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Cureus. 2024 May 9;16(5):e59969. doi: 10.7759/cureus.59969. eCollection 2024 May. ABSTRACT Background Psoriasis is a chronic inflammatory skin disease with multiple organ manifestations such as arthritis and cardiovascular diseases. While recent therapeutic advancements in systemic biologics have demonstrated efficacy against psoriasis, a complete cure has not been achieved and patients require lifelong treatment to control symptoms. Objective This study aimed to clarify the clinical characteris

Arch Dermatol Res. 2024 Jun 8;316(7):374. doi: 10.1007/s00403-024-03024-x. ABSTRACT The microbiome is intricately linked to the development of psoriasis, serving as both a potential cause and consequence of the psoriatic process. In recent years, there has been growing interest among psoriasis researchers in exploring how psoriasis treatments affect the skin and gut microbiome. However, a comprehensive evaluation of the impact of modern treatment approaches on the microbiome has yet to be conduc

Arch Dermatol Res. 2024 Jun 8;316(7):362. doi: 10.1007/s00403-024-03122-w. ABSTRACT Secukinumab is a fully human IgG1 antibody that selectively binds to and neutralizes the proinflammatory cytokine interleukin-17A. Secukinumab is an effective and well-tolerated treatment for plaque psoriasis. There is a limited real-word evidence for dose optimisation of secukinumab based on clinical response. PURE is a multi-national, prospective, observational study in patients with moderate to severe chronic

Arch Dermatol Res. 2024 Jun 8;316(7):365. doi: 10.1007/s00403-024-03036-7. ABSTRACT Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfactory results in the treatment of nail psoriasis.The aim of the study was to assess the clinical and ultrasonographic efficacy of long-pulsed 1

Arch Dermatol Res. 2024 Jun 8;316(7):369. doi: 10.1007/s00403-024-03074-1. NO ABSTRACT PMID:38850288 | DOI:10.1007/s00403-024-03074-1 Den ganzen Artikel lesen

Arch Dermatol Res. 2024 Jun 8;316(7):363. doi: 10.1007/s00403-024-03051-8. ABSTRACT Streptococcal infections may contribute to psoriasis development, and antistreptococcal treatments are considered potential therapies, but their effectiveness remains uncertain due to limited systematic evidence. Our objective was to analyze antistreptococcal therapies' effectiveness in improving psoriasis. We conducted a systematic review following PRISMA guidelines, evaluating antistreptococcal treatment effica

Arch Dermatol Res. 2024 Jun 7;316(7):347. doi: 10.1007/s00403-024-03147-1. NO ABSTRACT PMID:38849678 | DOI:10.1007/s00403-024-03147-1 Den ganzen Artikel lesen

J Rheumatol. 2024 Jun 7:jrheum.2024-0330. doi: 10.3899/jrheum.2024-0330. Online ahead of print. ABSTRACT The 78th Annual Meeting of the Canadian Rheumatology Association was held at the RBC Convention Centre in Winnipeg, Manitoba, Canada, and virtually on February 28-March 2, 2024. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2024 Award Winners: Distinguished Rheumatologist, John M. Esdaile; Dis

Aging (Albany NY). 2024 Jun 6;16. doi: 10.18632/aging.205902. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is a complex and recurrent chronic inflammatory skin disease, and the abnormal proliferation of keratinocytes plays a crucial role in the pathogenesis of psoriasis. Long non-coding RNAs (lncRNAs) play an indispensable role in regulating cellular functions. This research aims to explore the potential impact of lncRNA MIR181A2HG on the regulation of keratinocyte proliferation. METHOD

Rheumatol Ther. 2024 Jun 7. doi: 10.1007/s40744-024-00680-3. Online ahead of print. ABSTRACT INTRODUCTION: Biologic therapies are licensed for both psoriasis (PsO) and psoriatic arthritis (PsA) with some electronic medical record data suggest that IL (Interleukin)-23 blockers might be more protective in PsA prevention than TNF blockers; however, the findings have been inconsistent. Higher Psoriasis Area and Severity Index (PASI) scores have also been linked to an increased PsA risk. To clarify t

Arch Dermatol Res. 2024 Jun 7;316(7):340. doi: 10.1007/s00403-024-03075-0. ABSTRACT Psoriasis (PsO) is a chronic inflammatory skin condition, often accompanied by psoriatic arthritis (PsA) and linked to various comorbidities and increased mortality rates. This study aimed to explore the relationship between PsO and accelerated biological aging, specifically focusing on epigenetic DNA methylation clocks. Using a matched case-control design, 20 PsO cases were selected along with age, race, and sex

Int J Dermatol. 2024 Jun 7. doi: 10.1111/ijd.17303. Online ahead of print. NO ABSTRACT PMID:38847446 | DOI:10.1111/ijd.17303 Den ganzen Artikel lesen

J Cutan Med Surg. 2024 Jun 7:12034754241260023. doi: 10.1177/12034754241260023. Online ahead of print. ABSTRACT There has been a call to action to enhance representation of non-white individuals in dermatology clinical trials. Investigations in differential response to treatment across populations are limited, particularly in conditions of commonality, impact, distinct presentation, and diagnosis in non-white participants, such as atopic dermatitis and psoriasis. This systematic review summarize

J Dermatol. 2024 Jun 7. doi: 10.1111/1346-8138.17313. Online ahead of print. ABSTRACT Nail psoriasis is a chronic condition characterized by nail dystrophy affecting the nail matrix and bed. The severity of nail psoriasis is commonly assessed using the Nail Psoriasis Severity Index (NAPSI), which evaluates the characteristics and extent of nail involvement. Although the NAPSI is numeric, reproducible, and simple, the assessment process is time-consuming and often challenging to use in real-world

J Dermatol. 2024 Jun 7. doi: 10.1111/1346-8138.17317. Online ahead of print. NO ABSTRACT PMID:38847289 | DOI:10.1111/1346-8138.17317 Den ganzen Artikel lesen

Front Immunol. 2024 May 23;15:1410540. doi: 10.3389/fimmu.2024.1410540. eCollection 2024. ABSTRACT Psoriasis is a common, life-long skin disease with a significant negative health and societal impact. Data on rates of disease control and treatment strategies are lacking in Central and Eastern European countries. We aimed to describe the real-world disease severity, control, and treatment strategies for psoriasis in patients from Central and Eastern European countries. CRYSTAL (EUPAS36459) was a

Dermatol Ther (Heidelb). 2024 Jun 3. doi: 10.1007/s13555-024-01167-3. Online ahead of print. NO ABSTRACT PMID:38831119 | DOI:10.1007/s13555-024-01167-3 Den ganzen Artikel lesen

Folia Biol (Praha). 2024;70(1):53-61. doi: 10.14712/fb2024070010053. ABSTRACT Psoriasis is a chronic non-contagious autoimmune disease. Gallic acid is a natural compound with potential health benefits, including antioxidant, anticancer, antiviral and antibacterial properties. Nevertheless, the influence of gallic acid on psoriasis has not been fully determined. This investigation aimed to discover the effect of gallic acid on psoriasis. Thirty-one pairs of psoriatic skin tissues and healthy adul

Ter Arkh. 2024 Jun 3;96(5):486-493. doi: 10.26442/00403660.2024.05.202704. ABSTRACT AIM: To study the frequency of hypogonadism (HG) in men with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and to evaluate the impact of HG on the course of RA and and concomitant diseases. MATERIALS AND METHODS: A single-stage continuous study included 170 men with RA, 57 men with AS and 85 men with PsA, who were hospitalized at the Nasonova Research Institute of Rheumatolo

Ter Arkh. 2024 Jun 3;96(5):479-485. doi: 10.26442/00403660.2024.05.202703. ABSTRACT AIM: To study and compare the clinical and imaging characteristics of psoriatic arthritis (PsA) in men and women. MATERIALS AND METHODS: The study included 956 PsA patients observed in the Russian register, 411 (43%) men and 545 (57%) women. The average age of men/women was 46.0±16.50/50.7±17.20 years (p<0.001), the duration of PsA was 9.9±6.4/10.3±7.6 years (p>0.05), the age at the time of PsA establishmen

Biomol Biomed. 2024 Apr 5. doi: 10.17305/bb.2024.10327. Online ahead of print. ABSTRACT Psoriasis is a globally prevalent chronic inflammatory skin disease. This study aimed to scrutinize the hub genes related to inflammation and potential molecular mechanisms in psoriasis. Utilizing mRNA expression profiles from public datasets GSE13355, GSE78097, and GSE14905, we set up a comprehensive analysis. Initially, we selected differentially expressed genes (DEGs) from psoriasis and control samples in

J Multidiscip Healthc. 2024 May 27;17:2635-2646. doi: 10.2147/JMDH.S432820. eCollection 2024. ABSTRACT PURPOSE: Immune-mediated inflammatory diseases (eg, axial spondylitis, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and hidradenitis suppurativa) are common diseases that exert an extensive effect on the health-related quality of life, particularly when multiple concomitant conditions are present. Previous reports indicate that the traditional siloed approach to care can

Acta Pharm Sin B. 2024 Jun;14(6):2646-2656. doi: 10.1016/j.apsb.2024.02.002. Epub 2024 Feb 20. ABSTRACT Tumor necrosis factor-α (TNF-α) is a promising target for inflammatory and autoimmune diseases. Spirohypertones A (1) and B (2), two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skeletons, were isolated from Hypericum patulum. The structures of 1 and 2 were confirmed through comprehensive spectroscopic analysis, single-crystal X-ray diffraction and electro

J Inflamm Res. 2024 May 28;17:3433-3448. doi: 10.2147/JIR.S467099. eCollection 2024. ABSTRACT As one of the most prevalent chronic inflammatory skin diseases, atopic dermatitis (AD) increasingly affects the aging population. Amid the ongoing global aging trend, it's essential to recognize the intricate relationship between AD and aging. This paper reviews existing knowledge, summarizing clinical observations of associations between AD and aging-related diseases in various systems, including endo

Front Physiol. 2024 May 7;15:1346971. doi: 10.3389/fphys.2024.1346971. eCollection 2024. ABSTRACT The epidermis, the outermost layer of the skin, serves as a protective barrier against external factors. Epidermal differentiation, a tightly regulated process essential for epidermal homeostasis, epidermal barrier formation and skin integrity maintenance, is orchestrated by several players, including signaling molecules, calcium gradient and junctional complexes such as gap junctions (GJs). GJ prot