Ausgewählte Studien

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J Mol Med (Berl). 2023 Dec 21. doi: 10.1007/s00109-023-02406-4. Online ahead of print. ABSTRACT Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under different

Taylor Francis For many patients including those with psoriasis, scientific manuscripts comprising clinical outcomes including psoriasis area severity …Den ganzen Artikel lesen

J Dtsch Dermatol Ges. 2023 May;21(5):537-539. doi: 10.1111/ddg.15013_g. NO ABSTRACT PMID:37183749 | DOI:10.1111/ddg.15013_g Den ganzen Artikel lesen

Commun Biol. 2022 Nov 15;5(1):1250. doi: 10.1038/s42003-022-04179-x. ABSTRACT T-cell-driven immune responses are responsible for several autoimmune disorders, such as psoriasis vulgaris and rheumatoid arthritis. Identification of metabolic signatures in inflamed tissues is needed to facilitate novel and individualised therapeutic developments. Here we show the temporal metabolic dynamics of T-cell-driven inflammation characterised by nuclear magnetic resonance spectroscopy-based metabolomics, hi

Dermatology. 2022 Jun 13:1-11. doi: 10.1159/000524199. Online ahead of print. ABSTRACT BACKGROUND: Psoriasis is an immune-mediated protracted ailment that perturbs about 100 million people globally. Anti-interleukin (IL)-23 agents have a distinctive status of safety and clinical efficacy. Anti-IL-23 operatives have demonstrated therapeutic prominences in cases of psoriasis in preceding global research. However, arrays of adverse events have been associated with the anti-IL-23 agents in the remed

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, …Den ganzen Artikel lesen

Todberg T, Egeberg A, Zachariae C, Sørensen N, Pedersen O, Skov L. Todberg T, et al. Br J Dermatol. 2022 Jul;187(1):89-98. doi: 10.1111/bjd.21245. …Den ganzen Artikel lesen

Analysis of Online Communities' Needs Among Psoriasis Patients on Social MediaDen ganzen Artikel lesen

Front Pharmacol. 2021 Oct 11;12:674095. doi: 10.3389/fphar.2021.674095. eCollection 2021. ABSTRACT Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile oils from terrestrial plants showed impressive therapeutic effects against disorders of the skin, digestive system, lungs, liver, metabolism, and

Psoriasis is a chronic inflammatory disorder affecting over 100 million people, requires long-term therapy. Current treatments offer only symptomatic …Den ganzen Artikel lesen

Actas Dermosifiliogr. 2023 Nov 2:S0001-7310(23)00854-2. doi: 10.1016/j.ad.2023.10.022. Online ahead of print. ABSTRACT BACKGROUND: Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease characterised by recurrent or intermittent flares. Epidemiological and disease management data in Spain are limited. Our goal was to estimate the epidemiology of GPP, explore its management, and reach consensus on the current challenges faced in Spain. METHODS: An electronic survey wa

Nat Commun. 2023 Jan 9;14(1):116. doi: 10.1038/s41467-022-35741-0. ABSTRACT Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on suppression of autoantibody formation and thus treatments directly stabilizing keratinocyte adhesion would fulfill an unmet medical need. We here demonstrate that apremilast, a phosphodiesterase 4 inhibitor used in psoriasis, prevents skin blistering in pemphigus vulgaris

ORIGINAL ARTICLE Are interleukin 17 and interleukin 23 inhibitors associated with malignancies? – Insights from an international population-based study …Den ganzen Artikel lesen

Dtsch Med Wochenschr. 2024 Feb;149(3):102-105. doi: 10.1055/a-2199-1549. Epub 2024 Jan 23. ABSTRACT HISTORY AND CLINICAL FINDINGS: The 71-year-old patient reported long-standing inflammatory arthralgia due to psoriasis vulgaris. Therapy with methotrexate led to elevated liver values; the symptoms persisted under treatment with the TNFα inhibitor adalimumab. MEDICAL EXAMINATIONS: Using arthrosonography and MRI, a predominantly periarticular inflammatory pattern on the wrists, metacarpophalangea

Objectives: Referral of patients from dermatology to rheumatology practices due to psoriasis is unnecessary delayed. Many times musculoskeletal …Den ganzen Artikel lesen

Original Paper Background: Dermatologic patient education materials (PEMs) are often written above the national average seventh- to eighth-grade …Den ganzen Artikel lesen

Acta Derm Venereol . 2025 Jan 3;105:41221. doi: 10.2340/actadv.v105.41221 Hannah WECKER 1Technical University of Munich, TUM School of Medicine and …Den ganzen Artikel lesen

Acta Derm Venereol. 2025 Jan 3;105:adv41221. doi: 10.2340/actadv.v105.41221.ABSTRACTThe comorbidity cycle between psoriasis and addictions remains …Den ganzen Artikel lesen

Expert Rev Pharmacoecon Outcomes Res. 2022 Apr 25:1-13. doi: 10.1080/14737167.2022.2063842. Online ahead of print. ABSTRACT BACKGROUND: Multi-criteria decision analysis (MCDA) was proposed to surmount arbitrary clinical decisions in the field of biological therapies for psoriatic patients. At the same time, MCDA may further highlight the potential of bimekizumab for the treatment of moderate-to-severe psoriasis, compared to placebo, adalimumab, ustekinumab, secukinumab, and even ixekizumab and r

JAMA Dermatol. 2022 Apr 6:e220526. doi: 10.1001/jamadermatol.2022.0526. Online ahead of print. ABSTRACT IMPORTANCE: Four distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown. OBJECTIVE: To assess the frequency of 4 rosacea subtypes. DATA SOURCES: This systemic review and meta-analysis included a search of 2 databases, PubMed and Embase, from inception of the databases to November 2, 2021. The search was filt

Postgrad Med. 2021 Sep 6:1-4. doi: 10.1080/00325481.2021.1974689. Online ahead of print. ABSTRACT Alopecia Areata is an inflammatory and T cell-mediated autoimmune reaction against unknown autoantigen of hair follicles characterized by patchy, non-scarring loss of hair follicles in the anagen phase. Although its etiology is minimally understood, genetic susceptibility, autoimmunity and stress are thought to be causative factors. It occurs in episodic and recurrent patterns with an incidence rate

Ther Adv Musculoskelet Dis. 2023 Feb 7;15:1759720X221149965. doi: 10.1177/1759720X221149965. eCollection 2023. ABSTRACT BACKGROUND: Tofacitinib is a Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA) and has been investigated for psoriasis (PsO). OBJECTIVES: This post hoc analysis examined baseline cardiovascular (CV) disease risk and its association with the occurrence of major adverse cardiovascular events (MACE) and malignancies in tofacitinib-treated patients with PsA and

Clin Cosmet Investig Dermatol . 2024 Nov 9;17:2523–2531. doi: 10.2147/CCID.S492053 Yizi Jiang 1First Clinical Medical College, Guizhou University of …Den ganzen Artikel lesen

Rapid Communication|Articles in Press Academic & Personal: 24 hour online access • Corporate R&D Professionals: 24 hour online access Powered …Den ganzen Artikel lesen