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Dermatol Ther (Heidelb). 2024 Oct 4. doi: 10.1007/s13555-024-01277-y. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic immune-mediated skin disease with several comorbidities and a considerable influence on quality of life. Many patients with moderate-to-severe psoriasis are undertreated and have a substantial disease duration before effective treatment is started. This study analyzed patient and disease characteristics and time to effective treatment of patients with psorias

Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct 4. doi: 10.1007/s00210-024-03461-5. Online ahead of print. ABSTRACT Berberine (BBR), a Rhizoma Coptis-sourced isoquinoline alkaloid, is an effective drug for psoriasis treatment with its therapeutic mechanism remaining unclear. We delved into the mechanism of BBR affecting psoriatic skin inflammation by regulating keratinocyte pyroptosis. A psoriasis-like skin inflammation mouse model was induced by imiquimod (IMQ) and treated with BBR and a p38 acti

ACR Open Rheumatol. 2024 Oct 4. doi: 10.1002/acr2.11732. Online ahead of print. ABSTRACT OBJECTIVE: Group-level analyses from the phase 3 DISCOVER-2 trial of guselkumab demonstrated robust and durable improvements across psoriatic arthritis (PsA) domains. To specifically evaluate continuous disease control in individual patients, persistence of clinically relevant improvements was assessed, both at consecutive guselkumab dosing visits and over time. METHODS: Post hoc analyses included biologic-n

Cureus. 2024 Sep 3;16(9):e68556. doi: 10.7759/cureus.68556. eCollection 2024 Sep. ABSTRACT Psoriasis is a chronic inflammatory skin condition characterized by well-demarcated, erythematous plaques. Certain medications, including Angiotensin-Converting Enzyme (ACE) inhibitors, have been implicated as potential triggers for psoriasis flare-ups. We report the case of a 48-year-old Indian male with a history of well-controlled plaque psoriasis who experienced severe flare-ups after initiating ACE in

Cureus. 2024 Sep 3;16(9):e68569. doi: 10.7759/cureus.68569. eCollection 2024 Sep. ABSTRACT Psoriasis (PS) and inflammatory bowel disease (IBD) are immune-mediated chronic conditions that share pathophysiological processes, including immune system dysfunction, microbiome dysbiosis, and inflammatory pathways. These pathways result in increased turnover of epithelial cells and compromised barrier function. The assessment of the literature suggests that immunopathogenic mechanisms, such as tumor nec

Cureus. 2024 Sep 3;16(9):e68510. doi: 10.7759/cureus.68510. eCollection 2024 Sep. ABSTRACT Objective In this study, we aimed to investigate the correlation between the clinical diagnosis, histological diagnosis, and patch test positivity among patients with foot dermatoses receiving treatment at the Department of Dermatology, MES Medical College, Perinthalmanna. Methodology A hospital-based cross-sectional observational diagnostic evaluation was carried out from January 1, 2019, to December 31,

World J Cardiol. 2024 Sep 26;16(9):546-549. doi: 10.4330/wjc.v16.i9.546. ABSTRACT Tumour immunotherapy represented by immune checkpoint inhibitors (ICIs) has greatly improved the overall prognosis of patients with malignant tumours, and is regarded as an important breakthrough in the field of medicine in recent years. ICIs have gradually become the core of tumour therapy and are increasingly used in the clinic. In order to achieve early clinical prediction and management of immune-related advers

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17470. Online ahead of print. NO ABSTRACT PMID:39349977 | DOI:10.1111/1346-8138.17470 Den ganzen Artikel lesen

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17469. Online ahead of print. NO ABSTRACT PMID:39349364 | DOI:10.1111/1346-8138.17469 Den ganzen Artikel lesen

Skin Res Technol. 2024 Oct;30(10):e70071. doi: 10.1111/srt.70071. ABSTRACT OBJECTIVES: Cold plasma has shown efficacy in various dermatological applications by reduces inflammatory responses and modulating cytokine expression. Therefore, this study aimed to investigate the therapeutic effects of cold plasma on psoriasis. METHODS: In psoriasis HaCaT cells with cold plasma, we confirmed the expression of inflammatory cytokines involved in psoriasis formation and MAPK pathway, cell cycle, and apopt

J Dermatol. 2024 Sep 30. doi: 10.1111/1346-8138.17481. Online ahead of print. NO ABSTRACT PMID:39349351 | DOI:10.1111/1346-8138.17481 Den ganzen Artikel lesen

Autoimmun Rev. 2024 Sep 28:103649. doi: 10.1016/j.autrev.2024.103649. Online ahead of print. ABSTRACT Tyk2 is a member of the JAK kinase family. It is an important mediator in pro-inflammatory signalling, implicated in both innate and adaptive immune system. Activation of Tyk2 is believed to be integral to cellular processes that contribute to the development and progression of autoimmune disorders. Selective targeting of Tyk2 may reduce the number of adverse events as compared to non-selective

Adv Ther. 2024 Sep 30. doi: 10.1007/s12325-024-02976-w. Online ahead of print. ABSTRACT INTRODUCTION: Special body area involvement is common in psoriasis and can be challenging to treat. We investigated the efficacy of ixekizumab (IXE) in Chinese patients with moderate-to-severe psoriasis and fingernail, scalp, or palmoplantar involvement. METHODS: A post-hoc sub-analysis of a phase 3 trial, in which patients were randomized to receive placebo, IXE 80 mg every 2 (IXE Q2W) or 4 (IXE Q4W) weeks.

Psoriasis (Auckl). 2024 Sep 23;14:115-120. doi: 10.2147/PTT.S490982. eCollection 2024. ABSTRACT The use of antiangiogenic and antiresorptive medications, particularly in patients with cancer or osteoporosis, can lead to osteonecrosis of the jaw following tooth extraction, trauma or arising spontaneously- A condition known as medication-related osteonecrosis of the jaw (MRONJ). In this article, we present a unique case of MRONJ in a patient with no history of antiresorptive or antiangiogenic drug

Psoriasis (Auckl). 2024 Sep 23;14:103-114. doi: 10.2147/PTT.S484609. eCollection 2024. ABSTRACT PURPOSE Tobacco smoking and alcohol drinking are positively associated with psoriasis prevalence and disease severity. Researches focusing on the influence of smoking and drinking on the treatment efficacy of psoriasis are still limited, especially their interaction effect. This study aims to explore the interactive effects of smoking and drinking on the treatment efficacy in psoriasis patients. PATIE

Cureus. 2024 Aug 28;16(8):e68037. doi: 10.7759/cureus.68037. eCollection 2024 Aug. ABSTRACT Introduction Psoriasis is a chronic, recurrent inflammatory skin condition that affects 1-3% of the global population. Increasing evidence suggests a higher prevalence of metabolic syndrome (MetS) among individuals with psoriasis. This study aims to investigate the prevalence of MetS in patients with psoriasis and compare the findings with existing literature. Methods This cross-sectional, hospital-based

Clin Cosmet Investig Dermatol. 2024 Sep 23;17:2111-2115. doi: 10.2147/CCID.S482555. eCollection 2024. ABSTRACT The patient, a 77-year-old Asian male presented with herpes zoster in the left lumbar and abdominal regions 9 weeks before presentation. The infection dried up after 2 weeks but was followed by an erythematous scaly rash in the same region with left-sided abdominal elevation. Pathological examination revealed continuous parakeratosis and Munro microabscesses. Abdominal computer tomograp

J Inflamm Res. 2024 Sep 24;17:6707-6721. doi: 10.2147/JIR.S472338. eCollection 2024. ABSTRACT PURPOSE: Recent studies have shown that novel biologics may provide significant clinical benefits for patients with generalized pustular psoriasis (GPP). Ustekinumab and secukinumab have been approved in Japan for GPP treatment in adult patients. However, the differences in efficacy and safety of these two drugs in GPP are not known. AIM: Based on the genetic background, we aimed to compare the efficacy

Front Biosci (Landmark Ed). 2024 Aug 30;29(9):311. doi: 10.31083/j.fbl2909311. ABSTRACT BACKGROUND: Psoriasis is a common, chronic, and multifactorial inflammatory cutaneous disorder that involves genetic and epigenetic factors. N6-methyladenosine methylation (m6A) is the most prevalent RNA modification implicated in various diseases; however, its role in psoriasis still needs to be further explored. We aimed to explore the mechanisms underlying the effects of m6A in psoriasis pathogenesis, prom

Am J Psychother. 2024 Sep 30:appipsychotherapy20230061. doi: 10.1176/appi.psychotherapy.20230061. Online ahead of print. ABSTRACT Epigenetic modifications play a pivotal role in the regulation of gene expression and cell function, offering potential markers of disease states and therapeutic outcomes. Recent advancements in neuroscience have spurred interest in studying the epigenetic underpinnings of psychosomatic medicine. This review presents a new perspective on the role of epigenetic regulat

Br J Dermatol. 2024 Sep 30:ljae370. doi: 10.1093/bjd/ljae370. Online ahead of print. NO ABSTRACT PMID:39344069 | DOI:10.1093/bjd/ljae370 Den ganzen Artikel lesen

Sci Rep. 2024 Sep 2;14(1):20320. doi: 10.1038/s41598-024-71340-3. ABSTRACT Asynchronous teledermatology (TD) has shown promise in improving access to dermatological care, yet studies reveal varied methodologies and results. This study aimed to design a mobile app using the store-and-forward model, marking a pioneering effort in Iran to facilitate written documentation of patient history and skin lesion imagery for accurate diagnosis. Conducted from July 2022 to July 2023, this study involved the

Best Pract Res Clin Rheumatol. 2024 Sep 1:101982. doi: 10.1016/j.berh.2024.101982. Online ahead of print. ABSTRACT Spondyloarthropathies (SpA), including ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have been shown to have a substantial genetic predisposition based on heritability estimates derived from family studies and genome-wide association studies (GWAS). GWAS have uncovered numerous genetic loci associated with susceptibility to SpA, with significant associations to human le

J Am Acad Dermatol. 2024 Aug 31:S0190-9622(24)02759-2. doi: 10.1016/j.jaad.2024.08.051. Online ahead of print. ABSTRACT BACKGROUND: Nail diseases are often associated with significant physical and psychosocial burden, but diagnosis is challenging due to non-specific clinical and histological findings. Nail fold capillaroscopy has been studied for diagnosis of systemic diseases, but studies on nail diseases are lacking. OBJECTIVE: Our objectives were to characterize and compare capillary changes

Clin Dermatol. 2024 Aug 31:S0738-081X(24)00150-0. doi: 10.1016/j.clindermatol.2024.08.010. Online ahead of print. ABSTRACT Dr. Benjamin Bender (1908-1996) was a longtime Clinical Professor of Dermatology at the State University of New York Downstate College of Medicine. Some 45 years ago, he coined the eponym Bender sign, which describes the discovery of cutaneous diseases that involve the gluteal cleft by having patients bend over and then manually separating the buttocks. Bender's eponym was c