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Balkan Med J. 2024 May 3;41(3):174-185. doi: 10.4274/balkanmedj.galenos.2024.2024-1-96. ABSTRACT BACKGROUND: Psoriasis is a chronic inflammatory skin disease that has no cure. While the specific cause of psoriasis is unknown, interactions between immune cells and inflammatory cytokines are believed to be important in its pathogenesis. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells that profoundly affects dendritic cells (DCs) and is involved in allergy and inflamm

J Clin Med. 2025 Jan 2;14(1):223. doi: 10.3390/jcm14010223. ABSTRACT Background/Objectives: Psoriasis is a chronic inflammatory skin disease that may have a significant impact on patients' quality of life. Alongside clinical scores, treatment goals include improvements in patients' quality of life, divided into its social, working and psychosocial life aspects. Indeed, psychological impairment should always be considered in the management of moderate-to-severe psoriasis. Tildrakizumab, an anti-I

Psoriasis (Auckl). 2024 Sep 23;14:103-114. doi: 10.2147/PTT.S484609. eCollection 2024. ABSTRACT PURPOSE Tobacco smoking and alcohol drinking are positively associated with psoriasis prevalence and disease severity. Researches focusing on the influence of smoking and drinking on the treatment efficacy of psoriasis are still limited, especially their interaction effect. This study aims to explore the interactive effects of smoking and drinking on the treatment efficacy in psoriasis patients. PATIE

Tob Induc Dis. 2024 Apr 11;22. doi: 10.18332/tid/184143. eCollection 2024. ABSTRACT INTRODUCTION: Smoking is an independent and modifiable risk factor for the onset and development of psoriasis; however, evidence on the association between tobacco smoking and psoriasis treatment efficacy is limited. This study aimed to explore the influence of smoking on treatment efficacy in a cohort of patients with psoriasis in Shanghai, China. METHODS: Patients with psoriasis were recruited from the Shanghai

J Dermatol Sci. 2024 Jun 18:S0923-1811(24)00132-4. doi: 10.1016/j.jdermsci.2024.06.002. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is an inflammatory skin disease with unclear pathogenesis and unmet therapeutic needs. OBJECTIVE: To investigate the role of senescent CD4+ T cells in psoriatic lesion formation and explore the application of senolytics in treating psoriasis. METHODS: We explored the expression levels of p16INK4a and p21, classical markers of cellular senescence, in CD4+ T

J Trace Elem Med Biol. 2024 Dec 10;87:127580. doi: 10.1016/j.jtemb.2024.127580. Online ahead of print. ABSTRACT BACKGROUND: Trichophyton rubrum is a widespread human pathogenic fungus, colonizing keratinized tissue of outer body-parts. Thereby, the pathogen is relying on nutrients available from the host. The invasive mechanism of the pathogen is relaying on secreted proteases, which hydrolyze skin-proteins for subsequent up-take. METHODS: In this study, we analyzed the gene expression of secret

Australas J Dermatol. 2024 Oct 12. doi: 10.1111/ajd.14368. Online ahead of print. NO ABSTRACT PMID:39394861 | DOI:10.1111/ajd.14368 Den ganzen Artikel lesen

Medicina (Kaunas). 2024 Mar 31;60(4):579. doi: 10.3390/medicina60040579. ABSTRACT Background and Objectives: Tuberculosis is caused by Mycobacterium tuberculosis (MTB), while nontuberculous mycobacteria (NTM) encompass a group of mycobacterial species that are distinct from the MTB complex and leprae. Spondyloarthritis (SpA) is a group of chronic inflammatory diseases with shared clinical characteristics and is treated with biological agents; however, their use may elevate the risk of MTB and NT

Tunis Med. 2025 Jan 5;103(1):32-43. doi: 10.62438/tunismed.v103i1.5565. ABSTRACT AIM: To develop good practice recommendations (GPR) for the therapeutic management of patients with spondyloarthritis (SpA), including psoriatic arthritis. METHODS: Following standardised procedures, a systematic review of the literature was carried out on non-pharmacological and non-biological pharmacological treatments for SpA. The review was based on questions defined by a working group of 15 rheumatologists. The

JAAD Case Rep. 2024 Sep 12;53:93-96. doi: 10.1016/j.jdcr.2024.08.030. eCollection 2024 Nov. NO ABSTRACT PMID:39823053 | PMC:PMC11736064 | DOI:10.1016/j.jdcr.2024.08.030 Den ganzen Artikel lesen

Appl Opt. 2024 May 20;63(15):4131-4143. doi: 10.1364/AO.520397. ABSTRACT Planar X e B r ∗ and X e C l ∗ excilamps emitting noncoherent narrowband UVB light (280-315 nm) are now widely used to cure psoriasis and vitiligo as well as to improve vitamin D synthesis. The two-dimensional integral formula has been deducted in this study, which is a good method and has great practical significance to calculate the total radiant power and assess the energy efficiency of a planar UV lamp. The measured rad

Autoimmun Rev. 2024 Sep 28:103649. doi: 10.1016/j.autrev.2024.103649. Online ahead of print. ABSTRACT Tyk2 is a member of the JAK kinase family. It is an important mediator in pro-inflammatory signalling, implicated in both innate and adaptive immune system. Activation of Tyk2 is believed to be integral to cellular processes that contribute to the development and progression of autoimmune disorders. Selective targeting of Tyk2 may reduce the number of adverse events as compared to non-selective

Adv Rheumatol. 2024 Apr 11;64(1):25. doi: 10.1186/s42358-024-00367-x. ABSTRACT BACKGROUND: Nail involvement is frequent in patients with psoriasis (Pso) and psoriatic arthritis (PsA) and there is a relationship between nail involvement and inflammation of the enthesis. The main objective of the present study is to describe the ultrasound findings and clinical characteristics of nails from patients with psoriasis and psoriatic arthritis with and without nail dystrophy. METHODS: A cross-sectional

Front Med Technol. 2024 Mar 25;6:1200400. doi: 10.3389/fmedt.2024.1200400. eCollection 2024. ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory follicular skin condition that is associated with significant psychosocial and economic burden and a diminished quality of life and work productivity. Accurate diagnosis of HS is challenging due to its unknown etiology, which can lead to underdiagnosis or misdiagnosis that results in increased patient and healthcare system burden. We applie

Curr Med Res Opin. 2024 Apr 10:1-13. doi: 10.1080/03007995.2024.2340720. Online ahead of print. ABSTRACT OBJECTIVE: Effective health communication is critical for understanding and acting on health information. This cross-sectional study explored participants' understanding of their health condition, their preferences for receiving health communications, and their interest in receiving clinical trial results across several therapeutic areas. METHODS: The study recruited participants via social m

Arch Dermatol Res. 2024 Oct 26;316(10):717. doi: 10.1007/s00403-024-03465-4. ABSTRACT It has been reported that many people with psoriasis have been diagnosed with secondary IgA nephropathy (IgAN). However, the mechanisms behind the association between psoriasis and IgAN have not been well clarified. The connection between psoriasis and IgAN deserves deeper exploration. Mendelian randomization (MR) analysis would be employed to explore the link of causality between IgAN and psoriasis, psoriasis

Biomedicines. 2024 Mar 25;12(4):732. doi: 10.3390/biomedicines12040732. ABSTRACT Psoriasis, a prevalent inflammatory skin disorder affecting a significant percentage of the global population, poses challenges in its management, necessitating the exploration of novel cost-effective and widely accessible therapeutic options. This study investigates the potential of ursolic acid (UA), a triterpenoid known for its anti-inflammatory and pro-apoptotic properties, in addressing psoriasis-related inflam

Postepy Biochem. 2024 Sep 17;70(3):307-314. doi: 10.18388/pb.2021_554. Print 2024 Sep 30. ABSTRACT Vitamin C is one of the most important and necessary nutrient for human health, which has great potential as cosmeceutic, which protects health and the skin good condition. Thru the collagen biosynthesis stimulation it affects to the physiology of human skin, participating in the hydroxylation process of proline and lysine, and participates in tissue reconstruction while wound healing. Deficiency o

J Clin Aesthet Dermatol. 2024 Dec;17(11):45-49. ABSTRACT BACKGROUND: Dimethyl fumarate (DMF) is an oral treatment approved by the European Medicines Agency (EMA) to treat moderate-to-severe plaque psoriasis among adult patients. OBJECTIVES: This study aims to evaluate sociodemographic, anthropometric, and medical characteristics in patients with psoriasis without previous history of traditional systemic therapy and to observe if the efficacy or AEs of dimethyl fumarate correlate to any of the pa

Int J Mol Sci. 2024 Mar 29;25(7):3823. doi: 10.3390/ijms25073823. ABSTRACT Trace elements are essential for maintaining the body's homeostasis, and their special role has been demonstrated in skin physiology. Among the most important trace elements are zinc, copper, and iron. A deficiency or excess of trace elements can be associated with an increased risk of skin diseases, so increasing their supplementation or limiting intake can be helpful in dermatological treatment. In addition, determinati