Aus Pubmed

PLoS One. 2024 May 10;19(5):e0303058. doi: 10.1371/journal.pone.0303058. eCollection 2024. ABSTRACT BACKGROUND: Shared decision-making (SDM) refers to a collaborative process in which clinicians assist patients in making medically informed, evidence-based decisions that align with their values and preferences. There is a paucity of literature on SDM in dermatology. OBJECTIVE: We aim to assess whether male and female psoriasis patients evaluate their clinicians' engagement in SDM differently acro

Cureus. 2024 Sep 3;16(9):e68569. doi: 10.7759/cureus.68569. eCollection 2024 Sep. ABSTRACT Psoriasis (PS) and inflammatory bowel disease (IBD) are immune-mediated chronic conditions that share pathophysiological processes, including immune system dysfunction, microbiome dysbiosis, and inflammatory pathways. These pathways result in increased turnover of epithelial cells and compromised barrier function. The assessment of the literature suggests that immunopathogenic mechanisms, such as tumor nec

Sci Rep. 2024 Oct 11;14(1):23794. doi: 10.1038/s41598-024-75833-z. ABSTRACT Assessment of side effects associated with COVID-19 vaccination is required to monitor safety issues and acceptance of vaccines in the long term. We found a significant knowledge gap in the safety profile of COVID-19 vaccines in Bangladesh. We enrolled 1805 vaccine recipients from May 5, 2021, to April 4, 2023. Kruskal-Wallis test and χ2 test were performed. Multivariable logistic regression was also performed. First, se

Front Genet. 2024 Apr 18;15:1365273. doi: 10.3389/fgene.2024.1365273. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis represents a multifaceted and debilitating immune-mediated systemic ailment afflicting millions globally. Despite the continuous discovery of biomarkers associated with psoriasis, identifying lysosomal biomarkers, pivotal as cellular metabolic hubs, remains elusive. METHODS: We employed a combination of differential expression analysis and weighted gene co-expression network ana

J Immunol. 2024 Jun 10:ji2300752. doi: 10.4049/jimmunol.2300752. Online ahead of print. ABSTRACT Psoriasis is a common inflammatory skin disorder with no cure. Mesenchymal stem cells (MSCs) have immunomodulatory properties for psoriasis, but the therapeutic efficacies varied, and the molecular mechanisms were unknown. In this study, we improved the efficacy by enhancing the immunomodulatory effects of umbilical cord-derived MSCs (UC-MSCs). UC-MSCs stimulated by TNF-α and IFN-γ exhibited a better

Front Immunol. 2024 Mar 26;15:1374763. doi: 10.3389/fimmu.2024.1374763. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated disorder influenced by environmental factors on a genetic basis. Despite advancements, challenges persist, including the diminishing efficacy of biologics and small-molecule targeted agents, alongside managing recurrence and psoriasis-related comorbidities. Unraveling the underlying pathogenesis and identifying valuable biomarkers remain pivotal for diagn

J Control Release. 2025 Jan 3:S0168-3659(25)00003-3. doi: 10.1016/j.jconrel.2025.01.001. Online ahead of print. ABSTRACT The immunosuppressive tumor microenvironment (TME) plays a crucial role in the progression and treatment resistance of melanoma. Modulating the TME is thus a key strategy for enhancing therapeutic outcomes. Recent studies have identified clonidine (CLD), an α2-adrenergic receptor agonist, as a promising agent that enhances T lymphocyte infiltration and reduces myeloid-derived

Front Med (Lausanne). 2024 Mar 28;11:1335551. doi: 10.3389/fmed.2024.1335551. eCollection 2024. ABSTRACT As chronic inflammatory conditions driven by immune dysregulation are influenced by genetics and environment factors, psoriasis and atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized by different T cell responses. Psoriasis, associated with type 17 helper T (Th17)-mediated inflammation, presents as well-defined scaly plaques with minimal pruritus.

Int J Mol Sci. 2024 Dec 28;26(1):179. doi: 10.3390/ijms26010179. ABSTRACT Growing scientific evidence suggests a strong interconnection between inflammatory skin diseases and osteoporosis (OP), a systemic condition characterized by decreased bone density and structural fragility. These conditions seem to share common pathophysiological mechanisms, including immune dysregulation, chronic inflammation, and vitamin D deficiency, which play a crucial role in both skin and bone health. Additionally,

J Inflamm Res. 2025 Jan 10;18:505-517. doi: 10.2147/JIR.S493338. eCollection 2025. ABSTRACT PURPOSE: Psoriasis is a complex inflammatory skin disorder that is closely associated with metabolic syndrome (MetS). Limited information is available on skin metabolic changes in psoriasis; the effect of concurrent MetS on psoriatic skin metabolite levels is unknown. We aimed to expand this information through skin metabolomic analysis. PATIENTS AND METHODS: Untargeted metabolomics was conducted using sk

Skin Res Technol. 2024 Sep;30(9):e70035. doi: 10.1111/srt.70035. ABSTRACT BACKGROUND: Atopic dermatitis (AD), psoriasis (PSO), rosacea, and other related immune skin diseases are affected by multiple complex factors such as genetic and microbial components. This research investigates the causal relationships between specific skin microbiota and these diseases by using Mendelian randomization (MR), and Bayesian weighted Mendelian randomization (BWMR). METHODS: We utilized genome-wide association

Biomolecules. 2024 Apr 11;14(4):469. doi: 10.3390/biom14040469. ABSTRACT Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous research demonstrated the effectiveness of small spleen peptides (SSPs) in inhibiting psoriatic arthritis progression, even in the presence of the pro-inflammatory cytokine TNFα, by transfo

Prim Care Companion CNS Disord. 2025 Jan 9;27(1):24cr03803. doi: 10.4088/PCC.24cr03803. NO ABSTRACT PMID:39823455 | DOI:10.4088/PCC.24cr03803 Den ganzen Artikel lesen

Acta Pharm Sin B. 2024 Jun;14(6):2646-2656. doi: 10.1016/j.apsb.2024.02.002. Epub 2024 Feb 20. ABSTRACT Tumor necrosis factor-α (TNF-α) is a promising target for inflammatory and autoimmune diseases. Spirohypertones A (1) and B (2), two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skeletons, were isolated from Hypericum patulum. The structures of 1 and 2 were confirmed through comprehensive spectroscopic analysis, single-crystal X-ray diffraction and electro

Life (Basel). 2024 Oct 6;14(10):1271. doi: 10.3390/life14101271. ABSTRACT Autofluorescence is a remarkable property of human skin. It can be excited by UV and observed in the dark using special detection systems. The method of fluorescence photography (FP) is an effective non-invasive tool for skin assessment. It involves image capturing by a camera the emission of light quanta from fluorophore molecules in the skin. It serves as a useful tool for cosmetic and skincare research, especially for t

Arch Dermatol Res. 2024 Dec 14;317(1):125. doi: 10.1007/s00403-024-03607-8. ABSTRACT The genetic causality between cathepsin levels and autoimmune diseases (ADs) bidirectionally was investigated and the associated cancer risk was explored with Mendelian randomization. Mendelian randomization analyses were used to explore causal associations between cathepsin and 14 ADs. The final results came from a meta-analysis of two datasets to get a robust result. Furthermore, the potential carcinogenic eff

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17469. Online ahead of print. NO ABSTRACT PMID:39349364 | DOI:10.1111/1346-8138.17469 Den ganzen Artikel lesen

J Clin Med. 2024 Apr 12;13(8):2250. doi: 10.3390/jcm13082250. ABSTRACT Background/Objectives: Treating psoriasis patients requires the consideration of potential underlying complications like latent viral infections and chronic kidney disease, which may influence therapy selection. Case presentation: A patient with end-stage kidney disease (ESKD) undergoing hemodialysis (HD) was successfully treated with bimekizumab, an IgG1 humanized monoclonal antibody inhibiting interleukin (IL)-17A and IL-17

J Dtsch Dermatol Ges. 2024 Apr 9. doi: 10.1111/ddg.15364. Online ahead of print. NO ABSTRACT PMID:38593343 | DOI:10.1111/ddg.15364 Den ganzen Artikel lesen

J Dermatolog Treat. 2024 Dec;35(1):2411849. doi: 10.1080/09546634.2024.2411849. Epub 2024 Oct 6. ABSTRACT Background and objectives: Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder affecting 30% of psoriatic patients. Effective treatment, especially with biologics like IL-17 and TNF inhibitors, is vital for improving patient outcomes. This study aimed to compare the efficacy of secukinumab and adalimumab in PsA patients through clinical and ultrasonographic evaluatio

RMD Open. 2024 Dec 12;10(4):e004494. doi: 10.1136/rmdopen-2024-004494. ABSTRACT OBJECTIVES: To prospectively evaluate the effect of guselkumab through 48 weeks across various clinical outcomes in subgroups of patients with psoriatic arthritis (PsA) and inadequate response to tumour necrosis factor inhibitors (TNFi-IR) from the phase 3b COSMOS trial. Subgroups were defined by baseline demographics, disease characteristics and prior/ongoing therapies. METHODS: Patients with active PsA (tender join

Australas J Dermatol. 2024 Apr 10. doi: 10.1111/ajd.14266. Online ahead of print. NO ABSTRACT PMID:38597123 | DOI:10.1111/ajd.14266 Den ganzen Artikel lesen

Molecules. 2024 Mar 29;29(7):1540. doi: 10.3390/molecules29071540. ABSTRACT Aquaporin 3 (AQP3) channels are tetrameric membrane-bound channels that facilitate the transport of water and other small solutes across cell membranes in the skin. Decreased AQP3 expression is associated with skin dryness, skin aging, psoriasis, and delayed wound healing. Thus, our study focused on a novel combination based on Aloe barbadensis leaf extract and trimethylglycine for targeted AQP3 regulation in skin kerati

Sci Rep. 2024 Oct 12;14(1):23866. doi: 10.1038/s41598-024-72951-6. ABSTRACT The purpose of the current work was to develop and characterize ethosomes of vitamin D3 gel that could more effectively work against psoriasis. Psoriasis is a chronic immune-mediated inflammatory skin disease. Due to vitamin D3 role in proliferation and maturation of keratinocytes, it has become an important local therapeutic option in the treatment of psoriasis. In this research we have initiated worked on ethosomes gel

Chem Pharm Bull (Tokyo). 2025;73(1):1-17. doi: 10.1248/cpb.c24-00598. ABSTRACT 2α-Functionalization of 1α,25-dihydroxyvitamin D3 (active vitamin D3) A-ring enhances binding affinity for the vitamin D receptor (VDR) and prolongs the half-life in target cells due to gaining resistance to CYP24A1-dependant metabolism. The wide variety of modified A-ring precursor enynes for Trost coupling with CD-ring bromoolefin were synthesized from d-glucose. The A-ring modification provided potent, selective bi