Aus Pubmed

Phytother Res. 2025 Jan 6. doi: 10.1002/ptr.8426. Online ahead of print. ABSTRACT Safe and effective treatments for psoriasis are limited. Anisole is an active ingredient in citrus and basil volatile oils; however, its potential for psoriasis treatment remains unexplored. To investigate the effects and mechanism of anisole transdermal administration as a treatment for psoriasis. Imiquimod (IMQ) was used to establish a C57 mouse psoriasis model. The severity of psoriasis lesions in each group was

Pharm Nanotechnol. 2024 Dec 30. doi: 10.2174/0122117385336297241210053845. Online ahead of print. ABSTRACT Introduction/ Background: This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment. MATERIALS AND METHODS: The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%). RESULTS: The ge

Br J Health Psychol. 2025 Feb;30(1):e12778. doi: 10.1111/bjhp.12778. ABSTRACT OBJECTIVES: Skin conditions carry a substantial psychological burden but support for patients is limited. Digital technology could support patient self-management; we found preliminary evidence for the effectiveness and acceptability of digital psychological interventions for adults living with skin conditions. We have, therefore, developed a complex digital intervention called MiDerm with patients. This qualitative st

J Am Acad Dermatol. 2025 Jan 3:S0190-9622(25)00007-6. doi: 10.1016/j.jaad.2024.12.035. Online ahead of print. NO ABSTRACT PMID:39756616 | DOI:10.1016/j.jaad.2024.12.035 Den ganzen Artikel lesen

J Nippon Med Sch. 2024;91(6):534-540. doi: 10.1272/jnms.JNMS.2024_91-613. ABSTRACT BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is positively associated with the prevalence and severity of psoriasis. The fibrosis-4 (FIB-4) index was developed to predict significant liver fibrosis. Using the FIB-4 index, the present study evaluated screening data for liver fibrosis, including MASLD, in patients with refractory psoriasis treated with biologics. METHODS: All adult pa

Chem Pharm Bull (Tokyo). 2025;73(1):1-17. doi: 10.1248/cpb.c24-00598. ABSTRACT 2α-Functionalization of 1α,25-dihydroxyvitamin D3 (active vitamin D3) A-ring enhances binding affinity for the vitamin D receptor (VDR) and prolongs the half-life in target cells due to gaining resistance to CYP24A1-dependant metabolism. The wide variety of modified A-ring precursor enynes for Trost coupling with CD-ring bromoolefin were synthesized from d-glucose. The A-ring modification provided potent, selective bi

J Prosthodont Res. 2025 Jan 3. doi: 10.2186/jpr.JPR_D_24_00061. Online ahead of print. ABSTRACT PURPOSE: Psoriasis is a complex, chronic inflammatory keratosis of unclear origin that is challenging to treat. In patients with psoriasis suspected of having metal allergies, the removal of oral metallic prostheses contributes to the alleviation of psoriasis symptoms. However, the relationship and mechanism of the metal removal effect and improvement in psoriasis symptoms in patients with metal aller

J Control Release. 2025 Jan 3:S0168-3659(25)00003-3. doi: 10.1016/j.jconrel.2025.01.001. Online ahead of print. ABSTRACT The immunosuppressive tumor microenvironment (TME) plays a crucial role in the progression and treatment resistance of melanoma. Modulating the TME is thus a key strategy for enhancing therapeutic outcomes. Recent studies have identified clonidine (CLD), an α2-adrenergic receptor agonist, as a promising agent that enhances T lymphocyte infiltration and reduces myeloid-derived

Clin Dermatol. 2025 Jan 3:S0738-081X(25)00001-X. doi: 10.1016/j.clindermatol.2025.01.001. Online ahead of print. ABSTRACT There is a significant amount of research examining the link between psoriasis and common mental health disorders; however, studies on less common psychiatric disorders, such as bipolar disorder (BD), remain limited. We conducted a systematic review of studies in the PubMed and Cochrane databases that explored the relationship between BD and psoriasis. Additionally, we evalua

J Pediatr. 2024 Dec 12:114436. doi: 10.1016/j.jpeds.2024.114436. Online ahead of print. ABSTRACT OBJECTIVES: To examine pediatrician diagnostic skill development of dermatology image-based cases via a web-based tool and to determine case-level variables that were associated with diagnostic error. STUDY DESIGN: This was a multi-center, prospective, cross-sectional study. A convenience sample of pediatric trainees and attendings were eligible for participation. Using a web-based tool, physicians p

Explore (NY). 2024 Dec 10;21(1):103098. doi: 10.1016/j.explore.2024.103098. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disease that can present in various phenotypes, with the most common form being plaque psoriasis. Currently, no type of psoriasis can be cured, and existing treatment options are associated with certain safety concerns. In recent years, traditional Chinese medicine has achieved great results in treating psoriasis. Cupping therapy is a

J Trace Elem Med Biol. 2024 Dec 10;87:127580. doi: 10.1016/j.jtemb.2024.127580. Online ahead of print. ABSTRACT BACKGROUND: Trichophyton rubrum is a widespread human pathogenic fungus, colonizing keratinized tissue of outer body-parts. Thereby, the pathogen is relying on nutrients available from the host. The invasive mechanism of the pathogen is relaying on secreted proteases, which hydrolyze skin-proteins for subsequent up-take. METHODS: In this study, we analyzed the gene expression of secret

Hum Immunol. 2024 Dec 13;86(1):111218. doi: 10.1016/j.humimm.2024.111218. Online ahead of print. ABSTRACT BACKGROUND: Immunosenescence, characterized by age-related changes in the immune system, may contribute to the onset and progression of psoriasis, a condition whose incidence increases with age and often requires intensified medication in older patients. METHODS: This study utilized bioinformatics analyses to identify differentially expressed immunosenescence-related genes in psoriasis patie

Arch Dermatol Res. 2024 Dec 14;317(1):118. doi: 10.1007/s00403-024-03617-6. ABSTRACT Ulcerative colitis (UC) and psoriasis are highly correlated clinically; however, it is unclear whether they have a common pathophysiological mechanism. The purpose of this study is to investigate the important molecules and pathways that mediate the coexistence of UC and psoriasis through quantitative bioinformatics analysis of public RNA-sequencing databases. The UC (GSE38713) and psoriasis (GSE30999) datasets

Arch Dermatol Res. 2024 Dec 14;317(1):115. doi: 10.1007/s00403-024-03550-8. ABSTRACT Psoriasis is a chronic, relapsing, inflammatory skin disease that is caused by the immune system. Amygdalin possesses immune-modulating and anti-inflammatory effects. To explore the possible effects of amygdalin on psoriasis and its pathogenesis of action, we examined the effects of amygdalin on imiquimod-induced psoriasis, tape-stripping-induced skin barrier disruption, and investigated the potential mechanism

Arch Dermatol Res. 2024 Dec 14;317(1):125. doi: 10.1007/s00403-024-03607-8. ABSTRACT The genetic causality between cathepsin levels and autoimmune diseases (ADs) bidirectionally was investigated and the associated cancer risk was explored with Mendelian randomization. Mendelian randomization analyses were used to explore causal associations between cathepsin and 14 ADs. The final results came from a meta-analysis of two datasets to get a robust result. Furthermore, the potential carcinogenic eff

J Cutan Med Surg. 2024 Dec 14:12034754241302827. doi: 10.1177/12034754241302827. Online ahead of print. ABSTRACT BACKGROUND: Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis. OBJECTIVES: To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada. METHODS: A multicenter, retrospective study was conducted in Canada in adults with moderate-to-seve

Psychol Health. 2024 Dec 13:1-29. doi: 10.1080/08870446.2024.2434483. Online ahead of print. ABSTRACT BACKGROUND: Chronic skin conditions are common in youth. The developmental transition to young adulthood involves social, psychological and physical changes. Adolescents with chronic skin conditions may experience greater challenges than their healthy peers due to the addition of managing and coping with their condition. OBJECTIVE: This study explored experiences of transition from adolescence t

RMD Open. 2024 Dec 12;10(4):e004494. doi: 10.1136/rmdopen-2024-004494. ABSTRACT OBJECTIVES: To prospectively evaluate the effect of guselkumab through 48 weeks across various clinical outcomes in subgroups of patients with psoriatic arthritis (PsA) and inadequate response to tumour necrosis factor inhibitors (TNFi-IR) from the phase 3b COSMOS trial. Subgroups were defined by baseline demographics, disease characteristics and prior/ongoing therapies. METHODS: Patients with active PsA (tender join

J Dermatolog Treat. 2024 Dec;35(1):2420825. doi: 10.1080/09546634.2024.2420825. Epub 2024 Oct 27. ABSTRACT Introduction: Psoriasis is a chronic immune-mediated disease that can be challenging to treat, especially in patients with severe disease or high body weight. Tildrakizumab is a monoclonal antibody which inhibits IL-23, approved for moderate-to-severe psoriasis with a standard 100 mg dose. A 200 mg dose may provide greater efficacy for patients over 90 kg or with high disease burden. Method

Biostatistics. 2024 Oct 27:kxae039. doi: 10.1093/biostatistics/kxae039. Online ahead of print. ABSTRACT In life history analysis of data from cohort studies, it is important to address the process by which participants are identified and selected. Many health studies select or enrol individuals based on whether they have experienced certain health related events, for example, disease diagnosis or some complication from disease. Standard methods of analysis rely on assumptions concerning the inde

Lancet. 2024 Oct 26;404(10463):1679-1692. doi: 10.1016/S0140-6736(24)01750-1. ABSTRACT Biological monoclonal antibody drugs inhibit overactive cytokine signalling that drives chronic inflammatory disease in different organ systems. In the last 10 years, interleukin (IL)-23 inhibitors have attained an important position in the treatment of psoriatic skin and joint disease as well as inflammatory bowel diseases. Addressing an upstream pathological mechanism shared between these disorders, this dru

Arch Dermatol Res. 2024 Oct 26;316(10):705. doi: 10.1007/s00403-024-03425-y. ABSTRACT To systematically evaluate clinical features and effects of cyclosporine in the treatment of psoriasis. Databases including Web of Science, PubMed, The Cochrane Library, Embase, CNKI, Wan Fang, and VIP were electronically searched for studies on the use of cyclosporine in the treatment of psoriasis, from inception to March 2024. Two reviewers independently screened the literature, extracted data, and assessed t

Arch Dermatol Res. 2024 Oct 26;316(10):717. doi: 10.1007/s00403-024-03465-4. ABSTRACT It has been reported that many people with psoriasis have been diagnosed with secondary IgA nephropathy (IgAN). However, the mechanisms behind the association between psoriasis and IgAN have not been well clarified. The connection between psoriasis and IgAN deserves deeper exploration. Mendelian randomization (MR) analysis would be employed to explore the link of causality between IgAN and psoriasis, psoriasis

Life (Basel). 2024 Oct 17;14(10):1318. doi: 10.3390/life14101318. ABSTRACT (1) Introduction: Topical dithranol is still commonly used today as an effective treatment for psoriasis. Dithranol treatment is often supplemented with balneotherapy, which has been shown to increase effectiveness and reduce side effects. The inorganic salts (sulfhide, selenium, zinc) are usually thought to be responsible for the effect. The antioxidant effect of the waters is thought to be behind the therapeutic effect,