Aus Pubmed

Psychol Health. 2024 Dec 13:1-29. doi: 10.1080/08870446.2024.2434483. Online ahead of print. ABSTRACT BACKGROUND: Chronic skin conditions are common in youth. The developmental transition to young adulthood involves social, psychological and physical changes. Adolescents with chronic skin conditions may experience greater challenges than their healthy peers due to the addition of managing and coping with their condition. OBJECTIVE: This study explored experiences of transition from adolescence t

BMJ Open. 2024 May 16;14(5):e079540. doi: 10.1136/bmjopen-2023-079540. ABSTRACT OBJECTIVES: Patients' preferences, values and contexts are important elements of the shared decision-making (SDM) process. We captured those elements into the concept of 'personal perspective elicitation' (PPE), which reflects the need to elicit patients' preferences, values and contexts in patient-clinician conversations. We defined PPE as: 'the disclosure (either elicited by the clinician or spontaneously expressed

J Dermatol. 2025 Jan 15. doi: 10.1111/1346-8138.17622. Online ahead of print. ABSTRACT Itch is a prominent symptom in many cutaneous disorders, including atopic dermatitis (AD), prurigo nodularis, and psoriasis. Itch is also a common but overlooked concern in patients with hidradenitis suppurativa (HS). Currently, the mechanisms underlying itch in HS remain unclear. To gain a better understanding, we reviewed the literature on pruritus in HS and other itch-predominant disorders, AD, and psoriasi

Phytother Res. 2025 Jan 6. doi: 10.1002/ptr.8426. Online ahead of print. ABSTRACT Safe and effective treatments for psoriasis are limited. Anisole is an active ingredient in citrus and basil volatile oils; however, its potential for psoriasis treatment remains unexplored. To investigate the effects and mechanism of anisole transdermal administration as a treatment for psoriasis. Imiquimod (IMQ) was used to establish a C57 mouse psoriasis model. The severity of psoriasis lesions in each group was

Cureus. 2024 Dec 16;16(12):e75810. doi: 10.7759/cureus.75810. eCollection 2024 Dec. ABSTRACT Introduction The COVID-19 pandemic sparked an interest in skincare with the closure of spas and salons. Skincare, one of TikTok's most popular dermatology-related hashtags, received hundreds of millions of views. The American Academy of Dermatology (AAD) shared facial cleansing recommendations; however, how many people follow them is unclear. Studies have shown a good daily facial cleansing and moisturiz

Pharmaceuticals (Basel). 2024 Oct 16;17(10):1378. doi: 10.3390/ph17101378. ABSTRACT (1) Background/Objectives: Nail psoriasis (NP) is a chronic and difficult-to-treat disease, which causes significant social stigma and impairs the patients' quality of life. Moreover, nail psoriasis is a true therapeutic challenge for clinicians. The presence of nail psoriasis can be part of a severe form of psoriasis and can have predictive value for the development of psoriatic arthritis. Our real-world-evidenc

J Invest Dermatol. 2025 Jan 8:S0022-202X(24)03024-0. doi: 10.1016/j.jid.2024.11.007. Online ahead of print. ABSTRACT Melanoma is a devastating form of skin cancer characterized by a high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy and targeted therapies have significantly revolutionized melanoma treatment, the majority of patients fail to achieve durable responses, highlighting the urgent need for novel therapeutic strategies. Ferroptosis, an iron-d

Rheumatol Ther. 2024 Jun 7. doi: 10.1007/s40744-024-00680-3. Online ahead of print. ABSTRACT INTRODUCTION: Biologic therapies are licensed for both psoriasis (PsO) and psoriatic arthritis (PsA) with some electronic medical record data suggest that IL (Interleukin)-23 blockers might be more protective in PsA prevention than TNF blockers; however, the findings have been inconsistent. Higher Psoriasis Area and Severity Index (PASI) scores have also been linked to an increased PsA risk. To clarify t

Folia Biol (Praha). 2024;70(1):53-61. doi: 10.14712/fb2024070010053. ABSTRACT Psoriasis is a chronic non-contagious autoimmune disease. Gallic acid is a natural compound with potential health benefits, including antioxidant, anticancer, antiviral and antibacterial properties. Nevertheless, the influence of gallic acid on psoriasis has not been fully determined. This investigation aimed to discover the effect of gallic acid on psoriasis. Thirty-one pairs of psoriatic skin tissues and healthy adul

Chem Biodivers. 2024 Oct 6:e202401821. doi: 10.1002/cbdv.202401821. Online ahead of print. ABSTRACT Thymus linearis from the Himalayan woodlands of Gilgit Baltistan, Pakistan, is a phytomedicine that has not been well-studied. Traditionally, it is recognized for its potential in treating conditions such as dermatitis, psoriasis, weight loss, and discomfort. The study investigates the wound-healing properties of methanolic extracts from the plant's stems, leaves, and roots. GC-MS disclosed cadave

Medicine (Baltimore). 2024 May 10;103(19):e38055. doi: 10.1097/MD.0000000000038055. ABSTRACT Multiple studies have indicated a potential correlation between immune-mediated inflammatory diseases (IMIDs) and Frozen shoulder (FS). To explore the genetic causal relationship between IMIDs and FS using 2-sample Mendelian randomization (MR) analysis. Genome-wide association study (GWAS) summary data for FS were obtained from Green's study, while data for 10 IMIDs were sourced from the FinnGen Consorti

Nanomaterials (Basel). 2024 Mar 29;14(7):610. doi: 10.3390/nano14070610. ABSTRACT Psoriasis, a chronic inflammatory skin disease induced by various factors, including genetic factors, immune factors, environmental factors, and psychological factors, is characterized by thickening of the epidermis, excessive proliferation of keratinocytes, abnormal differentiation, and an excessive inflammatory response. Traditional treatments for psoriasis still face challenges because of limited curative effect

Life (Basel). 2024 Oct 13;14(10):1297. doi: 10.3390/life14101297. ABSTRACT (1) Background: The purpose of this study is to compare the rate of COVID-19 vaccination among psoriasis patients internationally and to correlate it with their treatment regimens. (2) Methods: We conducted a cross-sectional study from January 2021 to October 2022 among adults in the United States (US), Chile, China, Switzerland, and Singapore using the Global Healthcare Study on Psoriasis survey. (3) Results: A total of

BMC Womens Health. 2025 Mar 6;25(1):101. doi: 10.1186/s12905-025-03625-2. ABSTRACT BACKGROUND: Skin diseases are a category of chronic conditions that often impact patients' appearance, potentially leading to psychological issues, including sexual dysfunction. The present study is an attempt to determine the global prevalence of female sexual dysfunction (FSD) in women with skin diseases. METHODS: For this systematic review and meta-analysis, databases including PubMed, Web of Science, Scopus, S

Microorganisms. 2024 Oct 3;12(10):2010. doi: 10.3390/microorganisms12102010. ABSTRACT The skin plays a crucial role in maintaining homeostasis and protecting against external aggressors. Recent research has highlighted the potential of probiotics and postbiotics in dermatological treatments and skincare. These beneficial microorganisms interact with the skin microbiota, modulate the immune response, and enhance the skin barrier, offering a promising therapeutic avenue for various skin conditions

J Autoimmun. 2025 Jan 13;151:103361. doi: 10.1016/j.jaut.2025.103361. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin disease with etiologies related to genetics, immunity, and the environment. It is characterized by excessive proliferation of keratinocytes and infiltration of inflammatory immune cells. Glycosylation is a post-translational modification of proteins that plays important roles in cell adhesion, signal transduction, and immune cell activation. Abnormal glyc

Biochem Pharmacol. 2025 Jan 8:116745. doi: 10.1016/j.bcp.2025.116745. Online ahead of print. ABSTRACT The pathogenesis of psoriasis involves hyperproliferation of epidermal keratinocytes and abnormal interactions between activated keratinocytes and infiltrating immune cells. Emerging evidence has shown that keratinocytes play essential roles in both the initiation and maintenance of psoriasis, suggesting that exposing keratinocytes to agents with antiproliferative and anti-inflammatory effects m

JAMA Dermatol. 2024 Apr 10. doi: 10.1001/jamadermatol.2024.0257. Online ahead of print. ABSTRACT IMPORTANCE: There is no US Food and Drug Administration-approved treatment for pityriasis rubra pilaris (PRP), and it is common for patients to fail to experience improvement with several systemic options. Involvement of interleukin (IL) 23 suggests a potential therapeutic target. OBJECTIVE: To determine whether guselkumab, an IL-23p19 inhibitor, provides clinical improvement for participants with PR

Dermatol Ther (Heidelb). 2024 Jul 3. doi: 10.1007/s13555-024-01206-z. Online ahead of print. ABSTRACT INTRODUCTION: Diagnosis of persistent erythematous, scaly patches, or plaques can be complex since psoriasis (Ps), eczematous dermatitis (ED), and mycosis fungoides (MF) can be considered. Dermoscopy, which is a noninvasive diagnostic tool, is commonly used to examine blood vessels, scales, and background color; however, research on hair shaft evaluation in inflammatory dermatoses remains scarce

Atheroscler Plus. 2024 Dec 13;59:32-38. doi: 10.1016/j.athplu.2024.12.002. eCollection 2025 Mar. ABSTRACT BACKGROUND AND AIMS: Vitamin D binding protein (DBP) serves a dual function as a vitamin D carrier and actin scavenger. Free DBP is present in high concentrations in serum, while a smaller pool is bound to lipoproteins like HDL and VLDL. The role of DBP's interaction with lipoproteins remains unclear. Given that HDL has been proposed to have both atheroprotective and anti-inflammatory proper

Dermatol Reports. 2023 Oct 16;16(2):9854. doi: 10.4081/dr.2023.9854. eCollection 2024 Jun 14. ABSTRACT Psoriasis is a chronic inflammatory skin disease that affects people all over the world. It is linked to the HLA-Cw6 allele, which is more common in Caucasians than in Asians and varies across ethnic groups. We investigated the association between the disease severity and the onset age of HLA-Cw6 prevalence in Vietnamese psoriasis patients. In 121 psoriasis patients and 30 healthy controls, we

Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print. ABSTRACT Interleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or infla

Ter Arkh. 2024 Jun 3;96(5):486-493. doi: 10.26442/00403660.2024.05.202704. ABSTRACT AIM: To study the frequency of hypogonadism (HG) in men with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and to evaluate the impact of HG on the course of RA and and concomitant diseases. MATERIALS AND METHODS: A single-stage continuous study included 170 men with RA, 57 men with AS and 85 men with PsA, who were hospitalized at the Nasonova Research Institute of Rheumatolo

Rheumatology (Oxford). 2024 May 17:keae263. doi: 10.1093/rheumatology/keae263. Online ahead of print. ABSTRACT OBJECTIVE: To present the characteristics of patients with potential difficult-to-treat (D2T) psoriatic arthritis (PsA). METHODS: We used data from the Greek multicentre registry of PsA patients. D2T-PsA was defined as follows: patients with at least 6-months disease duration, who have failed to at least 1 csDMARD and at least 2 bDMARDs/tsDMARDs with a different mechanism of action and

Hum Immunol. 2024 Dec 13;86(1):111218. doi: 10.1016/j.humimm.2024.111218. Online ahead of print. ABSTRACT BACKGROUND: Immunosenescence, characterized by age-related changes in the immune system, may contribute to the onset and progression of psoriasis, a condition whose incidence increases with age and often requires intensified medication in older patients. METHODS: This study utilized bioinformatics analyses to identify differentially expressed immunosenescence-related genes in psoriasis patie