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Sci Adv. 2024 Jul 5;10(27):eado2365. doi: 10.1126/sciadv.ado2365. Epub 2024 Jul 3. ABSTRACT Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease with a poorly understood pathogenesis. Through a molecularly driven precision medicine approach and an extensive mechanistic pathway analysis in PRP skin samples, compared to psoriasis, atopic dermatitis, healed PRP, and healthy controls, we identified IL-1β as a key mediator, orchestrating an NF-κB-mediated IL-1β-CCL20 axis, including act

Dermatol Ther (Heidelb). 2024 May 3. doi: 10.1007/s13555-024-01160-w. Online ahead of print. ABSTRACT INTRODUCTION: Since during the COVID-19 pandemic nail psoriasis was evaluated exclusively with teledermatology, dermatologists started to face the difficulty in rating it concurrent with other onycopathies (i.e., onychotillomania and onychophagy). Thus, we aimed to improve the existing severity scores and verify the value in different clinical settings (i.e., in person vs. teledermatology (video

J Clin Aesthet Dermatol. 2024 Oct;17(10):18. NO ABSTRACT PMID:39445327 | PMC:PMC11495167 Den ganzen Artikel lesen

Medicina (Kaunas). 2024 Oct 3;60(10):1619. doi: 10.3390/medicina60101619. ABSTRACT Psoriasis is a common chronic inflammatory skin disease, associated with significant morbidity and a considerable negative impact on the patients' quality of life. The complex pathogenesis of psoriasis is still incompletely understood. Genetic predisposition, environmental factors like smoking, alcohol consumption, psychological stress, consumption of certain drugs, and mechanical trauma, as well as specific immun

Life (Basel). 2024 Oct 17;14(10):1318. doi: 10.3390/life14101318. ABSTRACT (1) Introduction: Topical dithranol is still commonly used today as an effective treatment for psoriasis. Dithranol treatment is often supplemented with balneotherapy, which has been shown to increase effectiveness and reduce side effects. The inorganic salts (sulfhide, selenium, zinc) are usually thought to be responsible for the effect. The antioxidant effect of the waters is thought to be behind the therapeutic effect,

Cureus. 2024 Mar 8;16(3):e55773. doi: 10.7759/cureus.55773. eCollection 2024 Mar. ABSTRACT Psoriasis is a chronic autoimmune inflammatory skin disease that is associated with other conditions, one of them being psoriatic arthritis (PsA). Apremilast, a phosphodiesterase-4 inhibitor, displayed promising results in multiple trials for patients with PsA. This systematic review and meta-analysis aims to showcase its efficacy and safety when compared to placebo. Preferred Reporting Items for Systemati

Cureus. 2024 Mar 8;16(3):e55773. doi: 10.7759/cureus.55773. eCollection 2024 Mar. ABSTRACT Psoriasis is a chronic autoimmune inflammatory skin disease that is associated with other conditions, one of them being psoriatic arthritis (PsA). Apremilast, a phosphodiesterase-4 inhibitor, displayed promising results in multiple trials for patients with PsA. This systematic review and meta-analysis aims to showcase its efficacy and safety when compared to placebo. Preferred Reporting Items for Systemati

Gut Microbes. 2025 Dec;17(1):2473524. doi: 10.1080/19490976.2025.2473524. Epub 2025 Mar 6. ABSTRACT This review explores the emerging term "gut-skin axis" (GSA), describing the bidirectional signaling that occurs between the skin and the gastrointestinal tract under both homeostatic and disease conditions. Central to GSA communication are the gut and skin microbiota, the microbial communities that colonize these barrier surfaces. By influencing diverse host pathways, including innate immune, vit

Cancers (Basel). 2024 Dec 27;17(1):55. doi: 10.3390/cancers17010055. ABSTRACT IL-23R (interleukin-23 receptor), found on the surface of several immune cells, plays a key role in the immune system. Indeed, this process is not limited to the inflammatory response but also plays a role in the adaptive immune response. The binding between IL-23R and its specific ligand, the interleukin 23, initiates a number of specific signals by modulating both properties and behavior of immune cells. In particula

J Dermatol. 2025 Feb 3. doi: 10.1111/1346-8138.17645. Online ahead of print. ABSTRACT The association between psoriasis and streptococcal infection has been widely explored in both children and adults. However, the exact impact of Streptococcus pharyngeal infection on the course of psoriasis is not fully comprehended. This study explored the impact of Streptococcus pharyngeal infection on psoriasis and investigated the effectiveness of systemic antibiotic therapy in conjunction with standard top

Arch Dermatol Res. 2025 Jan 16;317(1):268. doi: 10.1007/s00403-025-03805-y. ABSTRACT The relationship between psoriasis and osteopenia remains undetermined. Patients with psoriasis tend to have a higher Body Mass Index (BMI) compared to those without the condition. While it appears plausible that BMI could mediate this association, further study is required to confirm this hypothesis. The objective of this study is to ascertain whether BMI plays a role in influencing the impact of psoriasis on o

J Clin Med. 2024 Apr 22;13(8):2441. doi: 10.3390/jcm13082441. ABSTRACT Background: The care of psoriatic patients requires a multidisciplinary approach that addresses not only skin involvement but also cardiovascular risk factors. Coordination between dermatology and internal medicine departments, with a specific focus on treatment and long-term follow-up, can substantially improve the course of a disease and its associated complications. Objective: to evaluate the effects of the holistic manage

Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct 4. doi: 10.1007/s00210-024-03461-5. Online ahead of print. ABSTRACT Berberine (BBR), a Rhizoma Coptis-sourced isoquinoline alkaloid, is an effective drug for psoriasis treatment with its therapeutic mechanism remaining unclear. We delved into the mechanism of BBR affecting psoriatic skin inflammation by regulating keratinocyte pyroptosis. A psoriasis-like skin inflammation mouse model was induced by imiquimod (IMQ) and treated with BBR and a p38 acti

iScience. 2024 Sep 16;27(10):110984. doi: 10.1016/j.isci.2024.110984. eCollection 2024 Oct 18. ABSTRACT Mast cells (MCs) are tissue-resident immune cells known to degranulate in response to FcεRI crosslinking or MRGPRX2 engagement. MCs are found close to nerves, but the mechanisms that regulate this privileged localization remain unclear. Here, we investigated MRGPRX2 expression patterns and specific activities in MCs. We show that MRGPRX2 expression is heterogeneous in human MC (hMC) progenitor

Cutis. 2024 Feb;113(2):68-96. doi: 10.12788/cutis.0946. NO ABSTRACT PMID:38593099 | DOI:10.12788/cutis.0946 Den ganzen Artikel lesen

J Invest Dermatol. 2025 Jan 13:S0022-202X(24)03034-3. doi: 10.1016/j.jid.2024.09.025. Online ahead of print. ABSTRACT Inflammaging has long been linked to the pathogenesis of various aging-associated disorders, including cardiovascular disease, obesity, type 2 diabetes, and dementia. Yet, the origins of inflammaging remain unclear. Although inflammatory dermatoses such as psoriasis and atopic dermatitis predispose to the development of certain aging-associated disorders, suggesting a pathogenic

Arch Dermatol Res. 2024 Oct 5;316(9):659. doi: 10.1007/s00403-024-03405-2. ABSTRACT Vitiligo is a chronic autoimmune disorder characterized by progressive skin depigmentation. Vitiligo significantly impacts patients' quality of life, contributing to psychological and social burdens. Despite readily available therapeutic options, many cases remain refractory to treatment, highlighting the critical need for safer and more effective therapies. Currently, ruxolitinib is the only FDA-approved medicat

Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831. ABSTRACT Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histo

J Cosmet Dermatol. 2025 Jan;24(1):e16761. doi: 10.1111/jocd.16761. ABSTRACT BACKGROUND: Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option. AIMS: Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive. In addit

Int J Mol Sci. 2024 Dec 30;26(1):246. doi: 10.3390/ijms26010246. ABSTRACT Lipids are intimately associated with skin condition. This review aims to discuss the function of linoleic acid (LA, 18:2, ω-6), an essential fatty acid, in skin health and hair growth. In skin, LA can be metabolized into ω-6 unsaturated fatty acid, oxidized derivatives and incorporated into complex lipid molecules, including ω-hydroxy-ceramides. Previous research has revealed that skin diseases including acne, atopic derm

Cureus. 2025 Jan 3;17(1):e76869. doi: 10.7759/cureus.76869. eCollection 2025 Jan. ABSTRACT While topical steroids are an invaluable tool used for the treatment of pruritic rashes, they can also complicate attempts at a definitive diagnosis. The temporal association between steroid use and biopsy must be taken into account when investigating the underlying etiology of such rashes. In patients with a history of dermatologic disease with the onset of a new rash, management should include a biopsy,

Asian J Surg. 2024 Apr 10:S1015-9584(24)00605-5. doi: 10.1016/j.asjsur.2024.03.178. Online ahead of print. NO ABSTRACT PMID:38604866 | DOI:10.1016/j.asjsur.2024.03.178 Den ganzen Artikel lesen

Genes (Basel). 2024 Mar 22;15(4):393. doi: 10.3390/genes15040393. ABSTRACT Autoimmunity is defined as the inability to regulate immunological activities in the body, especially in response to external triggers, leading to the attack of the tissues and organs of the host. Outcomes include the onset of autoimmune diseases whose effects are primarily due to dysregulated immune responses. In past years, there have been cases that show an increased susceptibility to other autoimmune disorders in pati

J Am Acad Dermatol. 2024 Oct 9:S0190-9622(24)02990-6. doi: 10.1016/j.jaad.2024.10.006. Online ahead of print. NO ABSTRACT PMID:39393547 | DOI:10.1016/j.jaad.2024.10.006 Den ganzen Artikel lesen

J Am Acad Dermatol. 2025 Jan 8:S0190-9622(25)00033-7. doi: 10.1016/j.jaad.2025.01.005. Online ahead of print. NO ABSTRACT PMID:39793709 | DOI:10.1016/j.jaad.2025.01.005 Den ganzen Artikel lesen