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Aging (Albany NY). 2024 Jun 6;16. doi: 10.18632/aging.205902. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is a complex and recurrent chronic inflammatory skin disease, and the abnormal proliferation of keratinocytes plays a crucial role in the pathogenesis of psoriasis. Long non-coding RNAs (lncRNAs) play an indispensable role in regulating cellular functions. This research aims to explore the potential impact of lncRNA MIR181A2HG on the regulation of keratinocyte proliferation. METHOD

Arch Dermatol Res. 2024 Jun 8;316(7):365. doi: 10.1007/s00403-024-03036-7. ABSTRACT Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfactory results in the treatment of nail psoriasis.The aim of the study was to assess the clinical and ultrasonographic efficacy of long-pulsed 1

J Pers Med. 2024 Apr 17;14(4):427. doi: 10.3390/jpm14040427. ABSTRACT (1) Background: Although the association between psoriasis and atopic dermatitis (AD) is reported in the literature, scarce data are known about the efficacy of biologic therapy (including TNF and IL-17 inhibitors) in patients with psoriatic arthritis (PsA) and concomitant AD. (2) Objective: We aimed to explore AD in patients with PsA undergoing biologics for their active disease, focusing on prevalence and clinical and potent

Int Immunopharmacol. 2024 May 16;134:112225. doi: 10.1016/j.intimp.2024.112225. Online ahead of print. ABSTRACT Itolizumab is a humanized monoclonal antibody that selectively targets the CD6-ALCAM pathway. This article reports on the safety and efficacy of itolizumab in the treatment of moderate-to-severe plaque psoriasis in a clinical study conducted in Cuba in the setting of an expanded-access program (EAP). The study included 84 patients who had previously received conventional anti-psoriatic

Antioxidants (Basel). 2024 Mar 30;13(4):425. doi: 10.3390/antiox13040425. ABSTRACT Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also k

World J Cardiol. 2024 Sep 26;16(9):546-549. doi: 10.4330/wjc.v16.i9.546. ABSTRACT Tumour immunotherapy represented by immune checkpoint inhibitors (ICIs) has greatly improved the overall prognosis of patients with malignant tumours, and is regarded as an important breakthrough in the field of medicine in recent years. ICIs have gradually become the core of tumour therapy and are increasingly used in the clinic. In order to achieve early clinical prediction and management of immune-related advers

Mol Biol Rep. 2024 May 10;51(1):635. doi: 10.1007/s11033-024-09337-4. ABSTRACT BACKGROUND: Psoriasis, a chronic inflammatory skin disease, is increasingly effectively managed with the targeted immunotherapy; however, long-term immunotherapy carries health risks, and loss of response. Therefore, we need to develop the alternative treatment strategies. Mesenchymal stem/stromal cell (M.S.C.) exosomes stand out for their remarkable immunomodulatory properties, gaining widespread recognition. This st

Cell Mol Biol Lett. 2025 Jan 17;30(1):7. doi: 10.1186/s11658-025-00685-y. ABSTRACT The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. Phospholipids are subject to continuous transformation, including enzymatic hydrol

J Prosthodont Res. 2025 Jan 3. doi: 10.2186/jpr.JPR_D_24_00061. Online ahead of print. ABSTRACT PURPOSE: Psoriasis is a complex, chronic inflammatory keratosis of unclear origin that is challenging to treat. In patients with psoriasis suspected of having metal allergies, the removal of oral metallic prostheses contributes to the alleviation of psoriasis symptoms. However, the relationship and mechanism of the metal removal effect and improvement in psoriasis symptoms in patients with metal aller

Skinmed. 2024 Oct 22;22(5):387-389. eCollection 2024. ABSTRACT A 79-year-old woman with psoriasis presented to the emergency department with new-onset eruptions on the trunk, extremities, and oral mucosa for 8-9 days. For psoriasis, she had been taking 15 mg of methotrexate weekly for over 18 years, and had discontinued folic acid a few months prior to this. PMID:39433528 Den ganzen Artikel lesen

Acta Pharm Sin B. 2024 Dec;14(12):5161-5180. doi: 10.1016/j.apsb.2024.08.013. Epub 2024 Aug 22. ABSTRACT Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding a viable resolution to the formidable barriers presented by the cutaneous interface. This review examines MNs as an advanced approach to enhancing dermatological pathology management. It explores the complex dermis structure and highlights the limitations of traditional transdermal methods, emphasizin

Int J Mol Med. 2024 Nov;54(5):91. doi: 10.3892/ijmm.2024.5415. Epub 2024 Sep 2. ABSTRACT Psoriasis is a chronic inflammatory skin condition with numerous causes, including genetic, immunological and infectious factors. The course of psoriasis is long and recurrence is common; pathogenesis is not completely understood. However, there is an association between advancement of psoriasis and aberrant microRNA (miR or miRNA)‑155 expression. Through bioinformatics, the present study aimed to analyze th

J Transl Autoimmun. 2024 Oct 2;9:100251. doi: 10.1016/j.jtauto.2024.100251. eCollection 2024 Dec. ABSTRACT BACKGROUND: Mitochondrial DNA plays a crucial role in the pathophysiology of autoimmune diseases (ADs). However, the association between mitochondrial DNA copy number (mtDNA-CN) and ADs risk is controversial. In this study, Mendelian randomization (MR) analysis and meta-analysis were performed using three sets of independent instrumental variables (IVs) to investigate the potential associat

Pharmaceutics. 2024 Oct 4;16(10):1295. doi: 10.3390/pharmaceutics16101295. ABSTRACT BACKGROUND/OBJECTIVES: Implementing model-informed precision dosing (MIPD) strategies guided by population pharmacokinetic/pharmacodynamic (PK/PD) models could enhance the management of inflammatory diseases such as psoriasis. However, the extent of individual experimental data gathered during MIPD significantly influences the uncertainty in estimating individual PK/PD parameters, affecting clinical dose selectio

Arch Dermatol Res. 2024 Jun 8;316(7):374. doi: 10.1007/s00403-024-03024-x. ABSTRACT The microbiome is intricately linked to the development of psoriasis, serving as both a potential cause and consequence of the psoriatic process. In recent years, there has been growing interest among psoriasis researchers in exploring how psoriasis treatments affect the skin and gut microbiome. However, a comprehensive evaluation of the impact of modern treatment approaches on the microbiome has yet to be conduc

Explore (NY). 2024 Dec 10;21(1):103098. doi: 10.1016/j.explore.2024.103098. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a chronic inflammatory skin disease that can present in various phenotypes, with the most common form being plaque psoriasis. Currently, no type of psoriasis can be cured, and existing treatment options are associated with certain safety concerns. In recent years, traditional Chinese medicine has achieved great results in treating psoriasis. Cupping therapy is a

Bioorg Chem. 2024 Apr 6;147:107351. doi: 10.1016/j.bioorg.2024.107351. Online ahead of print. ABSTRACT Eleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppre

J Am Acad Dermatol. 2024 Aug 31:S0190-9622(24)02759-2. doi: 10.1016/j.jaad.2024.08.051. Online ahead of print. ABSTRACT BACKGROUND: Nail diseases are often associated with significant physical and psychosocial burden, but diagnosis is challenging due to non-specific clinical and histological findings. Nail fold capillaroscopy has been studied for diagnosis of systemic diseases, but studies on nail diseases are lacking. OBJECTIVE: Our objectives were to characterize and compare capillary changes

J Am Acad Dermatol. 2024 Apr 10:S0190-9622(24)00626-1. doi: 10.1016/j.jaad.2024.02.062. Online ahead of print. NO ABSTRACT PMID:38608866 | DOI:10.1016/j.jaad.2024.02.062 Den ganzen Artikel lesen

Life (Basel). 2024 Apr 10;14(4):492. doi: 10.3390/life14040492. ABSTRACT Skin conditions are numerous and often have a major impact on patients' quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial products that can induce various side effects, especially with long-term use, which is why researchers are studying alternatives, especially biologically active natural products. Three products

Cutis. 2024 Feb;113(2):54-55. doi: 10.12788/cutis.0950. NO ABSTRACT PMID:38593093 | DOI:10.12788/cutis.0950 Den ganzen Artikel lesen

Curr Drug Deliv. 2024 Jul 2. doi: 10.2174/0115672018246645231019131748. Online ahead of print. ABSTRACT BACKGROUND: The therapeutic effect of NS oil in mild to moderate psoriasis is limited owing to low play load of thymoquinone ( < 15 %w/w), irritation, dripping, low viscosity and thus, less contact time on the lesions. AIMS: This study aimed at developing and characterizing the ethanolic vesicular hydrogel system of Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-p

J Multidiscip Healthc. 2024 May 27;17:2635-2646. doi: 10.2147/JMDH.S432820. eCollection 2024. ABSTRACT PURPOSE: Immune-mediated inflammatory diseases (eg, axial spondylitis, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and hidradenitis suppurativa) are common diseases that exert an extensive effect on the health-related quality of life, particularly when multiple concomitant conditions are present. Previous reports indicate that the traditional siloed approach to care can

Dermatol Ther (Heidelb). 2024 May 10. doi: 10.1007/s13555-024-01170-8. Online ahead of print. ABSTRACT INTRODUCTION: There are several treatment options for plaque psoriasis (PsO), but uncertainty remains around the optimal sequencing of treatments. The aims of this study were to investigate how adopting a best-treatment-first treatment sequence impacts patient outcomes and healthcare systems and to quantify the cost of treatment failure to the healthcare system. METHODS: A 3-year state-transiti

JAAD Int. 2024 Nov 14;19:12-20. doi: 10.1016/j.jdin.2024.09.015. eCollection 2025 Apr. ABSTRACT BACKGROUND: There is limited evidence on treating psoriasis patients with skin of color (SOC), contributing to disparities in accessing appropriate care for these patients. OBJECTIVES: This study aimed to develop consensus statements defining SOC terminology and addressing needs to optimize the clinical management of psoriasis in patients with SOC. METHODS: Using the modified Delphi methodology 16 Can