Aus Pubmed

Bioact Mater. 2024 Dec 20;46:229-241. doi: 10.1016/j.bioactmat.2024.12.015. eCollection 2025 Apr. ABSTRACT Reactive oxygen species (ROS) at elevated levels trigger oxidative DNA damage, which is a significant factor in psoriasis exacerbation. However, normal ROS levels are essential for cell signaling, cell growth regulation, differentiation, and immune responses. To address this, we developed ROS control strategies inspired by compensatory effects. DNA nanostructures with the advantage of being

Front Biosci (Landmark Ed). 2024 Aug 30;29(9):311. doi: 10.31083/j.fbl2909311. ABSTRACT BACKGROUND: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors. N6-methyladenosine methylation (m6A) is the most prevalent RNA modification implicated in various diseases; however, its role in psoriasis still needs to be further explored. We aimed to explore the mechanisms underlying the effects of m6A in psoriasis pathogenesis, prom

Front Physiol. 2024 May 7;15:1346971. doi: 10.3389/fphys.2024.1346971. eCollection 2024. ABSTRACT The epidermis, the outermost layer of the skin, serves as a protective barrier against external factors. Epidermal differentiation, a tightly regulated process essential for epidermal homeostasis, epidermal barrier formation and skin integrity maintenance, is orchestrated by several players, including signaling molecules, calcium gradient and junctional complexes such as gap junctions (GJs). GJ prot

Dermatol Ther (Heidelb). 2025 Mar 6. doi: 10.1007/s13555-024-01317-7. Online ahead of print. NO ABSTRACT PMID:40048065 | DOI:10.1007/s13555-024-01317-7 Den ganzen Artikel lesen

Dermatol Ther (Heidelb). 2024 Jun 3. doi: 10.1007/s13555-024-01167-3. Online ahead of print. NO ABSTRACT PMID:38831119 | DOI:10.1007/s13555-024-01167-3 Den ganzen Artikel lesen

Dermatol Ther (Heidelb). 2025 Jan 17. doi: 10.1007/s13555-024-01328-4. Online ahead of print. NO ABSTRACT PMID:39821856 | DOI:10.1007/s13555-024-01328-4 Den ganzen Artikel lesen

Rheumatol Int. 2024 Sep 2. doi: 10.1007/s00296-024-05687-1. Online ahead of print. NO ABSTRACT PMID:39218830 | DOI:10.1007/s00296-024-05687-1 Den ganzen Artikel lesen

Front Oncol. 2024 Mar 28;14:1331419. doi: 10.3389/fonc.2024.1331419. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fonc.2023.1185389.]. PMID:38606107 | PMC:PMC11008677 | DOI:10.3389/fonc.2024.1331419 Den ganzen Artikel lesen

Dermatology. 2024 Apr 8. doi: 10.1159/000536366. Online ahead of print. ABSTRACT BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and dis

Dermatology. 2024 Apr 8. doi: 10.1159/000536366. Online ahead of print. ABSTRACT BACKGROUND: Autosomal recessive congenital ichthyoses (ARCI) are a clinically heterogeneous group of keratinization disorders characterized by generalized skin scaling due to mutations in at least 12 genes. The aim of our study was to assess disease severity, phenotypic and ultrastructural features and to evaluate their association with genetic findings in ARCI patients. METHODS: Clinical signs and symptoms, and dis

J Invest Dermatol. 2024 Oct 22:S0022-202X(24)02161-4. doi: 10.1016/j.jid.2024.09.012. Online ahead of print. ABSTRACT As medicine advances, cures are being found for diseases that were previously considered incurable, as is the case for some types of cancer. Traditionally, the term cure is reserved for resolution of disease, both at a clinical and a molecular level, which continues after cessation of treatment. Biologic therapies have revolutionized the definition of remission in severe psoriasi

Transplant Cell Ther. 2024 Sep;30(9S):S513-S533. doi: 10.1016/j.jtct.2024.05.020. ABSTRACT Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentations. This review provides an overview of clinical presentation, diagnosis and differential diagnosis, grading,

Sci Rep. 2024 Oct 22;14(1):24922. doi: 10.1038/s41598-024-75190-x. ABSTRACT The availability of a number of bDMARDs with different mechanism of action increases potential treatment pathways in psoriatic arthritis (PsA). In clinical practice, following the failure of one bDMARD, it is normal to consider which options are the best for switching strategy. In most cases this choice involves IL17i and TNFi. The main aim of this study was to compare the effectiveness of cycling (from TNFi to another T

Int J Womens Dermatol. 2024 Jun 7;10(2):e152. doi: 10.1097/JW9.0000000000000152. eCollection 2024 Jun. ABSTRACT BACKGROUND: In some hidradenitis suppurativa (HS) clinical trial study arms, there is an unexpected decline in efficacy between the penultimate visit and the prespecified primary endpoint week, which we have termed a "wobble." OBJECTIVE: We aimed to establish how often study arms in HS programs wobble. METHODS: In a retrospective review, we identified HS clinical trials listed on Clini

Front Immunol. 2024 Mar 28;15:1304888. doi: 10.3389/fimmu.2024.1304888. eCollection 2024. ABSTRACT BACKGROUND: Prior research has indicated a link between psoriasis and the susceptibility to breast cancer (BC); however, a definitive causal relationship remains elusive. This study sought to elucidate the causal connection and shared underlying mechanisms between psoriasis and BC through bidirectional Mendelian randomization (MR) and bioinformatic approaches. METHODS: We employed a bidirectional M

Int Immunopharmacol. 2024 Apr 11;133:112033. doi: 10.1016/j.intimp.2024.112033. Online ahead of print. ABSTRACT Psoriasis is an immuno-inflammatory disease characterized by excessive keratinocyte proliferation, requiring extensive lipids. 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1) is an essential enzyme in the mevalonate pathway, involved in cholesterol synthesis and the inflammatory response. However, the role of HMGCS1 in psoriasis has remained elusive. This study aims to elucid

Dermatol Ther (Heidelb). 2024 Oct 4. doi: 10.1007/s13555-024-01277-y. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic immune-mediated skin disease with several comorbidities and a considerable influence on quality of life. Many patients with moderate-to-severe psoriasis are undertreated and have a substantial disease duration before effective treatment is started. This study analyzed patient and disease characteristics and time to effective treatment of patients with psorias

Br J Dermatol. 2024 Oct 22:ljae406. doi: 10.1093/bjd/ljae406. Online ahead of print. ABSTRACT BACKGROUND: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in the United States, European Union, Japan, South Korea, China, and other countries for treatment of moderate-to-severe plaque psoriasis. OBJECTIVE: To evaluate the efficacy and safety of deucravacitinib in Asian patients with moderate to severe plaque psoriasis. METHODS: In the 52-week, blinded, phase

Sci Rep. 2024 Sep 2;14(1):20320. doi: 10.1038/s41598-024-71340-3. ABSTRACT Asynchronous teledermatology (TD) has shown promise in improving access to dermatological care, yet studies reveal varied methodologies and results. This study aimed to design a mobile app using the store-and-forward model, marking a pioneering effort in Iran to facilitate written documentation of patient history and skin lesion imagery for accurate diagnosis. Conducted from July 2022 to July 2023, this study involved the

Clin Epidemiol. 2024 Jun 4;16:395-407. doi: 10.2147/CLEP.S445120. eCollection 2024. ABSTRACT PURPOSE: This research aimed to develop and validate a META-algorithm combining individual immune-mediated inflammatory disease (IMID)-specific algorithms to identify the exact IMID indications for incident biological drug users from claims data within the context of the Italian VALORE project. METHODS AND PATIENTS: All subjects with at least one dispensing of TNF-alpha inhibitors, anti-interleukin agent

Int J Dermatol. 2024 Apr 9. doi: 10.1111/ijd.17146. Online ahead of print. ABSTRACT BACKGROUND: Social comparison, the process of evaluating one's characteristics in relation to others, influences individuals' self-perception and behavior. However, instruments are scarce for assessing social comparison in the medical setting. OBJECTIVES: Our aim was to develop and validate a new scale for assessing social comparison. MATERIALS AND METHODS: Seven statements were developed, encompassing the percei

Eur J Pharm Biopharm. 2024 Oct 9:114523. doi: 10.1016/j.ejpb.2024.114523. Online ahead of print. ABSTRACT The aim of this study was to investigate the impact of using microneedle patches in addition to topical therapy for the treatment of psoriasis. Using continuous liquid interface production (CLIP) 3D printing we manufactured round microneedle array patches (MAPs) with a diameter of 14 mm. Needle geometries were varied from square pyramidal, conical, and obelisk, with varied needle lengths of

Clin Case Rep. 2024 May 31;12(6):e9037. doi: 10.1002/ccr3.9037. eCollection 2024 Jun. ABSTRACT KEY CLINICAL MESSAGE: The use of phototherapy is highly effective in treating various skin diseases. In this study, the aim is to present vesicular and blister lesions in patients treated with UVB for psoriasis. It is advisable to consider the possibility of BSLE in cases of vesiculobullous lesions following phototherapy, along with other potential diagnoses. ABSTRACT: Bullous systemic lupus erythemato

Pharm Nanotechnol. 2024 Dec 30. doi: 10.2174/0122117385336297241210053845. Online ahead of print. ABSTRACT Introduction/ Background: This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment. MATERIALS AND METHODS: The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%). RESULTS: The ge

J Dermatol. 2024 Jun 7. doi: 10.1111/1346-8138.17317. Online ahead of print. NO ABSTRACT PMID:38847289 | DOI:10.1111/1346-8138.17317 Den ganzen Artikel lesen