all biologics, including the newest generatio

Front Med (Lausanne). 2024 Mar 28;11:1335551. doi: 10.3389/fmed.2024.1335551. eCollection 2024. ABSTRACT As chronic inflammatory conditions driven by immune dysregulation are influenced by genetics and environment factors, psoriasis and atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized by different T cell responses. Psoriasis, associated with type 17 helper T (Th17)-mediated inflammation, presents as well-defined scaly plaques with minimal pruritus.

Front Oncol. 2024 Mar 28;14:1331419. doi: 10.3389/fonc.2024.1331419. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fonc.2023.1185389.]. PMID:38606107 | PMC:PMC11008677 | DOI:10.3389/fonc.2024.1331419 Den ganzen Artikel lesen

Front Immunol. 2024 Mar 28;15:1304888. doi: 10.3389/fimmu.2024.1304888. eCollection 2024. ABSTRACT BACKGROUND: Prior research has indicated a link between psoriasis and the susceptibility to breast cancer (BC); however, a definitive causal relationship remains elusive. This study sought to elucidate the causal connection and shared underlying mechanisms between psoriasis and BC through bidirectional Mendelian randomization (MR) and bioinformatic approaches. METHODS: We employed a bidirectional M

Phenomics. 2023 Aug 21;4(1):46-50. doi: 10.1007/s43657-023-00110-4. eCollection 2024 Feb. ABSTRACT Commonly affected in early-life population, the impact of allergic phenotypes on mid- or late-life health is less discussed. This study is to explore the association of allergic phenotypes including atopic dermatitis (AD), asthma, eosinophils count (EC), and sarcopenia. We conducted observational studies and mendelian randomization (MR) analysis based on UK Biobank (UKB), the China Health and Retir

Front Public Health. 2024 Mar 28;12:1333811. doi: 10.3389/fpubh.2024.1333811. eCollection 2024. ABSTRACT BACKGROUND: In recent years, an increasing number of observational studies have reported the impact of air pollution on autoimmune diseases (ADs). However, no Mendelian randomization (MR) studies have been conducted to investigate the causal relationships. To enhance our understanding of causality, we examined the causal relationships between particulate matter (PM) and nitrogen oxides (NOx)

Tob Induc Dis. 2024 Apr 11;22. doi: 10.18332/tid/184143. eCollection 2024. ABSTRACT INTRODUCTION: Smoking is an independent and modifiable risk factor for the onset and development of psoriasis; however, evidence on the association between tobacco smoking and psoriasis treatment efficacy is limited. This study aimed to explore the influence of smoking on treatment efficacy in a cohort of patients with psoriasis in Shanghai, China. METHODS: Patients with psoriasis were recruited from the Shanghai

BMC Cancer. 2024 Apr 12;24(1):458. doi: 10.1186/s12885-024-12188-8. ABSTRACT BACKGROUND: The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to predict prognosis for acute myeloid leukemia (AML). METHODS: 952 patients with pathologically-confirmed AML were retrospectively enrolled between 2010 and 2020. CT-derived features (including body composit

J Am Acad Dermatol. 2024 Apr 10:S0190-9622(24)00626-1. doi: 10.1016/j.jaad.2024.02.062. Online ahead of print. NO ABSTRACT PMID:38608866 | DOI:10.1016/j.jaad.2024.02.062 Den ganzen Artikel lesen

Int Immunopharmacol. 2024 Apr 11;133:112033. doi: 10.1016/j.intimp.2024.112033. Online ahead of print. ABSTRACT Psoriasis is an immuno-inflammatory disease characterized by excessive keratinocyte proliferation, requiring extensive lipids. 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1) is an essential enzyme in the mevalonate pathway, involved in cholesterol synthesis and the inflammatory response. However, the role of HMGCS1 in psoriasis has remained elusive. This study aims to elucid

Mil Med. 2024 Apr 11:usae139. doi: 10.1093/milmed/usae139. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis and atopic dermatitis are chronic, immune-mediated skin disorders that are disqualifying for entrance into the military. Both conditions can cause difficulty wearing body armor and other protective equipment when poorly controlled, limiting a service member's ability to train and deploy worldwide. In addition, these conditions may be exacerbated by military service because of increa

Adv Rheumatol. 2024 Apr 11;64(1):25. doi: 10.1186/s42358-024-00367-x. ABSTRACT BACKGROUND: Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy. METHODS: A cross-sectional

Asian J Surg. 2024 Apr 10:S1015-9584(24)00605-5. doi: 10.1016/j.asjsur.2024.03.178. Online ahead of print. NO ABSTRACT PMID:38604866 | DOI:10.1016/j.asjsur.2024.03.178 Den ganzen Artikel lesen

Australas J Dermatol. 2024 Apr 10. doi: 10.1111/ajd.14266. Online ahead of print. NO ABSTRACT PMID:38597123 | DOI:10.1111/ajd.14266 Den ganzen Artikel lesen

Front Immunol. 2024 Mar 26;15:1374763. doi: 10.3389/fimmu.2024.1374763. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated disorder influenced by environmental factors on a genetic basis. Despite advancements, challenges persist, including the diminishing efficacy of biologics and small-molecule targeted agents, alongside managing recurrence and psoriasis-related comorbidities. Unraveling the underlying pathogenesis and identifying valuable biomarkers remain pivotal for diagn

Curr Med Res Opin. 2024 Apr 10:1-13. doi: 10.1080/03007995.2024.2340720. Online ahead of print. ABSTRACT OBJECTIVE: Effective health communication is critical for understanding and acting on health information. This cross-sectional study explored participants' understanding of their health condition, their preferences for receiving health communications, and their interest in receiving clinical trial results across several therapeutic areas. METHODS: The study recruited participants via social m

Indian J Dermatol Venereol Leprol. 2024 Mar 19:1-7. doi: 10.25259/IJDVL_631_2023. Online ahead of print. ABSTRACT Background Chronic childhood diseases are a burden for paediatric patients and their caregivers. Limited data are available on the effect of paediatric psoriasis on the caregiver's well-being and quality of life. Objective To assess the impact of childhood and adolescent chronic plaque psoriasis on parents/caregivers quality of life. Methods A single-centre cross-sectional study was

Indian J Dermatol Venereol Leprol. 2024 Apr 2:1-9. doi: 10.25259/IJDVL_719_2023. Online ahead of print. ABSTRACT Background The paradoxical occurrence of psoriasis triggered by Interleukin-17 (IL-17) inhibitors is notable due to its prominent symptoms and the therapeutic dilemma it presents for follow-up care. Objective To describe cases in our clinic, perform an in-depth literature review, and suggest the most probable mechanisms of action. Method We conducted a literature review on published c