Janus kinase inhibitors : Indications, efficacy, uses, what should be taken into account?

Dermatologie (Heidelb). 2023 Dec 15. doi: 10.1007/s00105-023-05253-z. Online ahead of print.

ABSTRACT

Janus kinase inhibitors (JAKi) represent an immunomodulatory targeted therapy in various dermatoses. Throughout the past few years, JAKi have been approved for atopic dermatitis (AD), psoriasis vulgaris (PSO), alopecia areata (AA), and vitiligo. Further indications are currently under investigation. In this article the various systenic and topical JAKi used in dermatology are being presented regarding their efficacy and safety profile. A specific focus will be set on handling with safety issues including screening and control measures during treatment with JAKi. In addition, future use of JAKi in various dermatological diseases for which nowadays only insufficient therapy options are available is being discussed.

PMID:38100043 | DOI:10.1007/s00105-023-05253-z