Ausgewählte Studien

Int J Pharm. 2022 Apr 25;618:121693. doi: 10.1016/j.ijpharm.2022.121693. Epub 2022 Mar 21. ABSTRACT Psoriasis is a condition of the skin which involves scales, dry patches, and inflammation. Methotrexate (logP: -1.8, MW:454.44 g/mol) is administered orally or intravenously to treat psoriasis. The first-pass metabolism and systemic toxicity can be avoided by administration via skin. Topical and transdermal delivery of methotrexate using iontophoresis and microneedles, alone and in combination was

Z Gerontol Geriatr. 2022 Mar 21. doi: 10.1007/s00391-022-02020-y. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVE: Demographic change confers significance to healthcare management of chronic diseases like psoriasis. There are few studies on the care of older people with psoriasis, particularly for the nursing home setting. It was investigated whether the number of psoriasis patients with specialist contact changes before vs. after nursing home admission. MATERIAL AND METHODS: We analyze

Acta Derm Venereol. 2022 Mar 21. doi: 10.2340/actadv.v102.583. Online ahead of print. ABSTRACT Psoriasis is a chronic, systemic inflammatory disease that affects the skin, with a high impact on patients' quality of life. The aim of this study was to identify and determine the relative importance of unmet needs in the management of moderate-to-severe psoriasis in Spain, from a multi-stakeholder perspective. A mixed method-approach was used to collect information, design a questionnaire and a disc

Front Immunol. 2022 Mar 3;13:839945. doi: 10.3389/fimmu.2022.839945. eCollection 2022. ABSTRACT It has been well established that the etiopathogenesis of diverse autoimmune diseases is rooted in the autoreactive immune cells' excessively proliferative state and impaired apoptotic machinery. Survivin is an anti-apoptotic and mitotic factor that has sparked a considerable research interest in this field. Survivin overexpression has been shown to contribute significantly to the development of autoi

Actas Dermosifiliogr. 2022 Mar 12:S0001-7310(22)00212-5. doi: 10.1016/j.ad.2022.02.028. Online ahead of print. ABSTRACT OBJECTIVE: To analyze degree of implementation of recommendations on the management of psoriasis during preconception, pregnancy, postpartum, breastfeeding, and perinatal care published by the Psoriasis Working Group of the Spanish Academy of Dermatology and Venereology (AEDV). METHODS: We designed a structured online survey consisting of closed questions. A link was emailed to

JAMA Dermatol. 2022 Mar 16:e220455. doi: 10.1001/jamadermatol.2022.0455. Online ahead of print. ABSTRACT IMPORTANCE: Systemic treatments for atopic dermatitis are being evaluated primarily in placebo-controlled trials; network meta-analysis can provide relative efficacy and safety estimates for treatments that have not been compared head to head. OBJECTIVE: To compare reported measures of efficacy and assessments of safety in clinical trials of systemic treatments for atopic dermatitis in a livi

Int J Mol Sci. 2022 Feb 28;23(5):2649. doi: 10.3390/ijms23052649. ABSTRACT In the original publication [...]. PMID:35270045 | PMC:PMC8910060 | DOI:10.3390/ijms23052649 Den ganzen Artikel lesen

Pharm Res. 2022 Feb 16. doi: 10.1007/s11095-022-03190-5. Online ahead of print. ABSTRACT PURPOSE: To investigate in vitro transdermal delivery of tofacitinib citrate across human skin using microporation by microneedles and iontophoresis alone and in combination. METHODS: In vitro permeation studies were conducted using vertical Franz diffusion cells. Microneedles composed of polyvinyl alcohol and carboxymethyl cellulose were fabricated and successfully characterized using scanning electron micr

MMW Fortschr Med. 2022 Jan;164(1):27. doi: 10.1007/s15006-022-0698-1. NO ABSTRACT PMID:35043321 | DOI:10.1007/s15006-022-0698-1 Den ganzen Artikel lesen

J Dtsch Dermatol Ges. 2022 Jan;20(1):106-111. doi: 10.1111/ddg.14639_g. NO ABSTRACT PMID:35040576 | DOI:10.1111/ddg.14639_g Den ganzen Artikel lesen

Internist (Berl). 2022 Feb;63(2):135-142. doi: 10.1007/s00108-021-01248-x. Epub 2022 Jan 14. ABSTRACT Biologics are an integral part of modern strategies for treatment of rheumatoid arthritis (RA) and spondylarthritis (SpA), including psoriatic arthritis (PsA). Biologics are biotechnologically produced proteins that have inhibiting effects on humoral and cellular components of rheumatic inflammation. Substance classes used in rheumatology are tumor necrosis factor (TNF)-alpha, interleukin (IL)-1

Hautarzt. 2022 Jan 5. doi: 10.1007/s00105-021-04933-y. Online ahead of print. ABSTRACT Psoriasis vulgaris occurs with a prevalence of up to 2% in childhood and adolescence. In most cases, diagnosis can be made clinically. We report about a pediatric patient with psoriasis vulgaris who posed a diagnostic challenge due to uncharacteristic manifestation. The most important differential diagnoses of various forms of psoriasis vulgaris as well as actual treatment recommendations in childhood and adol

Z Rheumatol. 2021 Dec 23. doi: 10.1007/s00393-021-01139-4. Online ahead of print. ABSTRACT Since 2001 rheumatologists throughout Germany have been recruiting patients with rheumatoid arthritis into the biologics register (rheumatoid arthritis: observation of biologics treatment, RABBIT) to investigate the long-term safety and efficacy of modern antirheumatic treatment. Over the past 20 years more than 20,000 patients have been enrolled in the prospective cohort study. This article summarizes the

Br J Dermatol. 2021 Dec;185(6):e200-e213. doi: 10.1111/bjd.20787. ABSTRACT Linked Article: Maul et al. Br J Dermatol 2021; 185:1160-1168. Psoriasis is a chronic, scaly skin condition affecting about 2·5% of the population. It has a negative impact on people's quality of life, more so in women. It is usually treated with creams but is sometimes severe enough to need strong medicines, which are not always effective. This study examines differences between men and women in their responses to treatm

Dermatol Ther (Heidelb). 2021 Dec 15. doi: 10.1007/s13555-021-00658-x. Online ahead of print. ABSTRACT INTRODUCTION: Psoriasis is a systemic inflammatory disease characterised by pruritic skin lesions that impair quality of life (QOL). Long-Term Documentation of the Utilization of Apremilast in Patients with Plaque Psoriasis under Routine Conditions (LAPIS-PSO; ClinicalTrials.gov: NCT02626793) was a 52-week, prospective, multicentre, observational cohort study conducted in real-world dermatology

Hautarzt. 2021 Dec 14:1-4. doi: 10.1007/s00105-021-04931-0. Online ahead of print. ABSTRACT We present a clinical case of a patient with acutely exacerbated erythrodermic psoriasis vulgaris after symptomatic infection with SARS-CoV‑2 (severe acute respiratory syndrome coronavirus 2). Various factors are already known that can lead to an exacerbation of psoriasis, such as drugs or infections with, for example, streptococcus. An association between psoriasis and an infection with SARS-CoV‑2 has be

Int J Dermatol. 2021 Dec 12. doi: 10.1111/ijd.15989. Online ahead of print. ABSTRACT BACKGROUND: Rosacea is a common chronic skin condition, but data on its epidemiology and related comorbidities are scarce. OBJECTIVES: To analyze the prevalence and associated cutaneous comorbidities of rosacea in Germany. METHODS: Voluntary dermatological full-body examinations were conducted between 2001 and 2016 in more than 500 German companies by experienced dermatologists and documented electronically. Poi

Rheumatology (Oxford). 2021 Dec 13:keab901. doi: 10.1093/rheumatology/keab901. Online ahead of print. ABSTRACT OBJECTIVES: To compare demographic and clinical characteristics of patients with axial spondyloarthritis (axSpA) across geographic regions. METHODS: PROOF is an observational study that enrolled recently diagnosed (≤1 year) axSpA patients fulfilling the Assessment of SpondyloArthritis international Society classification criteria from rheumatology clinical practices in 29 countries acro

J Dtsch Dermatol Ges. 2021 Dec;19(12):1736-1745. doi: 10.1111/ddg.14606_g. ABSTRACT Hintergrund: Die Psoriasis gilt als unabhängiger kardiovaskulärer Risikofaktor und Treiber einer Atherogenese. Mikrovaskuläre Veränderungen in psoriatischen Plaques sind gut beschrieben, wohingegen Veränderungen außerhalb betroffener Hautareale kaum untersucht wurden. In dieser Studie wurden Nagelfalzkapillaren von Psoriasispatienten in nicht betroffener Haut systematisch untersucht. Patienten und Methodik: Prosp

J Dtsch Dermatol Ges. 2021 Dec;19(12):1709-1710. doi: 10.1111/ddg.14684_g. NO ABSTRACT PMID:34894178 | DOI:10.1111/ddg.14684_g Den ganzen Artikel lesen

J Crohns Colitis. 2021 Dec 3:jjab213. doi: 10.1093/ecco-jcc/jjab213. Online ahead of print. ABSTRACT BACKGROUND: Immunomediated adverse events (IAEs) are the most frequently reported infliximab-related adverse events. Combination therapy may reduce their incidence, although this strategy is not recommended in elderly patients. AIMS: To compare the rates of infliximab-related IAE and loss of response (LOR) in elderly and younger patients. METHODS: Adult patients in the ENEIDA registry who had rec

RMD Open. 2021 Dec;7(3):e001975. doi: 10.1136/rmdopen-2021-001975. ABSTRACT OBJECTIVES: This study aims to provide a comprehensive analysis of the age-dependent risk of psoriatic arthritis (PsA). For this purpose, it focuses on the varying incidences within the different age groups. METHODS: The data were collected as part of the morbidity-based risk adjustment of the statutory health insurance companies in Germany. This survey recorded the International Statistical Classification of Diseases an

Life (Basel). 2021 Oct 28;11(11):1151. doi: 10.3390/life11111151. ABSTRACT In psoriasis treatment, there is a high need to define meaningful endpoints and differences from the patient perspective to analyze patient-relevant differences of frequently used outcome methods for psoriasis under real-world conditions. A sample of 3116 patients from the German Psoriasis-Registry PsoBest was analyzed for clinical as well as patient-reported outcomes (PRO) after 3- and 6-month treatment. The parameters P

Dermatology. 2021 Nov 25:1-10. doi: 10.1159/000520290. Online ahead of print. ABSTRACT BACKGROUND Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis that significantly impairs physical function and quality of life (QoL). Prompt therapeutic intervention is crucial for limiting PsA progression and preventing disability. OBJECTIVES The aim of this study was to compare the efficacy of brodalumab versus ustekin-umab and the im

Hautarzt. 2021 Nov 25. doi: 10.1007/s00105-021-04913-2. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis (Pso) and atopic dermatitis (AD) are chronic skin diseases that result in significant physical and psychological impairment, financial burden, and loss of quality of life. According to previous data, there are regional differences in healthcare. OBJECTIVES: The aim was to analyse the epidemiology as well as the treatment of insured people with Pso and AD in Germany in a regional comparis