Aus Pubmed

J Clin Periodontol. 2024 May 3. doi: 10.1111/jcpe.13996. Online ahead of print. ABSTRACT AIM: To investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature- and imiquimod-induced diseases on murine models. MATERIALS AND METHODS: Thirty-two C57/BL6J mice were randomly allocated to four experimental groups: control (P- Pso-), ligature-induced periodontitis (P+ Pso-), imiquimod-induced psoriasis (P- Pso+) and periodontitis and p

Life (Basel). 2024 Apr 16;14(4):516. doi: 10.3390/life14040516. ABSTRACT Immuno-correlated dermatological pathologies refer to skin disorders that are closely associated with immune system dysfunction or abnormal immune responses. Advancements in the field of artificial intelligence (AI) have shown promise in enhancing the diagnosis, management, and assessment of immuno-correlated dermatological pathologies. This intersection of dermatology and immunology plays a pivotal role in comprehending an

Indian J Dermatol Venereol Leprol. 2024 Mar 19:1-7. doi: 10.25259/IJDVL_631_2023. Online ahead of print. ABSTRACT Background Chronic childhood diseases are a burden for paediatric patients and their caregivers. Limited data are available on the effect of paediatric psoriasis on the caregiver's well-being and quality of life. Objective To assess the impact of childhood and adolescent chronic plaque psoriasis on parents/caregivers quality of life. Methods A single-centre cross-sectional study was

Clin Rheumatol. 2025 Jan 14. doi: 10.1007/s10067-025-07306-1. Online ahead of print. ABSTRACT OBJECTIVE: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disease associated with other chronic inflammatory diseases such as familial Mediterranean fever (FMF), juvenile idiopathic arthritis (JIA), spondylarthropathies, inflammatory bowel disease (IBD), and pyoderma gangrenosum. We aimed to describe the clinical and follow-up characteristics of patients with CNO and to compar

Arch Dermatol Res. 2024 May 18;316(5):181. doi: 10.1007/s00403-024-02978-2. ABSTRACT Background An increasing body of observational studies has indicated a potential link between allergic diseases, namely atopic dermatitis (AD), allergic rhinitis (AR), allergic asthma (AA), and psoriasis (PSO) as well as psoriatic arthritis (PSA). However, the presence and causal direction of this association remain uncertain. Methods We conducted two-sample Mendelian randomization (TSMR) analyses utilizing summ

J Inflamm Res. 2024 May 28;17:3433-3448. doi: 10.2147/JIR.S467099. eCollection 2024. ABSTRACT As one of the most prevalent chronic inflammatory skin diseases, atopic dermatitis (AD) increasingly affects the aging population. Amid the ongoing global aging trend, it's essential to recognize the intricate relationship between AD and aging. This paper reviews existing knowledge, summarizing clinical observations of associations between AD and aging-related diseases in various systems, including endo

Lipids Health Dis. 2024 May 17;23(1):143. doi: 10.1186/s12944-024-02123-y. ABSTRACT BACKGROUND: Lipid accumulation product (LAP) is an accessible and relatively comprehensive assessment of obesity that represents both anatomical and physiological lipid accumulation. Obesity and psoriasis are potentially related, according to previous research. Investigating the relationship between adult psoriasis and the LAP index was the goal of this study. METHODS: This is a cross-sectional study based on dat

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17481. Online ahead of print. NO ABSTRACT PMID:39349351 | DOI:10.1111/1346-8138.17481 Den ganzen Artikel lesen

Arch Dermatol Res. 2025 Jan 16;317(1):254. doi: 10.1007/s00403-025-03809-8. NO ABSTRACT PMID:39821329 | DOI:10.1007/s00403-025-03809-8 Den ganzen Artikel lesen

J Clin Med. 2024 Dec 27;14(1):91. doi: 10.3390/jcm14010091. ABSTRACT Background/Objectives: Psoriasis is a chronic inflammatory disease that significantly impacts physical and emotional health. Statins, primarily used as lipid-lowering drugs, have also demonstrated anti-inflammatory effects. While some studies suggest that statins may improve psoriasis symptoms, the findings have been inconsistent. This study aims to investigate the association between prior statin use and the onset of psoriasis

Med J Malaysia. 2025 Jan;80(1):25-30. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin condition often associated with comorbidities that may impact cognitive function. This study aims to determine if psoriasis is associated with the risk of cognitive impairment and to assess the relationship between cognitive impairment and various disease-related factors, including psoriasis severity, disease duration, and the presence of psoriatic arthropathy, using the Virtual Cognitive Assess

Int J Surg. 2024 May 3. doi: 10.1097/JS9.0000000000001514. Online ahead of print. ABSTRACT BACKGROUND: Glucagon-like peptide-1 receptor (GLP1R) agonists have been approved by Food and Drug Administration for management of obesity. However, the causal relationship of GLP1R agonists (GLP1RA) with cancers still unclear. METHODS: The available cis-eQTLs for drugs target genes (GLP1R) were used as proxies for exposure to GLP1RA. Mendelian randomizations (MR) were performed to reveal the association o

J Dermatol. 2024 Jun 7. doi: 10.1111/1346-8138.17313. Online ahead of print. ABSTRACT Nail psoriasis is a chronic condition characterized by nail dystrophy affecting the nail matrix and bed. The severity of nail psoriasis is commonly assessed using the Nail Psoriasis Severity Index (NAPSI), which evaluates the characteristics and extent of nail involvement. Although the NAPSI is numeric, reproducible, and simple, the assessment process is time-consuming and often challenging to use in real-world

Drug Des Devel Ther. 2024 Aug 28;18:3871-3889. doi: 10.2147/DDDT.S467066. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory disease. Qingre Lishi Decoction (QRLSD) has achieved great clinical effect in the treatment of psoriasis. However, the potential bioactive components and the mechanisms are yet unclear. AIM: To analyze the serum parameters of rats fed with QRLSD, screen out the active components of QRLSD, and explore the potential targets and pathwa

J Eur Acad Dermatol Venereol. 2024 Oct 12. doi: 10.1111/jdv.20367. Online ahead of print. ABSTRACT Targeted biologic drugs and small molecules have transformed the psoriasis treatment landscape in recent years. The Belgian healthcare system, in common with many others across Europe, must balance the burgeoning use of these transformative, yet expensive, drugs with the sustainable use of limited resources. Drawing on recent updates to the EuroGuiDerm and the German S2 psoriasis guidelines, eight

J Am Acad Dermatol. 2024 Apr 6:S0190-9622(24)00568-1. doi: 10.1016/j.jaad.2024.03.041. Online ahead of print. ABSTRACT BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferas

J Am Acad Dermatol. 2024 Apr 6:S0190-9622(24)00568-1. doi: 10.1016/j.jaad.2024.03.041. Online ahead of print. ABSTRACT BACKGROUND: Patients with psoriasis are at increased risk of liver function abnormalities. OBJECTIVE: Explore rates of hepatic treatment-emergent adverse events (TEAEs) and changes in liver parameters in bimekizumab-treated patients with psoriasis. METHODS: Data are reported from five phase 3/3b trials over 2 years. Hepatic TEAEs, laboratory elevations in alanine aminotransferas

Int J Dermatol. 2025 Jan 16. doi: 10.1111/ijd.17658. Online ahead of print. NO ABSTRACT PMID:39821776 | DOI:10.1111/ijd.17658 Den ganzen Artikel lesen

Arch Dermatol Res. 2024 Dec 14;317(1):118. doi: 10.1007/s00403-024-03617-6. ABSTRACT Ulcerative colitis (UC) and psoriasis are highly correlated clinically; however, it is unclear whether they have a common pathophysiological mechanism. The purpose of this study is to investigate the important molecules and pathways that mediate the coexistence of UC and psoriasis through quantitative bioinformatics analysis of public RNA-sequencing databases. The UC (GSE38713) and psoriasis (GSE30999) datasets

J Clin Med. 2024 Mar 27;13(7):1940. doi: 10.3390/jcm13071940. ABSTRACT Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evid

Int J Mol Sci. 2024 Dec 30;26(1):261. doi: 10.3390/ijms26010261. ABSTRACT Blood-based extracellular matrix (ECM) fragments have been identified as potential pharmacologic biomarkers in spondyloarthritis and diagnostic biomarkers in psoriatic arthritis and psoriasis vulgaris. This study aimed to explore whether ECM fragments can differentiate patients with psoriasis from healthy controls (HC) and determine their potential as biomarkers for response to treatment in psoriasis. The study population

Ital J Dermatol Venerol. 2024 Dec;159(6):663-675. doi: 10.23736/S2784-8671.24.08083-6. ABSTRACT The introduction of systemic biologic therapies marked a significant advancement in the treatment of moderate to severe psoriasis. However, the high cost associated with these treatments has considerably restricted their widespread utilization. The expiration of biologic patents has allowed the development of biosimilars - medications that are highly similar to approved biologics. Biosimilars hold the

Clin Dermatol. 2025 Jan 3:S0738-081X(25)00001-X. doi: 10.1016/j.clindermatol.2025.01.001. Online ahead of print. ABSTRACT There is a significant amount of research examining the link between psoriasis and common mental health disorders; however, studies on less common psychiatric disorders, such as bipolar disorder (BD), remain limited. We conducted a systematic review of studies in the PubMed and Cochrane databases that explored the relationship between BD and psoriasis. Additionally, we evalua

Dermatol Ther (Heidelb). 2024 May 9. doi: 10.1007/s13555-024-01162-8. Online ahead of print. ABSTRACT INTRODUCTION: Brodalumab is a human interleukin-17 receptor A antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies. Although the US prescribing information for brodalumab includes a boxed warning regarding suicidal ideatio

J Rheumatol. 2024 Jun 7:jrheum.2024-0330. doi: 10.3899/jrheum.2024-0330. Online ahead of print. ABSTRACT The 78th Annual Meeting of the Canadian Rheumatology Association was held at the RBC Convention Centre in Winnipeg, Manitoba, Canada, and virtually on February 28-March 2, 2024. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2024 Award Winners: Distinguished Rheumatologist, John M. Esdaile; Dis