Aus Pubmed

Acta Pharm Sin B. 2024 Dec;14(12):5161-5180. doi: 10.1016/j.apsb.2024.08.013. Epub 2024 Aug 22. ABSTRACT Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding a viable resolution to the formidable barriers presented by the cutaneous interface. This review examines MNs as an advanced approach to enhancing dermatological pathology management. It explores the complex dermis structure and highlights the limitations of traditional transdermal methods, emphasizin

World Allergy Organ J. 2024 Dec 19;18(1):101014. doi: 10.1016/j.waojou.2024.101014. eCollection 2025 Jan. ABSTRACT BACKGROUND: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. METHODS: This study conducted a phenome-wide association study (PheWAS) using known AR risk

J Autoimmun. 2025 Jan 11;151:103357. doi: 10.1016/j.jaut.2025.103357. Online ahead of print. ABSTRACT Regulatory T cell (Treg) play a pivotal role in immune regulation and maintaining host immune homeostasis. Treg heterogeneity, characterized by diverse gene expression profiles and functional states, is complex in both health and disease. Research reveals that Tregs are not a uniform population but exhibit diversity based on their origin, location, and functional status. This heterogeneity is cr

Arch Dermatol Res. 2025 Jan 13;317(1):237. doi: 10.1007/s00403-024-03701-x. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disorder affecting millions worldwide. Dermoscopy and proximal nailfold capillaroscopy have emerged as valuable tools for understanding the pathophysiology and treatment response of psoriasis lesions. OBJECTIVES: This study aimed to contribute to the limited literature on using dermoscopic findings to detect treatment effectiveness in patients with psoriasis

J Invest Dermatol. 2025 Jan 8:S0022-202X(24)03024-0. doi: 10.1016/j.jid.2024.11.007. Online ahead of print. ABSTRACT Melanoma is a devastating form of skin cancer characterized by a high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy and targeted therapies have significantly revolutionized melanoma treatment, the majority of patients fail to achieve durable responses, highlighting the urgent need for novel therapeutic strategies. Ferroptosis, an iron-d

J Dermatol. 2025 Jan 11. doi: 10.1111/1346-8138.17623. Online ahead of print. NO ABSTRACT PMID:39797588 | DOI:10.1111/1346-8138.17623 Den ganzen Artikel lesen

J Cosmet Dermatol. 2025 Jan;24(1):e16761. doi: 10.1111/jocd.16761. ABSTRACT BACKGROUND: Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option. AIMS: Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive. In addit

J Clin Med. 2025 Jan 2;14(1):223. doi: 10.3390/jcm14010223. ABSTRACT Background/Objectives: Psoriasis is a chronic inflammatory skin disease that may have a significant impact on patients' quality of life. Alongside clinical scores, treatment goals include improvements in patients' quality of life, divided into its social, working and psychosocial life aspects. Indeed, psychological impairment should always be considered in the management of moderate-to-severe psoriasis. Tildrakizumab, an anti-I

J Clin Med. 2024 Dec 27;14(1):91. doi: 10.3390/jcm14010091. ABSTRACT Background/Objectives: Psoriasis is a chronic inflammatory disease that significantly impacts physical and emotional health. Statins, primarily used as lipid-lowering drugs, have also demonstrated anti-inflammatory effects. While some studies suggest that statins may improve psoriasis symptoms, the findings have been inconsistent. This study aims to investigate the association between prior statin use and the onset of psoriasis

Cancers (Basel). 2024 Dec 27;17(1):55. doi: 10.3390/cancers17010055. ABSTRACT IL-23R (interleukin-23 receptor), found on the surface of several immune cells, plays a key role in the immune system. Indeed, this process is not limited to the inflammatory response but also plays a role in the adaptive immune response. The binding between IL-23R and its specific ligand, the interleukin 23, initiates a number of specific signals by modulating both properties and behavior of immune cells. In particula

Int J Mol Sci. 2025 Jan 4;26(1):394. doi: 10.3390/ijms26010394. ABSTRACT Inflammatory skin diseases comprise a group of skin conditions characterized by damage to skin function due to overactive immune responses. These disorders not only impair the barrier function of the skin but also deteriorate the quality of life and increase the risk of psychiatric issues. Here, a low-modulus phosphatidylserine-exposing microvesicle (deformed PSV, D-PSV) was produced, characterized, and evaluated for its po

Int J Mol Sci. 2024 Dec 30;26(1):261. doi: 10.3390/ijms26010261. ABSTRACT Blood-based extracellular matrix (ECM) fragments have been identified as potential pharmacologic biomarkers in spondyloarthritis and diagnostic biomarkers in psoriatic arthritis and psoriasis vulgaris. This study aimed to explore whether ECM fragments can differentiate patients with psoriasis from healthy controls (HC) and determine their potential as biomarkers for response to treatment in psoriasis. The study population

Int J Mol Sci. 2024 Dec 30;26(1):246. doi: 10.3390/ijms26010246. ABSTRACT Lipids are intimately associated with skin condition. This review aims to discuss the function of linoleic acid (LA, 18:2, ω-6), an essential fatty acid, in skin health and hair growth. In skin, LA can be metabolized into ω-6 unsaturated fatty acid, oxidized derivatives and incorporated into complex lipid molecules, including ω-hydroxy-ceramides. Previous research has revealed that skin diseases including acne, atopic derm

Int J Mol Sci. 2024 Dec 28;26(1):179. doi: 10.3390/ijms26010179. ABSTRACT Growing scientific evidence suggests a strong interconnection between inflammatory skin diseases and osteoporosis (OP), a systemic condition characterized by decreased bone density and structural fragility. These conditions seem to share common pathophysiological mechanisms, including immune dysregulation, chronic inflammation, and vitamin D deficiency, which play a crucial role in both skin and bone health. Additionally,

Diagnostics (Basel). 2024 Dec 28;15(1):55. doi: 10.3390/diagnostics15010055. ABSTRACT Background: Psoriasis is a chronic, immune-mediated skin disease characterized by lifelong persistence and fluctuating symptoms. The clinical similarities among its subtypes and the diversity of symptoms present challenges in diagnosis. Early diagnosis plays a vital role in preventing the spread of lesions and improving patients' quality of life. Methods: This study proposes a hybrid model combining multiple tr

An Bras Dermatol. 2025 Jan 9:S0365-0596(24)00252-6. doi: 10.1016/j.abd.2024.05.005. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies. OBJECTIVES: In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week treatment period. METHODS: A double-center retrospective cohort study was conducted, enrolling

Biochem Pharmacol. 2025 Jan 8:116745. doi: 10.1016/j.bcp.2025.116745. Online ahead of print. ABSTRACT The pathogenesis of psoriasis involves hyperproliferation of epidermal keratinocytes and abnormal interactions between activated keratinocytes and infiltrating immune cells. Emerging evidence has shown that keratinocytes play essential roles in both the initiation and maintenance of psoriasis, suggesting that exposing keratinocytes to agents with antiproliferative and anti-inflammatory effects m

Diabetes Metab Syndr. 2025 Jan 7;19(1):103186. doi: 10.1016/j.dsx.2025.103186. Online ahead of print. ABSTRACT OBJECTIVE: To investigate the causal association of using glucagon-like peptide-1 receptor (GLP1R) agonists with autoimmune diseases. METHODS: The available cis-eQTLs for drugs target genes (GLP1R) were used as genetic variants for exposure to GLP1R agonists. Type 2 diabetes was used as positive control. Mendelian randomizations (MR) were performed to explore the association of genetica

J Am Acad Dermatol. 2025 Jan 8:S0190-9622(25)00033-7. doi: 10.1016/j.jaad.2025.01.005. Online ahead of print. NO ABSTRACT PMID:39793709 | DOI:10.1016/j.jaad.2025.01.005 Den ganzen Artikel lesen

RSC Med Chem. 2025 Jan 2. doi: 10.1039/d4md00781f. Online ahead of print. ABSTRACT Topical delivery of therapeutics on the skin can effectively alleviate skin symptoms of psoriasis and reduce systemic toxicity. However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact. Here, we reported an oligopeptide hydrogel that encapsulates cell-penetrating-peptide (CPP)-decorated curcumin-loaded nanoemulsions (Cur-CNEs) to enhance the skin penetration of curcu

Cureus. 2024 Dec 4;16(12):e75105. doi: 10.7759/cureus.75105. eCollection 2024 Dec. ABSTRACT Erythrodermic psoriasis (EP) is a rare and challenging-to-diagnose severe form of psoriasis. Its presentation can have similarities with other inflammatory skin conditions, complicating subsequent management. We present a case of a 76-year-old woman with EP who presented with fever, tachycardia, leg swelling with pain and redness, and reduced consciousness. Her imaging revealed characteristic features of

Psoriasis (Auckl). 2024 Dec 31;14:195-206. doi: 10.2147/PTT.S493315. eCollection 2024. ABSTRACT Psoriasis is a chronic inflammatory disease with a complex pathogenesis. Hyperplasia of glycolytic-dependent epidermal keratinocytes (KCs) is a new hallmark of psoriasis pathogenesis. Meanwhile, immune cells undergo metabolic reprogramming similar to KCs. Glycolysis provides energy for the proliferation of KCs, while it also releases lactic acid to facilitate the differentiation of immune cells. In tu

Acad Pathol. 2024 Dec 11;12(1):100154. doi: 10.1016/j.acpath.2024.100154. eCollection 2025 Jan-Mar. NO ABSTRACT PMID:39758588 | PMC:PMC11697160 | DOI:10.1016/j.acpath.2024.100154 Den ganzen Artikel lesen

J Clin Aesthet Dermatol. 2024 Dec;17(11):45-49. ABSTRACT BACKGROUND: Dimethyl fumarate (DMF) is an oral treatment approved by the European Medicines Agency (EMA) to treat moderate-to-severe plaque psoriasis among adult patients. OBJECTIVES: This study aims to evaluate sociodemographic, anthropometric, and medical characteristics in patients with psoriasis without previous history of traditional systemic therapy and to observe if the efficacy or AEs of dimethyl fumarate correlate to any of the pa

J Clin Aesthet Dermatol. 2024 Dec;17(11):32-33. ABSTRACT We present a case of a patient with longstanding psoriasis vulgaris who developed an atopic dermatitis-like eruption following long-term IL-17A inhibitor therapy. Following many years of excellent disease control with secukinumab and later ixekizumab, he developed a de novo eczematous eruption, which showed spongiotic dermatitis upon biopsy. The patient was successfully treated for both psoriasis and atopic dermatitis with upadacitinib, a