J Invest Dermatol. 2021 Sep 23:S0022-202X(21)01409-3. doi: 10.1016/j.jid.2021.06.006. Online ahead of print.
ABSTRACT
Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflammation and disturbed keratinocyte differentiation, whereas stimulating autophagy might be a treatment option in inflammatory skin disease.
PMID:34565564 | DOI:10.1016/j.jid.2021.06.006