Aus Pubmed

Front Immunol. 2024 Oct 7;15:1435141. doi: 10.3389/fimmu.2024.1435141. eCollection 2024. ABSTRACT Recent studies have shown that local injection of secukinumab can achieve positive therapeutic effects when applied in the treatment of nail psoriasis. At present, there have been no other studies on the use of biological agents in the treatment of pediatric nail psoriasis. Three children were included in the study to evaluate the efficacy and safety of periungual injection and long-term injection o

Front Public Health. 2024 Mar 28;12:1333811. doi: 10.3389/fpubh.2024.1333811. eCollection 2024. ABSTRACT BACKGROUND: In recent years, an increasing number of observational studies have reported the impact of air pollution on autoimmune diseases (ADs). However, no Mendelian randomization (MR) studies have been conducted to investigate the causal relationships. To enhance our understanding of causality, we examined the causal relationships between particulate matter (PM) and nitrogen oxides (NOx)

Arch Dermatol Res. 2024 Jun 8;316(7):369. doi: 10.1007/s00403-024-03074-1. NO ABSTRACT PMID:38850288 | DOI:10.1007/s00403-024-03074-1 Den ganzen Artikel lesen

Clin Exp Dermatol. 2024 May 3:llae152. doi: 10.1093/ced/llae152. Online ahead of print. ABSTRACT BACKGROUND: Dysregulated interleukin (IL)-17/IL-23 signaling contributes to psoriasis pathogenesis. Cedirogant is an inverse agonist of retinoic acid-related orphan receptor gamma thymus (RORγt), a key transcription factor responsible for IL-17 synthesis and a regulator of the T helper 17 cell lineage program. OBJECTIVE: To evaluate the efficacy and safety of cedirogant to treat moderate-to-severe ps

RMD Open. 2024 Oct 22;10(4):e004457. doi: 10.1136/rmdopen-2024-004457. ABSTRACT OBJECTIVE: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Adding to studies focused on the role of T cells and macrophages, we sought to investigate the systemic activation of leukocytes in PsA. METHODS: We assessed the activation state of leukocyte populations, including polymorphonuclear neutrophils (PMNs) and monocyte/macrophages, in blood and synovial fluid (SF) by multicolour f

Pharmaceuticals (Basel). 2024 Oct 16;17(10):1376. doi: 10.3390/ph17101376. ABSTRACT Background/Objectives: This study investigates the chemical composition, antioxidant, antibacterial, and hemolytic properties of ylang-ylang (Cananga odorata) essential oil, with a focus on its potential therapeutic applications for dermatological diseases and the importance of transforming such bioactive properties into a stable, safe, and effective formulation. Methods/Rsults: Essential oils were extracted from

Rheumatol Adv Pract. 2024 Apr 10;8(2):rkae052. doi: 10.1093/rap/rkae052. eCollection 2024. NO ABSTRACT PMID:38698954 | PMC:PMC11065474 | DOI:10.1093/rap/rkae052 Den ganzen Artikel lesen

J Dermatol. 2024 Oct 22. doi: 10.1111/1346-8138.17450. Online ahead of print. ABSTRACT Psoriasis is a skin disease with a complicated pathophysiology that includes an extensive inflammatory cytokine network. Nevertheless, the relationship between psoriasis severity, cytokine levels, and coronary artery atherosclerosis remains poorly understood. Our aim was to find serum markers as potential candidates for cardiovascular disease (CVD) risk monitoring in patients with psoriasis. Therefore, we exam

J Immunol Res. 2024 Apr 1;2024:9927964. doi: 10.1155/2024/9927964. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, the cellular and molecular mechanisms underlying this progression remain unclear. METHODS: We performed high-dimensional, in-depth

Ter Arkh. 2024 Jun 3;96(5):479-485. doi: 10.26442/00403660.2024.05.202703. ABSTRACT AIM: To study and compare the clinical and imaging characteristics of psoriatic arthritis (PsA) in men and women. MATERIALS AND METHODS: The study included 956 PsA patients observed in the Russian register, 411 (43%) men and 545 (57%) women. The average age of men/women was 46.0±16.50/50.7±17.20 years (p<0.001), the duration of PsA was 9.9±6.4/10.3±7.6 years (p>0.05), the age at the time of PsA establishmen

Front Med (Lausanne). 2024 Aug 16;11:1455953. doi: 10.3389/fmed.2024.1455953. eCollection 2024. ABSTRACT INTRODUCTION: Psoriasis, a chronic inflammatory skin disease, is believed to be influenced by both genetic and environmental factors. Despite this understanding, the clinical epidemiological status of psoriasis patients with a family history of the disease remains uncertain. METHODS: In this study, we participated in a multicenter observational epidemiological study involved over 1,000 hospit

Cureus. 2024 May 9;16(5):e59969. doi: 10.7759/cureus.59969. eCollection 2024 May. ABSTRACT Background Psoriasis is a chronic inflammatory skin disease with multiple organ manifestations such as arthritis and cardiovascular diseases. While recent therapeutic advancements in systemic biologics have demonstrated efficacy against psoriasis, a complete cure has not been achieved and patients require lifelong treatment to control symptoms. Objective This study aimed to clarify the clinical characteris

Arch Dermatol Res. 2024 Oct 26;316(10):705. doi: 10.1007/s00403-024-03425-y. ABSTRACT To systematically evaluate clinical features and effects of cyclosporine in the treatment of psoriasis. Databases including Web of Science, PubMed, The Cochrane Library, Embase, CNKI, Wan Fang, and VIP were electronically searched for studies on the use of cyclosporine in the treatment of psoriasis, from inception to March 2024. Two reviewers independently screened the literature, extracted data, and assessed t

Nat Commun. 2024 May 9;15(1):3901. doi: 10.1038/s41467-024-48288-z. ABSTRACT Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pattern in the later stage of activation, and the mechanisms mediating the rapid termination of active NF-κB remain unclear. Here, we showed IκBα-independent rapid termination of nuclear NF-κB mediated by CLK2, which

Eur J Med Res. 2024 Oct 5;29(1):487. doi: 10.1186/s40001-024-02088-9. ABSTRACT Cold atmospheric plasma (CAP) technology has emerged as a revolutionary therapeutic technology in dermatology, recognized for its safety, effectiveness, and minimal side effects. CAP demonstrates substantial antimicrobial properties against bacteria, viruses, and fungi, promotes tissue proliferation and wound healing, and inhibits the growth and migration of tumor cells. This paper explores the versatile applications

Skin Res Technol. 2024 Oct;30(10):e70071. doi: 10.1111/srt.70071. ABSTRACT OBJECTIVES: Cold plasma has shown efficacy in various dermatological applications by reduces inflammatory responses and modulating cytokine expression. Therefore, this study aimed to investigate the therapeutic effects of cold plasma on psoriasis. METHODS: In psoriasis HaCaT cells with cold plasma, we confirmed the expression of inflammatory cytokines involved in psoriasis formation and MAPK pathway, cell cycle, and apopt

Arch Physiol Biochem. 2024 Oct 24:1-13. doi: 10.1080/13813455.2024.2407547. Online ahead of print. ABSTRACT CONTEXT: Insulin resistance and a disturbed lipid profile are common associations with type 2 diabetes mellitus (T2DM) and different skin diseases, particularly psoriasis (PsO). OBJECTIVES: We investigated potential therapeutic mechanisms of metformin in a murine animal model of psoriasiform lesions in T2DM. MATERIALS AND METHODS: Forty-two rats were randomly divided into control, PsO, and

J Eur Acad Dermatol Venereol. 2024 Apr 9. doi: 10.1111/jdv.20004. Online ahead of print. NO ABSTRACT PMID:38590284 | DOI:10.1111/jdv.20004 Den ganzen Artikel lesen

J Eur Acad Dermatol Venereol. 2024 Apr 9. doi: 10.1111/jdv.20004. Online ahead of print. NO ABSTRACT PMID:38590284 | DOI:10.1111/jdv.20004 Den ganzen Artikel lesen

F1000Res. 2024 Dec 6;13:1494. doi: 10.12688/f1000research.159565.1. eCollection 2024. ABSTRACT This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell-related gene upregulation while detailing unique features such as neutrophil involvement in PPP and lipid antigen processing in DPE. We e

FEBS Open Bio. 2025 Jan 17. doi: 10.1002/2211-5463.13969. Online ahead of print. ABSTRACT Dimethyl fumarate (DMF) is an anti-inflammatory and immunoregulatory medication used to treat multiple sclerosis (MS) and psoriasis. Its skin sensitization property precludes its topical use, which is unfortunate for the treatment of psoriasis. Isosorbide di-(methyl fumarate) (IDMF), a novel derivative of DMF, was synthesized to circumvent this adverse reaction and unlock the potential of topical delivery,

J Eur Acad Dermatol Venereol. 2024 Jun 21. doi: 10.1111/jdv.20192. Online ahead of print. NO ABSTRACT PMID:38959368 | DOI:10.1111/jdv.20192 Den ganzen Artikel lesen

J Inflamm Res. 2024 Sep 24;17:6707-6721. doi: 10.2147/JIR.S472338. eCollection 2024. ABSTRACT PURPOSE: Recent studies have shown that novel biologics may provide significant clinical benefits for patients with generalized pustular psoriasis (GPP). Ustekinumab and secukinumab have been approved in Japan for GPP treatment in adult patients. However, the differences in efficacy and safety of these two drugs in GPP are not known. AIM: Based on the genetic background, we aimed to compare the efficacy

Ital J Dermatol Venerol. 2024 Dec;159(6):599-606. doi: 10.23736/S2784-8671.24.07914-3. ABSTRACT BACKGROUND: Biologic drugs have revolutionized the treatment of psoriasis and other chronic inflammatory diseases. In recent years, numerous biosimilar molecules that target cytokines such as TNF-alpha or its receptors have been developed. The approval of biosimilars has made it possible to reduce the costs of biologic drugs, thereby increasing access to these therapies for more patients and enhancing

Arch Dermatol Res. 2025 Jan 18;317(1):291. doi: 10.1007/s00403-024-03786-4. ABSTRACT This study aims to explore the measurement agreement between direct and indirect health utility measures in four chronic dermatological conditions (atopic dermatitis, hidradenitis suppurativa, pemphigus, psoriasis). Outpatients survey data collected between 2015 and 2021 were analysed. Health-related quality of life (HRQoL) outcome measures included time trade-off (TTO), EQ-5D-5L and Dermatology Life Quality Ind