Aus Pubmed

Exp Dermatol. 2024 Oct;33(10):e70003. doi: 10.1111/exd.70003. ABSTRACT Psoriasis is a chronic autoimmune disease with a long disease course and frequent relapse characteristics. It is now recognised to be associated with epidermal environments of inflammatory cytokines. However, its pathogenesis is still not completely clear. We found the haemorheology of psoriatic patients to be abnormal, and ageing and deformed erythrocytes increased in the blood. The abnormal erythrocytes were more likely to

Cancer Sci. 2024 Oct 22. doi: 10.1111/cas.16378. Online ahead of print. ABSTRACT Our previous research has demonstrated that P2RY6 functions as an oncogene in DMBA/TPA-induced two-stage chemical skin carcinogenesis in mice. However, considering that human skin cancer is predominantly attributed to UV radiation from sunlight, additional investigations are needed to elucidate the role of P2RY6 in UVB-induced skin carcinogenesis. Surprisingly, we found that P2ry6-deficient mice exhibited marked pro

Mult Scler. 2024 Oct 22:13524585241290986. doi: 10.1177/13524585241290986. Online ahead of print. NO ABSTRACT PMID:39435541 | DOI:10.1177/13524585241290986 Den ganzen Artikel lesen

iScience. 2024 Sep 16;27(10):110984. doi: 10.1016/j.isci.2024.110984. eCollection 2024 Oct 18. ABSTRACT Mast cells (MCs) are tissue-resident immune cells known to degranulate in response to FcεRI crosslinking or MRGPRX2 engagement. MCs are found close to nerves, but the mechanisms that regulate this privileged localization remain unclear. Here, we investigated MRGPRX2 expression patterns and specific activities in MCs. We show that MRGPRX2 expression is heterogeneous in human MC (hMC) progenitor

J Transl Autoimmun. 2024 Oct 2;9:100251. doi: 10.1016/j.jtauto.2024.100251. eCollection 2024 Dec. ABSTRACT BACKGROUND: Mitochondrial DNA plays a crucial role in the pathophysiology of autoimmune diseases (ADs). However, the association between mitochondrial DNA copy number (mtDNA-CN) and ADs risk is controversial. In this study, Mendelian randomization (MR) analysis and meta-analysis were performed using three sets of independent instrumental variables (IVs) to investigate the potential associat

Skinmed. 2024 Oct 22;22(5):387-389. eCollection 2024. ABSTRACT A 79-year-old woman with psoriasis presented to the emergency department with new-onset eruptions on the trunk, extremities, and oral mucosa for 8-9 days. For psoriasis, she had been taking 15 mg of methotrexate weekly for over 18 years, and had discontinued folic acid a few months prior to this. PMID:39433528 Den ganzen Artikel lesen

J Am Acad Dermatol. 2024 Oct 10:S0190-9622(24)02997-9. doi: 10.1016/j.jaad.2024.09.060. Online ahead of print. NO ABSTRACT PMID:39395444 | DOI:10.1016/j.jaad.2024.09.060 Den ganzen Artikel lesen

Br J Dermatol. 2024 Oct 12:ljae391. doi: 10.1093/bjd/ljae391. Online ahead of print. ABSTRACT BACKGROUND: Air pollution and genetic risk have been found to contribute to both onset and development of psoriasis. However, the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of incident psoriasis remains unknown. OBJECTIVES: Our study aimed to assess the association between joint exposure to multiple air pollutants and the risk of psoriasis and the modificat

Australas J Dermatol. 2024 Oct 12. doi: 10.1111/ajd.14368. Online ahead of print. NO ABSTRACT PMID:39394861 | DOI:10.1111/ajd.14368 Den ganzen Artikel lesen

J Eur Acad Dermatol Venereol. 2024 Oct 12. doi: 10.1111/jdv.20367. Online ahead of print. ABSTRACT Targeted biologic drugs and small molecules have transformed the psoriasis treatment landscape in recent years. The Belgian healthcare system, in common with many others across Europe, must balance the burgeoning use of these transformative, yet expensive, drugs with the sustainable use of limited resources. Drawing on recent updates to the EuroGuiDerm and the German S2 psoriasis guidelines, eight

Sci Rep. 2024 Oct 11;14(1):23848. doi: 10.1038/s41598-024-75069-x. ABSTRACT The epidermal infiltration of neutrophils is a hallmark of psoriasis (PSO) and its activation leads to the release of neutrophil extracellular traps (NETs). However, the molecular mechanism of NETs-related genes (NETRGs) has not been extensively studied in PSO. To define NETs-related-biomarkers for PSO. The GSE13355 and GSE78097 datasets, and NETRGs gene set were included in this study. The datasets used in this study we

Sci Rep. 2024 Oct 11;14(1):23794. doi: 10.1038/s41598-024-75833-z. ABSTRACT Assessment of side effects associated with COVID-19 vaccination is required to monitor safety issues and acceptance of vaccines in the long term. We found a significant knowledge gap in the safety profile of COVID-19 vaccines in Bangladesh. We enrolled 1805 vaccine recipients from May 5, 2021, to April 4, 2023. Kruskal-Wallis test and χ2 test were performed. Multivariable logistic regression was also performed. First, se

Sci Rep. 2024 Oct 12;14(1):23866. doi: 10.1038/s41598-024-72951-6. ABSTRACT The purpose of the current work was to develop and characterize ethosomes of vitamin D3 gel that could more effectively work against psoriasis. Psoriasis is a chronic immune-mediated inflammatory skin disease. Due to vitamin D3 role in proliferation and maturation of keratinocytes, it has become an important local therapeutic option in the treatment of psoriasis. In this research we have initiated worked on ethosomes gel

Eur J Pharm Biopharm. 2024 Oct 9:114523. doi: 10.1016/j.ejpb.2024.114523. Online ahead of print. ABSTRACT The aim of this study was to investigate the impact of using microneedle patches in addition to topical therapy for the treatment of psoriasis. Using continuous liquid interface production (CLIP) 3D printing we manufactured round microneedle array patches (MAPs) with a diameter of 14 mm. Needle geometries were varied from square pyramidal, conical, and obelisk, with varied needle lengths of

J Am Acad Dermatol. 2024 Oct 9:S0190-9622(24)02990-6. doi: 10.1016/j.jaad.2024.10.006. Online ahead of print. NO ABSTRACT PMID:39393547 | DOI:10.1016/j.jaad.2024.10.006 Den ganzen Artikel lesen

J Invest Dermatol. 2024 Oct 9:S0022-202X(24)02180-8. doi: 10.1016/j.jid.2024.08.039. Online ahead of print. ABSTRACT Imaging Mass Cytometry (IMC) is a technology that enables comprehensive analysis of cellular phenotypes at the tissue level. We performed a multi-parameter characterization of structural and immune cell populations in psoriatic skin and synovial tissue samples aimed at characterizing immune cell differences in patients with psoriasis, psoriatic arthritis (PsA). A panel of 33 antib

Chem Biodivers. 2024 Oct 6:e202401821. doi: 10.1002/cbdv.202401821. Online ahead of print. ABSTRACT Thymus linearis from the Himalayan woodlands of Gilgit Baltistan, Pakistan, is a phytomedicine that has not been well-studied. Traditionally, it is recognized for its potential in treating conditions such as dermatitis, psoriasis, weight loss, and discomfort. The study investigates the wound-healing properties of methanolic extracts from the plant's stems, leaves, and roots. GC-MS disclosed cadave

Transplant Cell Ther. 2024 Sep;30(9S):S513-S533. doi: 10.1016/j.jtct.2024.05.020. ABSTRACT Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentations. This review provides an overview of clinical presentation, diagnosis and differential diagnosis, grading,

J Dermatolog Treat. 2024 Dec;35(1):2411849. doi: 10.1080/09546634.2024.2411849. Epub 2024 Oct 6. ABSTRACT Background and objectives: Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder affecting 30% of psoriatic patients. Effective treatment, especially with biologics like IL-17 and TNF inhibitors, is vital for improving patient outcomes. This study aimed to compare the efficacy of secukinumab and adalimumab in PsA patients through clinical and ultrasonographic evaluatio

Arch Dermatol Res. 2024 Oct 5;316(9):661. doi: 10.1007/s00403-024-03410-5. ABSTRACT Psoriasis, an inflammatory disease, is largely mediated by T-helper 17 cytokines. We have previously identified the immune system-released activating agent (Israa) as a novel gene that connects the nervous and immune systems. This research aims to investigate the role of the Israa gene in psoriasis in vivo using the imiquimod-induced psoriasis model. We established the model in C57BL/6 wildtype mice, which were t

Arch Dermatol Res. 2024 Oct 5;316(9):659. doi: 10.1007/s00403-024-03405-2. ABSTRACT Vitiligo is a chronic autoimmune disorder characterized by progressive skin depigmentation. Vitiligo significantly impacts patients' quality of life, contributing to psychological and social burdens. Despite readily available therapeutic options, many cases remain refractory to treatment, highlighting the critical need for safer and more effective therapies. Currently, ruxolitinib is the only FDA-approved medicat

Eur J Med Res. 2024 Oct 5;29(1):487. doi: 10.1186/s40001-024-02088-9. ABSTRACT Cold atmospheric plasma (CAP) technology has emerged as a revolutionary therapeutic technology in dermatology, recognized for its safety, effectiveness, and minimal side effects. CAP demonstrates substantial antimicrobial properties against bacteria, viruses, and fungi, promotes tissue proliferation and wound healing, and inhibits the growth and migration of tumor cells. This paper explores the versatile applications

J Ethnopharmacol. 2024 Oct 2:118882. doi: 10.1016/j.jep.2024.118882. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Sophocarpine is a bioactive compound extracted from the dried root of Sophorae Flavesentis Aiton, a plant that has been used for thousands of years for various conditions including skin itch and pain. Its antipruritic and analgesic effects are suggested in publications, while the molecular mechanisms underneath interacting with TRP channels are not understood. AIM

Postepy Biochem. 2024 Sep 17;70(3):307-314. doi: 10.18388/pb.2021_554. Print 2024 Sep 30. ABSTRACT Vitamin C is one of the most important and necessary nutrient for human health, which has great potential as cosmeceutic, which protects health and the skin good condition. Thru the collagen biosynthesis stimulation it affects to the physiology of human skin, participating in the hydroxylation process of proline and lysine, and participates in tissue reconstruction while wound healing. Deficiency o

Expert Opin Drug Saf. 2024 Oct 4. doi: 10.1080/14740338.2024.2412221. Online ahead of print. ABSTRACT OBJECTIVE: The study aims to thoroughly assess the adverse events related to infections and infestations associated with biological agents used for psoriasis using the U.S. Food and Drug Administration's Adverse Event Reporting System (FAERS) database. METHODS: We analyzed FAERS data from the first quarter of 2004 to the fourth quarter of 2023. The study included TNF-α inhibitors (etanercept, in