Ausgewählte Studien

Rheumatol Ther. 2021 Aug 24. doi: 10.1007/s40744-021-00347-3. Online ahead of print. ABSTRACT BACKGROUND: Uncontrolled inflammatory disease activity can impact pregnancy outcomes and the health of the mother and child. This retrospective claims database analysis assessed treatment patterns before, during, and after pregnancy among women with inflammatory rheumatic disease (IRD; axial spondyloarthritis [axSpA], psoriatic arthritis [PsA], and rheumatoid arthritis [RA]) or psoriasis (PSO) in German

Hautarzt. 2021 Aug 20:1-8. doi: 10.1007/s00105-021-04871-9. Online ahead of print. ABSTRACT BACKGROUND: Moderate to severe plaque psoriasis can be treated effectively with immunomodulating biologicals such as the interleukin-17A inhibitor secukinumab. In practice, however, questions often arise as to how to proceed in special situations, such as infections, comorbidity, pregnancy, or surgery. OBJECTIVES: To address frequent questions about the treatment of plaque psoriasis with secukinumab in a

J Dtsch Dermatol Ges. 2021 Aug;19(8):1170-1177. doi: 10.1111/ddg.14451_g. NO ABSTRACT PMID:34390146 | DOI:10.1111/ddg.14451_g Den ganzen Artikel lesen

J Invest Dermatol. 2021 Jul 5:S0022-202X(21)01423-8. doi: 10.1016/j.jid.2021.06.013. Online ahead of print. ABSTRACT Sodium can accumulate in the skin, at concentrations exceeding serum levels. High sodium environment can lead to pathogenic T helper (Th)17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which interleukin (IL)-17-producing Th17 cells play a crucial role. In an observational study, we measured skin sodium content in psoriasis patients and age-matched healthy co

Hautarzt. 2021 Jul 6. doi: 10.1007/s00105-021-04853-x. Online ahead of print. ABSTRACT Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis. In addition to a sporadic form, a familial form is reported in around 40% of patients, for whom an autosomal dominant (AD) inheritance with reduced gene penetrance is assumed. The phenotype of the disease with inflammatory nodules, abscesses and secreting sinus tracts suggests an infectious origin, but the exact role of the bacteria

Int J Womens Dermatol. 2020 Oct 10;7(3):314-318. doi: 10.1016/j.ijwd.2020.09.012. eCollection 2021 Jun. ABSTRACT BACKGROUND: Each year, 20,000 patients aged <10 years are diagnosed with psoriasis. Pediatric-onset psoriasis has many similarities to adult-onset disease, and previous studies suggest that the incidence might be increasing in both populations. OBJECTIVE: The challenges that arise when treating patients with psoriasis, especially those age <12 years, are

Life (Basel). 2021 Jun 29;11(7):627. doi: 10.3390/life11070627. ABSTRACT The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs was evaluated to create a ranking algorithm. The combined use of PASI, BSA, and sPGA may allow the classification of the severit

Int J Mol Sci. 2021 Jun 23;22(13):6740. doi: 10.3390/ijms22136740. ABSTRACT The paradigm of psoriasis as a Th17-driven disease has evolved in the last years towards a much deeper knowledge of the complex pathways, mechanisms, cells, and messengers involved, highlighting the crucial role played by the IL-17 family of cytokines. All IL-17 isoforms signal through IL-17R. Five subunits of IL-17R have been described to date, which couple to form a homo- or hetero-receptor complex. Characteristically,

Biol Chem. 2021 Jun 30. doi: 10.1515/hsz-2021-0250. Online ahead of print. ABSTRACT Psoriasis is a frequent autoimmune-related skin disease, which involves various cell types such as T cells, keratinocytes and dendritic cells. Genetic variations, such as mutations of CARD14, can promote the development of the disease. CARD14 mutations as well as the stimulation of immune and cytokine receptors activate the paracaspase MALT1, a potent activator of the transcription factors NF-κB and AP-1. The dis

J Dtsch Dermatol Ges. 2021 Jun;19(6):934-150. doi: 10.1111/ddg.14508. NO ABSTRACT PMID:34139083 | DOI:10.1111/ddg.14508 Den ganzen Artikel lesen

J Dtsch Dermatol Ges. 2021 Jun;19(6):934-951. doi: 10.1111/ddg.14508_g. NO ABSTRACT PMID:34139080 | DOI:10.1111/ddg.14508_g Den ganzen Artikel lesen

Hautarzt. 2021 Jul;72(7):570-577. doi: 10.1007/s00105-021-04832-2. Epub 2021 Jun 16. ABSTRACT BACKGROUND: The skin is an organ frequently affected by chronic diseases. Inflammatory, immune-mediated dermatoses such as atopic dermatitis and psoriasis show a high prevalence as well as a significant impact on the quality of life of those affected. In a large proportion of cases, atopic dermatitis is associated with a marked change in microbial colonization of both clinically healthy and affected ski

Hautarzt. 2021 Jun 16. doi: 10.1007/s00105-021-04833-1. Online ahead of print. ABSTRACT BACKGROUND: Guidelines generally recommend an adjuvant treatment with emollients for patients suffering from psoriasis. However evidence for this purpose is limited. PATIENTS AND METHODS: We performed a prospective observational study with an emollient containing 10% urea, ceramides, glycerin and glyceryl glucoside in patients suffering from mild to moderate psoriasis. The patients had to be stable for at lea

Hautarzt. 2021 Jul;72(7):579-585. doi: 10.1007/s00105-021-04830-4. Epub 2021 Jun 11. ABSTRACT BACKGROUND: Our skin is a very important and complex organ of the body. The microorganisms of the skin, the so-called microbiome, represent an important part of the healthy skin barrier and are influenced by various external and internal factors. AIM: The question to what extent the skin microbiome represents a diagnostic or even therapeutic target in the context of skin diseases is discussed. MATERIALS

Clin Epidemiol. 2021 May 26;13:373-382. doi: 10.2147/CLEP.S304155. eCollection 2021. ABSTRACT BACKGROUND: Most epidemiological data on vitiligo refer to selected environments or focus on the prevalence of comorbidity unrelated to the population. OBJECTIVE: Aim of the study was to gain robust representative prevalence data on vitiligo and on associated dermatologic comorbidity in the German adult population. METHODS: A dual population-based approach was applied with 1) primary data obtained betwe

Br J Dermatol. 2021 Jun 2. doi: 10.1111/bjd.20527. Online ahead of print. ABSTRACT Eczema and eczematous reactions induced by interleukin (IL)-17 inhibitors in patients with psoriasis are established adverse events (1), which may be reported as adverse events (AEs) in up to 12.1% patients on anti-IL-17 treatment in controlled clinical trials (2-5). We performed an integrated safety analysis of 13 clinical studies to evaluate the frequency and management of the treatment-emergent adverse events (

Nutrients. 2021 May 31;13(6):1897. doi: 10.3390/nu13061897. ABSTRACT BACKGROUND: Psoriasis is a systemic inflammatory disorder, primarily characterized by skin plaques. It is linked to co-morbidities including cardiovascular disease and metabolic syndrome. Several studies demonstrate that dietary habits can influence psoriasis development and severity. However, the effect of different dietary protein levels on psoriasis development and severity is poorly understood. In this study, we examine the

J Eur Acad Dermatol Venereol. 2021 May 31. doi: 10.1111/jdv.17427. Online ahead of print. ABSTRACT In the context of the current coronavirus disease 2019 (COVID-19) pandemic, there is no direct evidence to support any preferred biologic therapy for psoriasis. However, known safety profile of different classes of biologic therapies as well as individual risk factors for infections must be considered. Here, we report incidence rates of respiratory or viral infections through 5 years among patients

Actas Dermosifiliogr. 2020 Nov;111(9):802-804. doi: 10.1016/j.adengl.2020.05.001. Epub 2020 Oct 16. NO ABSTRACT PMID:34012158 | PMC:PMC7566662 | DOI:10.1016/j.adengl.2020.05.001 Den ganzen Artikel lesen