Ausgewählte Studien

Front Immunol. 2024 Feb 16;15:1334844. doi: 10.3389/fimmu.2024.1334844. eCollection 2024. ABSTRACT Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on their potential contribution to disease development, we investigated the spatial transcriptome of sebaceous glands in psoriasis and atopic dermatitis patients across lesional and non-lesional human skin samples. Both atopic dermatitis and psoriasis sebaceous glands expressed genes

Figure 1 Study cohort and workflow. (A)… Figure 1 Study cohort and workflow. (A) The spatial transcriptomics dataset contains 6 lesional and… Figure …Den ganzen Artikel lesen

An Bras Dermatol. 2022 May 27:S0365-0596(22)00077-0. doi: 10.1016/j.abd.2021.10.002. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory dermatological disorder characterized by white scales and clearly demarcated erythematous plaques. The prevalence of psoriasis varies from country to country and can occur at any age, implying that ethnicity, environmental factors, and genetic background all play a role in its onset. According to the World Psoriasis Day Consortium, 125 million p

Dermatologie (Heidelb). 2023 Oct 12. doi: 10.1007/s00105-023-05235-1. Online ahead of print. NO ABSTRACT PMID:37823915 | DOI:10.1007/s00105-023-05235-1 Den ganzen Artikel lesen

J Dermatolog Treat. 2022 May 26:1-3. doi: 10.1080/09546634.2022.2079596. Online ahead of print. NO ABSTRACT PMID:35593480 | DOI:10.1080/09546634.2022.2079596 Den ganzen Artikel lesen

Objectives: To prospectively evaluate the effect of guselkumab through 48 weeks across various clinical outcomes in subgroups of patients with …Den ganzen Artikel lesen

LETTER TO THE EDITOR Systemic immune-inflammation biomarkers in psoriasis patients under interleukin 17A-inhibitor treatment Corresponding Author T. …Den ganzen Artikel lesen

JAMA Dermatol. 2022 Mar 16:e220455. doi: 10.1001/jamadermatol.2022.0455. Online ahead of print. ABSTRACT IMPORTANCE: Systemic treatments for atopic dermatitis are being evaluated primarily in placebo-controlled trials; network meta-analysis can provide relative efficacy and safety estimates for treatments that have not been compared head to head. OBJECTIVE: To compare reported measures of efficacy and assessments of safety in clinical trials of systemic treatments for atopic dermatitis in a livi

Plaque psoriasis is a chronic, immunemediated skin disease characterized by scaly, erythematous, pruritic plaques. The effects of psoriasis are often …Den ganzen Artikel lesen

REVIEW ARTICLE Corresponding Author R. Bissonnette Innovaderm Research Inc., Montreal, Quebec, Canada Robert Bissonnette, MD, Innovaderm Research, 3530 …Den ganzen Artikel lesen

Atherosclerosis. 2021 Oct;335:98-109. doi: 10.1016/j.atherosclerosis.2021.09.024. Epub 2021 Sep 23. ABSTRACT Over the past fifteen years, treatments using monoclonal antibodies specifically targeting cytokines have been developed to treat chronic inflammatory diseases, including rheumatoid arthritis or psoriasis, both associated with increased cardiovascular risk. The cardiovascular impact of these therapies allows us to validate the clinical relevance of the knowledge acquired from experimental

Publication date: Available online 9 October 2023Source: Clinics in DermatologyAuthor(s): Chibuzo Aguwa, Ndidi Enwereji, Sueheidi Santiago, Ashley …Den ganzen Artikel lesen

Dudics S, Langan D, Meka RR, Venkatesha SH, Berman BM, Che CT, Moudgil KD. Dudics S, et al. Int J Mol Sci. 2018 Aug 24;19(9):2508. doi: …Den ganzen Artikel lesen

Background: Few studies have used real-world data to investigate the association between biologic therapy survival and age at psoriasis onset or …Den ganzen Artikel lesen

LETTER TO THE EDITOR The cardiometabolic safety of interleukin 23 versus interleukin 17 inhibitors in psoriasis: A large-scale global cohort …Den ganzen Artikel lesen

Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship …Den ganzen Artikel lesen

Full text linksCite Display options Display options The better understanding of the immunopathogenesis of psoriasis has led to the development of highly …Den ganzen Artikel lesen

Our team explored the utility of unpaid versions of 3 artificial intelligence chatbots in offering patient-facing responses to questions about 5 …Den ganzen Artikel lesen

An acidogenic diet, by disrupting the blood pH equilibrium, can contribute to metabolic acidosis and lead to inflammation. Therefore, we hypothesized …Den ganzen Artikel lesen

Full text linksCite Display options Display options Background: Evening primrose oil (EPO), extracted from the seeds of Oenothera biennis, has gained …Den ganzen Artikel lesen

Plaque psoriasis is a common skin disease that affects about 125 million people worldwide. The condition is caused by an overactive immune system …Den ganzen Artikel lesen

Life (Basel). 2023 Feb 2;13(2):419. doi: 10.3390/life13020419. ABSTRACT Interleukin 17 (IL-17) is an effector cytokine that plays a key role in the pathogenesis of both psoriasis and metabolic-associated fatty liver disease (MAFLD), a condition that is more prevalent and severe in patients with psoriasis. In liver inflammation, IL-17 is mainly produced by CD4+ T (TH17) and CD8+ T cells (Tc17), although numerous other cells (macrophages, natural killer cells, neutrophils and Tγδ cells) also contr

Psoriasis and psoriatic arthritis are chronic inflammatory conditions that constitute a significant global health burden due to their prevalence and …Den ganzen Artikel lesen

Br J Dermatol. 2023 Jan 23;188(1):122-130. doi: 10.1093/bjd/ljac027. ABSTRACT BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects intertriginous skin. OBJECTIVES: To determine the extent of work ability and productivity impairment as a result of HS in Germany. METHODS: A prospective, multicentre, epidemiological, noninterventional study of patients with HS was conducted. Medical history, medical examination performed by dermatologists and patient-reported out

Photodermatol Photoimmunol Photomed. 2024 Jan;40(1):e12948. doi: 10.1111/phpp.12948. ABSTRACT BACKGROUND: Phototherapy is a mainstay to treat itchy conditions. However, only little is known about differences in the antipruritic effect of phototherapy amongst different skin conditions, phototypes and genders. METHODS: In this prospective, single-center study, we analyzed the effect of phototherapy on itch intensity and itch-related quality of life amongst these subgroups after a treatment duratio