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J Clin Med. 2024 Mar 27;13(7):1940. doi: 10.3390/jcm13071940. ABSTRACT Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evid

Nanomaterials (Basel). 2024 Mar 29;14(7):610. doi: 10.3390/nano14070610. ABSTRACT Psoriasis, a chronic inflammatory skin disease induced by various factors, including genetic factors, immune factors, environmental factors, and psychological factors, is characterized by thickening of the epidermis, excessive proliferation of keratinocytes, abnormal differentiation, and an excessive inflammatory response. Traditional treatments for psoriasis still face challenges because of limited curative effect

Front Pharmacol. 2024 Mar 28;15:1369805. doi: 10.3389/fphar.2024.1369805. eCollection 2024. ABSTRACT Dose reduction (DR) of first-generation biologics for plaque psoriasis (TNF-alpha inhibitors (i) and interleukin (IL)-12/23i) has been described in a previous scoping review. The literature on the DR of the newest generation of biologics (IL-17/23i) was scarce. The current review provides a literature update on the previous scoping review on the DR of all biologics, including the newest generatio

Front Med (Lausanne). 2024 Mar 28;11:1335551. doi: 10.3389/fmed.2024.1335551. eCollection 2024. ABSTRACT As chronic inflammatory conditions driven by immune dysregulation are influenced by genetics and environment factors, psoriasis and atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized by different T cell responses. Psoriasis, associated with type 17 helper T (Th17)-mediated inflammation, presents as well-defined scaly plaques with minimal pruritus.

Front Oncol. 2024 Mar 28;14:1331419. doi: 10.3389/fonc.2024.1331419. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fonc.2023.1185389.]. PMID:38606107 | PMC:PMC11008677 | DOI:10.3389/fonc.2024.1331419 Den ganzen Artikel lesen

Front Immunol. 2024 Mar 28;15:1304888. doi: 10.3389/fimmu.2024.1304888. eCollection 2024. ABSTRACT BACKGROUND: Prior research has indicated a link between psoriasis and the susceptibility to breast cancer (BC); however, a definitive causal relationship remains elusive. This study sought to elucidate the causal connection and shared underlying mechanisms between psoriasis and BC through bidirectional Mendelian randomization (MR) and bioinformatic approaches. METHODS: We employed a bidirectional M

Phenomics. 2023 Aug 21;4(1):46-50. doi: 10.1007/s43657-023-00110-4. eCollection 2024 Feb. ABSTRACT Commonly affected in early-life population, the impact of allergic phenotypes on mid- or late-life health is less discussed. This study is to explore the association of allergic phenotypes including atopic dermatitis (AD), asthma, eosinophils count (EC), and sarcopenia. We conducted observational studies and mendelian randomization (MR) analysis based on UK Biobank (UKB), the China Health and Retir

Front Public Health. 2024 Mar 28;12:1333811. doi: 10.3389/fpubh.2024.1333811. eCollection 2024. ABSTRACT BACKGROUND: In recent years, an increasing number of observational studies have reported the impact of air pollution on autoimmune diseases (ADs). However, no Mendelian randomization (MR) studies have been conducted to investigate the causal relationships. To enhance our understanding of causality, we examined the causal relationships between particulate matter (PM) and nitrogen oxides (NOx)

Tob Induc Dis. 2024 Apr 11;22. doi: 10.18332/tid/184143. eCollection 2024. ABSTRACT INTRODUCTION: Smoking is an independent and modifiable risk factor for the onset and development of psoriasis; however, evidence on the association between tobacco smoking and psoriasis treatment efficacy is limited. This study aimed to explore the influence of smoking on treatment efficacy in a cohort of patients with psoriasis in Shanghai, China. METHODS: Patients with psoriasis were recruited from the Shanghai

BMC Cancer. 2024 Apr 12;24(1):458. doi: 10.1186/s12885-024-12188-8. ABSTRACT BACKGROUND: The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to predict prognosis for acute myeloid leukemia (AML). METHODS: 952 patients with pathologically-confirmed AML were retrospectively enrolled between 2010 and 2020. CT-derived features (including body composit

J Am Acad Dermatol. 2024 Apr 10:S0190-9622(24)00626-1. doi: 10.1016/j.jaad.2024.02.062. Online ahead of print. NO ABSTRACT PMID:38608866 | DOI:10.1016/j.jaad.2024.02.062 Den ganzen Artikel lesen

Int Immunopharmacol. 2024 Apr 11;133:112033. doi: 10.1016/j.intimp.2024.112033. Online ahead of print. ABSTRACT Psoriasis is an immuno-inflammatory disease characterized by excessive keratinocyte proliferation, requiring extensive lipids. 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1) is an essential enzyme in the mevalonate pathway, involved in cholesterol synthesis and the inflammatory response. However, the role of HMGCS1 in psoriasis has remained elusive. This study aims to elucid

Mil Med. 2024 Apr 11:usae139. doi: 10.1093/milmed/usae139. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis and atopic dermatitis are chronic, immune-mediated skin disorders that are disqualifying for entrance into the military. Both conditions can cause difficulty wearing body armor and other protective equipment when poorly controlled, limiting a service member's ability to train and deploy worldwide. In addition, these conditions may be exacerbated by military service because of increa

Adv Rheumatol. 2024 Apr 11;64(1):25. doi: 10.1186/s42358-024-00367-x. ABSTRACT BACKGROUND: Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy. METHODS: A cross-sectional

Asian J Surg. 2024 Apr 10:S1015-9584(24)00605-5. doi: 10.1016/j.asjsur.2024.03.178. Online ahead of print. NO ABSTRACT PMID:38604866 | DOI:10.1016/j.asjsur.2024.03.178 Den ganzen Artikel lesen

Australas J Dermatol. 2024 Apr 10. doi: 10.1111/ajd.14266. Online ahead of print. NO ABSTRACT PMID:38597123 | DOI:10.1111/ajd.14266 Den ganzen Artikel lesen

Front Immunol. 2024 Mar 26;15:1374763. doi: 10.3389/fimmu.2024.1374763. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated disorder influenced by environmental factors on a genetic basis. Despite advancements, challenges persist, including the diminishing efficacy of biologics and small-molecule targeted agents, alongside managing recurrence and psoriasis-related comorbidities. Unraveling the underlying pathogenesis and identifying valuable biomarkers remain pivotal for diagn

Curr Med Res Opin. 2024 Apr 10:1-13. doi: 10.1080/03007995.2024.2340720. Online ahead of print. ABSTRACT OBJECTIVE: Effective health communication is critical for understanding and acting on health information. This cross-sectional study explored participants' understanding of their health condition, their preferences for receiving health communications, and their interest in receiving clinical trial results across several therapeutic areas. METHODS: The study recruited participants via social m

Indian J Dermatol Venereol Leprol. 2024 Mar 19:1-7. doi: 10.25259/IJDVL_631_2023. Online ahead of print. ABSTRACT Background Chronic childhood diseases are a burden for paediatric patients and their caregivers. Limited data are available on the effect of paediatric psoriasis on the caregiver's well-being and quality of life. Objective To assess the impact of childhood and adolescent chronic plaque psoriasis on parents/caregivers quality of life. Methods A single-centre cross-sectional study was

Indian J Dermatol Venereol Leprol. 2024 Apr 2:1-9. doi: 10.25259/IJDVL_719_2023. Online ahead of print. ABSTRACT Background The paradoxical occurrence of psoriasis triggered by Interleukin-17 (IL-17) inhibitors is notable due to its prominent symptoms and the therapeutic dilemma it presents for follow-up care. Objective To describe cases in our clinic, perform an in-depth literature review, and suggest the most probable mechanisms of action. Method We conducted a literature review on published c

Int J Dermatol. 2024 Apr 9. doi: 10.1111/ijd.17146. Online ahead of print. ABSTRACT BACKGROUND: Social comparison, the process of evaluating one's characteristics in relation to others, influences individuals' self-perception and behavior. However, instruments are scarce for assessing social comparison in the medical setting. OBJECTIVES: Our aim was to develop and validate a new scale for assessing social comparison. MATERIALS AND METHODS: Seven statements were developed, encompassing the percei

Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print. ABSTRACT Interleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or infla

JAMA Dermatol. 2024 Apr 10. doi: 10.1001/jamadermatol.2024.0257. Online ahead of print. ABSTRACT IMPORTANCE: There is no US Food and Drug Administration-approved treatment for pityriasis rubra pilaris (PRP), and it is common for patients to fail to experience improvement with several systemic options. Involvement of interleukin (IL) 23 suggests a potential therapeutic target. OBJECTIVE: To determine whether guselkumab, an IL-23p19 inhibitor, provides clinical improvement for participants with PR

Rheumatol Int. 2024 Apr 10. doi: 10.1007/s00296-024-05576-7. Online ahead of print. ABSTRACT Global health (GH) and health-related quality of life are patient priorities in axial spondyloarthritis (axSpA). Our objective was to assess the relative importance of disease-related factors including disease activity, and patient-related factors including comorbidities, to explain GH in axSpA. Post hoc cross-sectional analyses of 4 sets (COMOSPA, PERSPA, COMEDSPA, and DESIR) of patients fulfilling ASAS

Endocrinol Diabetes Metab. 2024 May;7(3):e00476. doi: 10.1002/edm2.476. ABSTRACT OBJECTIVE: Onset and exacerbation of autoimmune, inflammatory or steroid-responsive conditions have been reported following the remission of Cushing syndrome, leading to challenges in distinguishing a new condition versus expected symptomatology following remission. We describe a case of a 42-year-old man presenting with new-onset sarcoidosis diagnosed 12 months following the surgical cure of Cushing syndrome and sy