Ausgewählte Studien

Dermatol Ther. 2021 Nov 24:e15231. doi: 10.1111/dth.15231. Online ahead of print. ABSTRACT BACKGROUND: Data on the effectiveness and safety of a drug in real-world clinical practice complement the evidence from clinical trials, which are carried out in a different setting. Little has been published on the effectiveness and safety of guselkumab in the treatment of psoriasis in clinical practice. OBJECTIVES: To assess the effectiveness and safety of guselkumab at 24 weeks in patients with moderate

BMJ Open. 2021 Nov 16;11(11):e048647. doi: 10.1136/bmjopen-2021-048647. ABSTRACT INTRODUCTION: Psoriatic arthritis (PsA) is an inflammatory disease characterised by synovitis, enthesitis, dactylitis and axial involvement. The prevalence of axial involvement ranges from 25% to 70% in this patient group. Treatment recommendations for axial PsA were mainly extrapolated from guidelines for axial spondyloarthritis, and the main treatment options are non-steroidal anti-inflammatory drugs and biologica

Hautarzt. 2021 Dec;72(12):1025-1038. doi: 10.1007/s00105-021-04907-0. Epub 2021 Nov 4. ABSTRACT Optoacoustic imaging (OAB) has developed steadily in recent years. By means of partly pulsed light, in a wide variety of wavelengths, different colour carriers (chromophores) are excited to form sound waves. These in turn are detected by the newly developed systems and converted into three-dimensional images by means of various algorithms. The technique is characterised by a good ratio between contras

Front Pharmacol. 2021 Oct 11;12:674095. doi: 10.3389/fphar.2021.674095. eCollection 2021. ABSTRACT Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile oils from terrestrial plants showed impressive therapeutic effects against disorders of the skin, digestive system, lungs, liver, metabolism, and

JAMA Netw Open. 2021 Oct 1;4(10):e2129639. doi: 10.1001/jamanetworkopen.2021.29639. ABSTRACT IMPORTANCE: Although tumor necrosis factor (TNF) inhibitors are widely prescribed globally because of their ability to ameliorate shared immune pathways across immune-mediated inflammatory diseases (IMIDs), the impact of COVID-19 among individuals with IMIDs who are receiving TNF inhibitors remains insufficiently understood. Objective To examine the association between the

J Dtsch Dermatol Ges. 2021 Oct;19(10):1451-1462. doi: 10.1111/ddg.14532_g. NO ABSTRACT PMID:34661361 | DOI:10.1111/ddg.14532_g Den ganzen Artikel lesen

J Dtsch Dermatol Ges. 2021 Oct;19(10):1463-1477. doi: 10.1111/ddg.14547_g. NO ABSTRACT PMID:34661349 | DOI:10.1111/ddg.14547_g Den ganzen Artikel lesen

MMW Fortschr Med. 2021 Oct;163(18):10. doi: 10.1007/s15006-021-0304-y. NO ABSTRACT PMID:34652640 | PMC:PMC8518277 | DOI:10.1007/s15006-021-0304-y Den ganzen Artikel lesen

J Dtsch Dermatol Ges. 2021 Oct;19(10):1463-1475. doi: 10.1111/ddg.14547. Epub 2021 Oct 7. ABSTRACT BACKGROUND AND OBJECTIVES: Documenting patient data in psoriasis clinical practice can improve care, but standardized and transparent documentation is rare. The current project aimed to develop a data set for the documentation of psoriasis in daily practice. MATERIAL AND METHODS: In four online Delphi rounds and one in-person meeting, 27 psoriasis experts allocated variables to a standard, an optim

Dermatol Ther (Heidelb). 2021 Oct 2. doi: 10.1007/s13555-021-00618-5. Online ahead of print. ABSTRACT INTRODUCTION: Obesity, smoking, and alcohol consumption are prevalent in psoriasis patients and have been associated with increased disease severity and reduced treatment adherence and response. This post hoc analysis of pooled data from the phase 3 AMAGINE-2 and -3 trials compared the efficacy of brodalumab versus ustekinumab in psoriasis patients with aggravating and potentiall

Ann Med. 2021 Dec;53(1):1727-1736. doi: 10.1080/07853890.2021.1986637. ABSTRACT OBJECTIVE: To critically analyse and define therapeutic objectives, response to treatment evaluation and related decisions in psoriasis. METHODS: Expert consensus meetings, a systematic and narrative reviews and a collaborative Delphi procedure were carried out. A steering committee from the Spanish Group of Psoriasis was established who based on the reviews generated a set of related statements. Subsequently, a grou

Atherosclerosis. 2021 Oct;335:98-109. doi: 10.1016/j.atherosclerosis.2021.09.024. Epub 2021 Sep 23. ABSTRACT Over the past fifteen years, treatments using monoclonal antibodies specifically targeting cytokines have been developed to treat chronic inflammatory diseases, including rheumatoid arthritis or psoriasis, both associated with increased cardiovascular risk. The cardiovascular impact of these therapies allows us to validate the clinical relevance of the knowledge acquired from experimental

Hautarzt. 2021 Nov;72(11):946-952. doi: 10.1007/s00105-021-04892-4. Epub 2021 Sep 30. ABSTRACT BACKGROUND: Psoriatic arthritis is the most important "comorbidity" of psoriasis, which impacts the work of dermatologists in many ways. OBJECTIVE: The relevance of joint involvement in psoriasis patients for the practicing dermatologist is considered. METHODS: An analysis of publications listed in PubMed® (Bethesda, MD, USA) on the topic of psoriatic arthritis in English, German, or French was carried

Clin Cosmet Investig Dermatol. 2021 Sep 21;14:1319-1330. doi: 10.2147/CCID.S332247. eCollection 2021. ABSTRACT Botulinum toxin (BoNT) is a neurotoxin produced by the Clostridium botulinum bacterium with a well-known efficacy and safety profile in the focal idiopathic hyperhidrosis treatment. BoNT comprises seven different neurotoxins; however, only toxins A and B are clinically employed. BoNT is lately practiced in off-label therapies for a variety of skin diseases. Scar prevention, hyperhidrosi

Nutrients. 2021 Aug 29;13(9):3015. doi: 10.3390/nu13093015. ABSTRACT Inflammatory diseases including psoriasis are associated with metabolic and cardiovascular comorbidities, including obesity and metabolic syndrome. Obesity is associated with greater psoriasis disease severity and reduced response to treatment. Therefore, targeting metabolic comorbidities could improve patients' health status and psoriasis-specific outcomes. METABOLyx is a randomized controlled trial evaluating the combination

J Invest Dermatol. 2021 Sep 23:S0022-202X(21)01409-3. doi: 10.1016/j.jid.2021.06.006. Online ahead of print. ABSTRACT Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflam

Dermatol Ther (Heidelb). 2021 Sep 24. doi: 10.1007/s13555-021-00606-9. Online ahead of print. ABSTRACT INTRODUCTION: There is limited and conflicting evidence over the real-world drug survival of secukinumab (SEC) in patients with psoriasis, especially in the long term. Our objective was to analyze the short- and long-term survival of SEC (S-SEC) and its predictive factors for the treatment of psoriasis. METHODS: Patients clinically diagnosed with plaque psoriasis and under treatment with secuk

Hautarzt. 2021 Sep 20. doi: 10.1007/s00105-021-04885-3. Online ahead of print. ABSTRACT BACKGROUND: With AtopicHealth1, the first national care study on atopic dermatitis (AD) was conducted in 2010. At that time, about one third of the patients undergoing treatment by dermatologists showed severe limitations in quality of life, which indicated an insufficient quality of care. The aim of the present study was to characterise the current care of patients with AD undergoing dermatological treatment

J Dermatol. 2021 Sep 12. doi: 10.1111/1346-8138.16128. Online ahead of print. ABSTRACT Psoriasis is a common, chronic inflammatory skin disorder negatively impacting health-related quality of life (HRQoL). Guselkumab, targeting interleukin-23 (IL-23), is an approved biologic therapy for psoriasis. PERSIST is an ongoing prospective, noninterventional, long-term, German multicenter study evaluating the effect of guselkumab on HRQoL, and its efficacy and safety in patients with moderate-to-severe p

Int J Cardiol. 2021 Sep 1:S0167-5273(21)01308-5. doi: 10.1016/j.ijcard.2021.08.042. Online ahead of print. ABSTRACT BACKGROUND: An increased risk for venous thromboembolism (VTE), comprising pulmonary embolism (PE) and deep venous thrombosis, has been reported in psoriasis patients. The impact of psoriasis on prognosis of VTE patients is widely unknown. METHODS: Hospitalized PE patients were stratified for psoriasis and the impact of psoriasis on outcome was investigated in the German nationwide

Eur J Dermatol. 2021 Aug 26. doi: 10.1684/ejd.2021.4087. Online ahead of print. NO ABSTRACT PMID:34463279 | DOI:10.1684/ejd.2021.4087 Den ganzen Artikel lesen

Ther Adv Neurol Disord. 2021 Aug 23;14:17562864211035542. doi: 10.1177/17562864211035542. eCollection 2021. ABSTRACT The past decades have yielded major therapeutic advances in many autoimmune conditions - such as multiple sclerosis (MS) - and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients

Postgrad Med. 2021 Sep 6:1-4. doi: 10.1080/00325481.2021.1974689. Online ahead of print. ABSTRACT Alopecia Areata is an inflammatory and T cell-mediated autoimmune reaction against unknown autoantigen of hair follicles characterized by patchy, non-scarring loss of hair follicles in the anagen phase. Although its etiology is minimally understood, genetic susceptibility, autoimmunity and stress are thought to be causative factors. It occurs in episodic and recurrent patterns with an incidence rate

Vaccines (Basel). 2021 Aug 1;9(8):843. doi: 10.3390/vaccines9080843. ABSTRACT The risk of developing severe complications from an influenza virus infection is increased in patients with chronic inflammatory diseases such as psoriasis (PsO) and atopic dermatitis (AD). However, low influenza vaccination rates have been reported. The aim of this study was to determine vaccination rates in PsO compared to AD patients and explore patient perceptions of vaccination. A multicenter cross-sectional study

Exp Dermatol. 2021 Aug 25. doi: 10.1111/exd.14452. Online ahead of print. ABSTRACT Psoriasis is one of the most common chronic inflammatory skin diseases and at the same time a risk factor for cardiovascular disease. Interleukin-17A (IL-17A)-mediated inflammation in psoriasis may lead to vascular dysfunction. This study aimed at investigating whether anti-inflammatory treatment by tumor necrosis factor (TNF)-α blockade alters vascular function in psoriasis patients. A total of 11 patients with p