Aus Pubmed

J Low Genit Tract Dis. 2024 Sep 2. doi: 10.1097/LGT.0000000000000839. Online ahead of print. ABSTRACT OBJECTIVE: We present a case series of severe vulvovaginal candidiasis in postmenopausal women using sodium-glucose cotransporter-2 inhibitor (SGLT2i) medications for the management of their diabetes mellitus. MATERIALS AND METHODS: Twenty-four cases from a private vulvovaginal specialist clinic are described. RESULTS: All 24 patients were referred with severe and persistent vulvar pruritus, pai

Front Med (Lausanne). 2024 Aug 16;11:1455953. doi: 10.3389/fmed.2024.1455953. eCollection 2024. ABSTRACT INTRODUCTION: Psoriasis, a chronic inflammatory skin disease, is believed to be influenced by both genetic and environmental factors. Despite this understanding, the clinical epidemiological status of psoriasis patients with a family history of the disease remains uncertain. METHODS: In this study, we participated in a multicenter observational epidemiological study involved over 1,000 hospit

Drug Des Devel Ther. 2024 Aug 28;18:3871-3889. doi: 10.2147/DDDT.S467066. eCollection 2024. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory disease. Qingre Lishi Decoction (QRLSD) has achieved great clinical effect in the treatment of psoriasis. However, the potential bioactive components and the mechanisms are yet unclear. AIM: To analyze the serum parameters of rats fed with QRLSD, screen out the active components of QRLSD, and explore the potential targets and pathwa

Int J Mol Med. 2024 Nov;54(5):91. doi: 10.3892/ijmm.2024.5415. Epub 2024 Sep 2. ABSTRACT Psoriasis is a chronic inflammatory skin condition with numerous causes, including genetic, immunological and infectious factors. The course of psoriasis is long and recurrence is common; pathogenesis is not completely understood. However, there is an association between advancement of psoriasis and aberrant microRNA (miR or miRNA)‑155 expression. Through bioinformatics, the present study aimed to analyze th

Rheumatol Int. 2024 Sep 2. doi: 10.1007/s00296-024-05687-1. Online ahead of print. NO ABSTRACT PMID:39218830 | DOI:10.1007/s00296-024-05687-1 Den ganzen Artikel lesen

Skin Res Technol. 2024 Sep;30(9):e70035. doi: 10.1111/srt.70035. ABSTRACT BACKGROUND: Atopic dermatitis (AD), psoriasis (PSO), rosacea, and other related immune skin diseases are affected by multiple complex factors such as genetic and microbial components. This research investigates the causal relationships between specific skin microbiota and these diseases by using Mendelian randomization (MR), and Bayesian weighted Mendelian randomization (BWMR). METHODS: We utilized genome-wide association

Dermatol Ther (Heidelb). 2024 Jul 3. doi: 10.1007/s13555-024-01206-z. Online ahead of print. ABSTRACT INTRODUCTION: Diagnosis of persistent erythematous, scaly patches, or plaques can be complex since psoriasis (Ps), eczematous dermatitis (ED), and mycosis fungoides (MF) can be considered. Dermoscopy, which is a noninvasive diagnostic tool, is commonly used to examine blood vessels, scales, and background color; however, research on hair shaft evaluation in inflammatory dermatoses remains scarce

J Dermatol Sci. 2024 Jun 18:S0923-1811(24)00132-4. doi: 10.1016/j.jdermsci.2024.06.002. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is an inflammatory skin disease with unclear pathogenesis and unmet therapeutic needs. OBJECTIVE: To investigate the role of senescent CD4+ T cells in psoriatic lesion formation and explore the application of senolytics in treating psoriasis. METHODS: We explored the expression levels of p16INK4a and p21, classical markers of cellular senescence, in CD4+ T

J Eur Acad Dermatol Venereol. 2024 Jun 21. doi: 10.1111/jdv.20192. Online ahead of print. NO ABSTRACT PMID:38959368 | DOI:10.1111/jdv.20192 Den ganzen Artikel lesen

Sci Adv. 2024 Jul 5;10(27):eado2365. doi: 10.1126/sciadv.ado2365. Epub 2024 Jul 3. ABSTRACT Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease with a poorly understood pathogenesis. Through a molecularly driven precision medicine approach and an extensive mechanistic pathway analysis in PRP skin samples, compared to psoriasis, atopic dermatitis, healed PRP, and healthy controls, we identified IL-1β as a key mediator, orchestrating an NF-κB-mediated IL-1β-CCL20 axis, including act

J Invest Dermatol. 2024 Jul 2:S0022-202X(24)01731-7. doi: 10.1016/j.jid.2024.05.015. Online ahead of print. ABSTRACT The definition of paradoxical psoriasis (PP) encompasses 2 main scenarios, namely, (i) new-onset psoriasis in patients treated for a different disease and (ii) worsening as well as phenotypical change of pre-existing psoriasis. Originally restricted to the appearance of an untoward psoriasiform reaction under TNF inhibitors, the term has gained new meaning, with the progressive ob

JAAD Int. 2024 May 9;16:119-121. doi: 10.1016/j.jdin.2024.03.018. eCollection 2024 Sep. NO ABSTRACT PMID:38957840 | PMC:PMC11217681 | DOI:10.1016/j.jdin.2024.03.018 Den ganzen Artikel lesen

Dermatol Reports. 2023 Oct 16;16(2):9854. doi: 10.4081/dr.2023.9854. eCollection 2024 Jun 14. ABSTRACT Psoriasis is a chronic inflammatory skin disease that affects people all over the world. It is linked to the HLA-Cw6 allele, which is more common in Caucasians than in Asians and varies across ethnic groups. We investigated the association between the disease severity and the onset age of HLA-Cw6 prevalence in Vietnamese psoriasis patients. In 121 psoriasis patients and 30 healthy controls, we

Dermatol Reports. 2023 Aug 29;16(2):9778. doi: 10.4081/dr.2023.9778. eCollection 2024 Jun 14. ABSTRACT Few studies have examined pruritus in elderly patients, a common dermatological condition. The study examines pruritus prevalence and characteristics in elderly patients referred to the Dermatology Unit, at Genoa's Galliera Hospital. The demographic characteristics of all Outpatient Clinic patients with any skin condition were examined, focusing on pruritus patients over 65. Pruritus was presen

Curr Drug Deliv. 2024 Jul 2. doi: 10.2174/0115672018246645231019131748. Online ahead of print. ABSTRACT BACKGROUND: The therapeutic effect of NS oil in mild to moderate psoriasis is limited owing to low play load of thymoquinone ( < 15 %w/w), irritation, dripping, low viscosity and thus, less contact time on the lesions. AIMS: This study aimed at developing and characterizing the ethanolic vesicular hydrogel system of Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-p

Sci Rep. 2024 Jul 2;14(1):15121. doi: 10.1038/s41598-024-65902-8. ABSTRACT Interleukin-17A therapeutic inhibitors are among the most effective treatment methods for moderate-to-severe plaque psoriasis (PP). Reflectance confocal microscopy is a non-invasive imaging technique already documented to be beneficial in evaluating the follow-up of PP under treatment with topical actives and phototherapy. This study aimed to assess the epidermal and dermal changes associated with psoriasis and its treatm

J Immunol. 2024 Jun 10:ji2300752. doi: 10.4049/jimmunol.2300752. Online ahead of print. ABSTRACT Psoriasis is a common inflammatory skin disorder with no cure. Mesenchymal stem cells (MSCs) have immunomodulatory properties for psoriasis, but the therapeutic efficacies varied, and the molecular mechanisms were unknown. In this study, we improved the efficacy by enhancing the immunomodulatory effects of umbilical cord-derived MSCs (UC-MSCs). UC-MSCs stimulated by TNF-α and IFN-γ exhibited a better

Appl Opt. 2024 May 20;63(15):4131-4143. doi: 10.1364/AO.520397. ABSTRACT Planar X e B r ∗ and X e C l ∗ excilamps emitting noncoherent narrowband UVB light (280-315 nm) are now widely used to cure psoriasis and vitiligo as well as to improve vitamin D synthesis. The two-dimensional integral formula has been deducted in this study, which is a good method and has great practical significance to calculate the total radiant power and assess the energy efficiency of a planar UV lamp. The measured rad

Transl Androl Urol. 2024 May 31;13(5):748-758. doi: 10.21037/tau-24-10. Epub 2024 May 28. ABSTRACT BACKGROUND: The association between psoriasis and erectile dysfunction (ED) is currently inconsistent in epidemiological and observational studies and the causal relationship between them has not been established. The aim of our study is to explore the potential genetic association between ED and psoriasis. METHODS: We explored the putative causality between psoriasis and ED by bidirectional Mendel

Theranostics. 2024 May 27;14(8):3339-3357. doi: 10.7150/thno.93764. eCollection 2024. ABSTRACT Rationale: Skin cells actively metabolize nutrients to ensure cell proliferation and differentiation. Psoriasis is an immune-disorder-related skin disease with hyperproliferation in epidermal keratinocytes and is increasingly recognized to be associated with metabolic disturbance. However, the metabolic adaptations and underlying mechanisms of epidermal hyperproliferation in psoriatic skin remain large

Clin Epidemiol. 2024 Jun 4;16:395-407. doi: 10.2147/CLEP.S445120. eCollection 2024. ABSTRACT PURPOSE: This research aimed to develop and validate a META-algorithm combining individual immune-mediated inflammatory disease (IMID)-specific algorithms to identify the exact IMID indications for incident biological drug users from claims data within the context of the Italian VALORE project. METHODS AND PATIENTS: All subjects with at least one dispensing of TNF-alpha inhibitors, anti-interleukin agent

Int J Womens Dermatol. 2024 Jun 7;10(2):e152. doi: 10.1097/JW9.0000000000000152. eCollection 2024 Jun. ABSTRACT BACKGROUND: In some hidradenitis suppurativa (HS) clinical trial study arms, there is an unexpected decline in efficacy between the penultimate visit and the prespecified primary endpoint week, which we have termed a "wobble." OBJECTIVE: We aimed to establish how often study arms in HS programs wobble. METHODS: In a retrospective review, we identified HS clinical trials listed on Clini

Cureus. 2024 May 10;16(5):e60051. doi: 10.7759/cureus.60051. eCollection 2024 May. ABSTRACT Psoriasis is a chronic dermatologic condition that oftentimes requires extensive trial and error with various topical and systemic therapies until improvement is achieved. Interleukin-17 inhibitors (IL-17i), such as secukinumab, have been utilized in the treatment of psoriasis due to their mechanism of action. As with all medications, IL-17 inhibitors possess adverse effects, the most common being infecti

Cureus. 2024 May 9;16(5):e60008. doi: 10.7759/cureus.60008. eCollection 2024 May. ABSTRACT Methotrexate is an anti-inflammatory and immunomodulatory drug, widely used for moderate to severe psoriasis and other rheumatological conditions such as rheumatoid arthritis, besides some types of malignancies. Side effects are more prevalent in high acute doses but can also be seen in low-dose chronic use, especially in cases of drug-dosing errors. Possible symptoms of toxicity include gastrointestinal,

Cureus. 2024 May 8;16(5):e59878. doi: 10.7759/cureus.59878. eCollection 2024 May. ABSTRACT Background Psoriasis is a papulosquamous disease with variable morphology, distribution, severity, and course. Chronic plaque psoriasis, or psoriasis vulgaris, is the most common form of psoriasis. Present available preparations for mild to moderate chronic plaque psoriasis for topical use are local corticosteroids, coal tar, dithranol, tazarotene, calcipotriol, tapinarof, and calcineurin inhibitors. Howev